Annals of Neurology
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Fixation‐off—sensitive epilepsy in eyelid myoclonia with absence seizuresAbstract Fixation‐off—sensitive epilepsy is documented in a patient with eyelid myoclonia with absences. A series of simple electroencephalographic techniques showed that elimination of visual fixation is the actual stimulus for the eyelid myoclonus.
Annals of Neurology - Tập 22 Số 1 - Trang 87-89 - 1987
Neonatal intensive care unit stress is associated with brain development in preterm infantsAbstract Objective: Although many perinatal factors have been linked to adverse neurodevelopmental outcomes in very premature infants, much of the variation in outcome remains unexplained. The impact on brain development of 1 potential factor, exposure to stressors in the neonatal intensive care unit, has not yet been studied in a s...
Annals of Neurology - Tập 70 Số 4 - Trang 541-549 - 2011
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosisAbstract Until recently, all approved multiple sclerosis (MS) disease treatments were administered parenterally. Oral fingolimod was approved in September 2010 by the US Food and Drug Administration to reduce relapses and disability progression in relapsing forms of MS. In the clinical trials that led to approval, fingolimod reduced not only acute relapses and magne... ... hiện toàn bộ
Annals of Neurology - Tập 69 Số 5 - Trang 759-777 - 2011
1,026 Experimental treatments in acute strokeAbstract Objective Preclinical evaluation of neuroprotectants fostered high expectations of clinical efficacy. When not matched, the question arises whether experiments are poor indicators of clinical outcome or whether the best drugs were not taken forward to cli...
Annals of Neurology - Tập 59 Số 3 - Trang 467-477 - 2006
Histopathological correlates of magnetic resonance imaging–defined chronic perinatal white matter injuryAbstract Objective: Although magnetic resonance imaging (MRI) is the optimal imaging modality to define cerebral white‐matter injury (WMI) in preterm survivors, the histopathological features of MRI‐defined chronic lesions are poorly defined. We hypothesized that chronic WMI is related to a combination of delayed oligodendrocyte (OL...
Annals of Neurology - Tập 70 Số 3 - Trang 493-507 - 2011
Validation of a new coma scale: The FOUR scoreAbstract The Glasgow Coma Scale (GCS) has been widely adopted. Failure to assess the verbal score in intubated patients and the inability to test brainstem reflexes are shortcomings. We devised a new coma score, the FOUR (Full Outline of UnResponsiveness) score. It consists of four components (eye, motor, brainstem, and respiration), and each component has a maximal... ... hiện toàn bộ
Annals of Neurology - Tập 58 Số 4 - Trang 585-593 - 2005
Progressive dystonia with marked diurnal fluctuationAbstract Three children, 2 of them siblings, developed a progressive dystonic condition in the first decade of life. The symptoms and signs were milder in the mornings or after a daytime nap but worsened greatly later in the day. One patient became unable to walk by evening. Investigations in 2 patients revealed a reduced concentration of cerebrospinal fluid homovan... ... hiện toàn bộ
Annals of Neurology - Tập 4 Số 5 - Trang 412-417 - 1978
Age differences in intercorrelations between regional cerebral metabolic rates for glucoseAbstract Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole‐brain glucose metabolism, partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by posit... ... hiện toàn bộ
Annals of Neurology - Tập 19 Số 1 - Trang 60-67 - 1986
A TREM 1 variant alters the accumulation of Alzheimer‐related amyloid pathologyObjective Genome‐wide association studies have linked variants in TREM2 (triggering receptor expressed on myeloid cells 2) and TREML2 with Alzheimer disease (AD) and AD endophenotypes. Here, we pursue a targeted analysis of the TREM locus in relation to cognitive decline and p...
Annals of Neurology - Tập 77 Số 3 - Trang 469-477 - 2015
Genetic linkage evidence for heterogeneity in Charcot‐Marie‐Tooth neuropathy (HMSN type I)Abstract A genetic linkage study performed on a large family with autosomal dominant Charcot‐Marie‐Tooth neuropathy (HMSN type I) showed affected family members to have slow motor nerve conduction velocities, hypoactive tendon reflexes, and distal muscle weakness and atrophy. Results excluded close linkage of the neuropathy in this family to the Duffy blood group lo... ... hiện toàn bộ
Annals of Neurology - Tập 14 Số 6 - Trang 679-684 - 1983
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