Annals of Neurology
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Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy
Annals of Neurology - Tập 57 Số 2 - Trang 188-196 - 2005
AbstractDiffusion tensor magnetic resonance imaging can acquire quantitative
information on the microstructural integrity of white matter structures and
depict brain connectivity in vivo based on the behavior of water diffusion.
Diffusion tensor imaging–derived tractography has been used for virtual
dissection of the fornix and cingulum in healthy subjects, but not in patients
with temporal lobe e...
Radation therapy for brain metastases
Annals of Neurology - Tập 7 Số 6 - Trang 529-541 - 1980
AbstractWe treated 183 patients who had brain metastases with whole‐brain
radiation therapy (RT) and adrenocortico‐ steroids utilizing a new high‐dose
radiation protocol. Treatment produced neurological improvement in 135 patients
(74%); there was no change in 37 (20%), and deterioration occurred i n l l (6%).
Of those patients who improved, two‐thirds maintained neurological improvement
for the r...
Probabilistic Mapping of Deep Brain Stimulation: Insights from 15 Years of Therapy
Annals of Neurology - Tập 89 Số 3 - Trang 426-443 - 2021
Deep brain stimulation (DBS) depends on precise delivery of electrical current
to target tissues. However, the specific brain structures responsible for best
outcome are still debated. We applied probabilistic stimulation mapping to a
retrospective, multidisorder DBS dataset assembled over 15 years at our
institution (ntotal = 482 patients; nParkinson disease = 303; ndystonia = 64;
ntremor = 39; n...
X‐linked neuropathy: Gene localization with DNA probes
Annals of Neurology - Tập 20 Số 4 - Trang 527-532 - 1986
AbstractWe used probes for DNA polymorphisms on the X chromosome to study
genetic linkage in four families with X‐linked neuropathy. Despite clinical
variability, all four families showed the same linkage pattern. We found
evidence in each family of linkage to the marker DXYS1 on the proximal long arm
of the X chromosome, as reported by others. We also found linkage to p58—1
(DXS14) on the proxima...
Genetic linkage evidence for heterogeneity in Charcot‐Marie‐Tooth neuropathy (HMSN type I)
Annals of Neurology - Tập 14 Số 6 - Trang 679-684 - 1983
AbstractA genetic linkage study performed on a large family with autosomal
dominant Charcot‐Marie‐Tooth neuropathy (HMSN type I) showed affected family
members to have slow motor nerve conduction velocities, hypoactive tendon
reflexes, and distal muscle weakness and atrophy. Results excluded close linkage
of the neuropathy in this family to the Duffy blood group locus on chromosome 1.
Previous stu...
Peripheral nerve conduction in fabry disease
Annals of Neurology - Tập 7 Số 4 - Trang 319-323 - 1980
AbstractPeripheral nerve conduction was studied in 34 members, aged 3 to 54
years, from three separate kindreds with Fabry disease. Nerve conduction
velocity was prolonged in one‐third (11 of 34) of the study group. Of the 9
control family members with normal plasma α‐galactosidase levels, 8 had normal
velocity. A 6‐year‐old girl with normal plasma and leukocyte α‐galactosidase
levels and absent c...
Axonal transport in neurological disease
Annals of Neurology - Tập 23 Số 1 - Trang 3-13 - 1988
AbstractThe axonal transport systems have a wide variety of primary roles and
secondary responses in neurological disease processes. Recent advances in
understanding these roles have built on the increasingly detailed insights into
the cell biology of the axon and its supporting cells. Fast transport is a
microtubule‐based system of bidirectional movement of membranous organelles; the
mechanism of...
Intensive evaluation of referred unclassified neuropathies yields improved diagnosis
Annals of Neurology - Tập 10 Số 3 - Trang 222-226 - 1981
AbstractIntensive evaluation of 205 cases of undiagnosed neuropathy in a center
with special approaches and facilities permittede classification of 76% of the
patients. Inherited disorders accounted for 42% of the series, 21% of the
patients were shown to have inflammatory‐demyelinating polyradiculoneuropathy,
and 13% had neuropathies assocciated with other disorders. A considerable
improvement in...
Homocysteine exacerbates β‐amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles
Annals of Neurology - Tập 75 Số 6 - Trang 851-863 - 2014
ObjectiveHigh level of homocysteine (Hcy) is a recognized risk factor for
developing Alzheimer disease (AD). However, the mechanisms involved are unknown.
Previously, it was shown that high Hcy increases brain β‐amyloid (Aβ) levels in
amyloid precursor protein transgenic mice, but no data are available on the
effect that it may have on the other main pathologic features of AD such as
tau.Methods3x...
The mutation at nt 8993 of mitochondrial DNA is a common cause of Leigh's syndrome
Annals of Neurology - Tập 34 Số 6 - Trang 827-834 - 1993
AbstractTwelve patients with Leigh's syndrome from 10 families harbored a T > G
point mutation at nt 8993 of mtDNA. This mutation, initially associated with
neurogenic weakness, ataxia, and retinitis pigmentosa, was later found to result
in the Leigh phenotype when present in a high percentage. In our patients, the
mutation was heteroplasmic, maternally inherited, and appeared to segregate
rapidly...
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