Annual Reviews
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Chaperonin-Mediated Protein Folding
Annual Reviews - Tập 30 Số 1 - Trang 245-269 - 2001
▪ Abstract Molecular chaperones are required to assist folding of a subset of
proteins in Escherichia coli. We describe a conceptual framework for
understanding how the GroEL-GroES system assists misfolded proteins to reach
their native states. The architecture of GroEL consists of double toroids
stacked back-to-back. However, most of the fundamentals of the GroEL action can
be described in terms...
Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences
Annual Reviews - Tập 22 Số 1 - Trang 27-65 - 1993
The State of Lipid Rafts: From Model Membranes to Cells
Annual Reviews - Tập 32 Số 1 - Trang 257-283 - 2003
▪ Abstract Lipid raft microdomains were conceived as part of a mechanism for
the intracellular trafficking of lipids and lipid-anchored proteins. The raft
hypothesis is based on the behavior of defined lipid mixtures in liposomes and
other model membranes. Experiments in these well-characterized systems led to
operational definitions for lipid rafts in cell membranes. These definitions,
detergent...
Conformational Dynamics of the Chromatin Fiber in Solution: Determinants, Mechanisms, and Functions
Annual Reviews - Tập 31 Số 1 - Trang 361-392 - 2002
SINGLE-PARTICLE TRACKING:Applications to Membrane Dynamics
Annual Reviews - Tập 26 Số 1 - Trang 373-399 - 1997
▪ Abstract Measurements of trajectories of individual proteins or lipids in the
plasma membrane of cells show a variety of types of motion. Brownian motion is
observed, but many of the particles undergo non-Brownian motion, including
directed motion, confined motion, and anomalous diffusion. The variety of motion
leads to significant effects on the kinetics of reactions among membrane-bound
speci...
EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS
Annual Reviews - Tập 35 Số 1 - Trang 93-114 - 2006
Complex cellular events commonly depend on the activity of molecular “machines”
that efficiently couple enzymatic and regulatory functions within a multiprotein
assembly. An essential and expanding subset of these assemblies comprises
proteins of the ATPases associated with diverse cellular activities (AAA+)
family. The defining feature of AAA+ proteins is a structurally conserved
ATP-binding modu...
ELECTRON TOMOGRAPHY OF MEMBRANE-BOUND CELLULAR ORGANELLES
Annual Reviews - Tập 35 Số 1 - Trang 199-224 - 2006
Electron microscope tomography produces three-dimensional reconstructions and
has been used to image organelles both isolated and in situ, providing new
insight into their structure and function. It is analogous to the various
tomographies used in medical imaging. Compared with light microscopy, electron
tomography offers an improvement in resolution of 30- to 80-fold and currently
ranges from 3 t...
THE PROTEASOME
Annual Reviews - Tập 28 Số 1 - Trang 295-317 - 1999
▪ Abstract Proteasomes are large multisubunit proteases that are found in the
cytosol, both free and attached to the endoplasmic reticulum, and in the nucleus
of eukaryotic cells. Their ubiquitous presence and high abundance in these
compartments reflects their central role in cellular protein turnover.
Proteasomes recognize, unfold, and digest protein substrates that have been
marked for degrada...
Gating-Spring Models of Mechanoelectrical Transduction by Hair Cells of the Internal Ear
Annual Reviews - Tập 24 Số 1 - Trang 59-83 - 1995
HIERARCHY AND DYNAMICS OF RNA FOLDING
Annual Reviews - Tập 26 Số 1 - Trang 113-137 - 1997
▪ Abstract The evidence showing that the self-assembly of complex RNAs occurs
in discrete transitions, each relating to the folding of sub-systems of
increasing size and complexity starting from a state with most of the secondary
structure, is reviewed. The reciprocal influence of the concentration of
magnesium ions and nucleotide mutations on tertiary structure is analyzed.
Several observations ...
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