Bilayer Thickness and Membrane Protein Function: An Energetic Perspective

Annual Reviews - Tập 36 Số 1 - Trang 107-130 - 2007
Olaf S. Andersen1, Roger E. Koeppe2
1Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA
2Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, 72701

Tóm tắt

The lipid bilayer component of biological membranes is important for the distribution, organization, and function of bilayer-spanning proteins. This regulation is due to both specific lipid-protein interactions and general bilayer-protein interactions, which modulate the energetics and kinetics of protein conformational transitions, as well as the protein distribution between different membrane compartments. The bilayer regulation of membrane protein function arises from the hydrophobic coupling between the protein's hydrophobic domains and the bilayer hydrophobic core, which causes protein conformational changes that involve the protein/bilayer boundary to perturb the adjacent bilayer. Such bilayer perturbations, or deformations, incur an energetic cost, which for a given conformational change varies as a function of the bilayer material properties (bilayer thickness, intrinsic lipid curvature, and the elastic compression and bending moduli). Protein function therefore is regulated by changes in bilayer material properties, which determine the free-energy changes caused by the protein-induced bilayer deformation. The lipid bilayer thus becomes an allosteric regulator of membrane function.

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Annual Reviews

Tập 36 Số 1

107-130

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