Annual Reviews
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Chaperonin-Mediated Protein Folding ▪ Abstract Molecular chaperones are required to assist folding of a subset of proteins in Escherichia coli. We describe a conceptual framework for understanding how the GroEL-GroES system assists misfolded proteins to reach their native states. The architecture of GroEL consists of double toroids stacked back-to-back. However, most of the fundamentals of the GroEL action can be described... ...
Annual Reviews - Tập 30 Số 1 - Trang 245-269 - 2001
The State of Lipid Rafts: From Model Membranes to Cells▪ Abstract Lipid raft microdomains were conceived as part of a mechanism for the intracellular trafficking of lipids and lipid-anchored proteins. The raft hypothesis is based on the behavior of defined lipid mixtures in liposomes and other model membranes. Experiments in these well-characterized systems led to operational definitions for lipid rafts in cell membranes. These definitions, d... ...
Annual Reviews - Tập 32 Số 1 - Trang 257-283 - 2003
Bilayer Thickness and Membrane Protein Function: An Energetic Perspective The lipid bilayer component of biological membranes is important for the distribution, organization, and function of bilayer-spanning proteins. This regulation is due to both specific lipid-protein interactions and general bilayer-protein interactions, which modulate the energetics and kinetics of protein conformational transitions, as well as the protein distribution between different me... ...
Annual Reviews - Tập 36 Số 1 - Trang 107-130 - 2007
Solubilization and Functional Reconstitution of Biomembrane Components
Annual Reviews - Tập 21 Số 1 - Trang 323-348 - 1992
Macromolecular Crowding: Biochemical, Biophysical, and Physiological Consequences
Annual Reviews - Tập 22 Số 1 - Trang 27-65 - 1993
Conformational Dynamics of the Chromatin Fiber in Solution: Determinants, Mechanisms, and Functions
Annual Reviews - Tập 31 Số 1 - Trang 361-392 - 2002
SINGLE-PARTICLE TRACKING:Applications to Membrane Dynamics▪ Abstract Measurements of trajectories of individual proteins or lipids in the plasma membrane of cells show a variety of types of motion. Brownian motion is observed, but many of the particles undergo non-Brownian motion, including directed motion, confined motion, and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of reactions among membrane-bou... ...
Annual Reviews - Tập 26 Số 1 - Trang 373-399 - 1997
EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINSComplex cellular events commonly depend on the activity of molecular “machines” that efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An essential and expanding subset of these assemblies comprises proteins of the ATPases associated with diverse cellular activities (AAA+) family. The defining feature of AAA+ proteins is a structurally conserved ATP-bind... ...
Annual Reviews - Tập 35 Số 1 - Trang 93-114 - 2006
ELECTRON TOMOGRAPHY OF MEMBRANE-BOUND CELLULAR ORGANELLES Electron microscope tomography produces three-dimensional reconstructions and has been used to image organelles both isolated and in situ, providing new insight into their structure and function. It is analogous to the various tomographies used in medical imaging. Compared with light microscopy, electron tomography offers an improvement in resolution of 30- to 80-fold and currently ranges... ...
Annual Reviews - Tập 35 Số 1 - Trang 199-224 - 2006
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