Annals of Neurology
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Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsyAbstract Diffusion tensor magnetic resonance imaging can acquire quantitative information on the microstructural integrity of white matter structures and depict brain connectivity in vivo based on the behavior of water diffusion. Diffusion tensor imaging–derived tractography has been used for virtual dissection of the fornix and cingulum in healthy subjects, but not... ...
Annals of Neurology - Tập 57 Số 2 - Trang 188-196 - 2005
Radation therapy for brain metastasesAbstract We treated 183 patients who had brain metastases with whole‐brain radiation therapy (RT) and adrenocortico‐ steroids utilizing a new high‐dose radiation protocol. Treatment produced neurological improvement in 135 patients (74%); there was no change in 37 (20%), and deterioration occurred i n l l (6%). Of those patients who improved, two‐thirds maintained n... ...
Annals of Neurology - Tập 7 Số 6 - Trang 529-541 - 1980
Immunological and pathological study of anti‐Ri–associated encephalopathyAbstract A patient with high titers of the anti‐Ri antibody died 3 years after a progressive course with ataxia, opsoclonus, dementia, and peripheral neuropathy. At autopsy, no tumor was found. The nervous system exhibited severe Purkinje cell loss and contained perivascular and interstitial inflammatory infiltrates, particularly involving the brainstem. B and CD4 c... ...
Annals of Neurology - Tập 36 Số 6 - Trang 896-902 - 1994
Primary progressive aphasiaAbstract Primary progressive aphasia (PPA) is a focal dementia characterized by an isolated and gradual dissolution of language function. The disease starts with word‐finding disturbances (anomia) and frequently proceeds to impair the grammatical structure (syntax) and comprehension (semantics) of language. The speech output in PPA can be fluent or nonfluent. Memory... ...
Annals of Neurology - Tập 49 Số 4 - Trang 425-432 - 2001
Leptomeningeal tumor in primarchy central nervous system lymphoma: Recognition, significance, and implicationsAbstract The true incidence of leptomeningeal tumor in priMarchy central nervous system lymphoma is unknown. We studied prospectively the cerebrospinal fluid profile of 96 patients without acquired immunodeficiency syndrome but with priMarchy central nervous system lymphoma at diagnosis, at completion of treatment, and at recurrence. Magnetic resonance images and pa... ...
Annals of Neurology - Tập 38 Số 2 - Trang 202-209 - 1995
Central nervous system excitatory effects of meperidine in cancer patientsAbstract The analgesic meperidine has been reported to produce signs of central nervous system excitation in human beings. To determine the relationship between signs and symptoms of central nervous system excitation and plasma levels of meperidine and normeperidine, we studied 67 patients receiving meperidine for the relief of postoperative or chronic pain. In 48 p... ...
Annals of Neurology - Tập 13 Số 2 - Trang 180-185 - 1983
Ischemic stroke is associated with the ABO locus: The EuroCLOT studyAbstract Objective : End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype....
Annals of Neurology - Tập 73 Số 1 - Trang 16-31 - 2013
Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memoryAbstract Objective: The goal of this study was to investigate the role of endogenous amyloid‐β peptide (Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a type of synaptic plasticity that is thought to be associated with learning and memory, was examined throug...
Annals of Neurology - Tập 69 Số 5 - Trang 819-830 - 2011
Acute neurological dysfunction associated with destructive lesions of the basal ganglia in childrenAbstract Three children ranging in age from 1 to 41/4 years suffered an acute illness with disturbance of consciousness followed by motor rigidity, loss of spontaneous movements and language, axial hypotonia, and a stereotyped response to any kind of stimulus. In two cases, images on computerized tomography were consistent with necrosis of the lenticular and caudate... ...
Annals of Neurology - Tập 12 Số 4 - Trang 328-332 - 1982
Gaze distractibility in wilson's diseaseAbstract We describe the case of a patient with Wilson's disease who was first seen with distractibility of gaze fixation. Clinical and magnetic resonance imaging studies suggest that the disorder was probably due to frontal lobe involvement.
Annals of Neurology - Tập 25 Số 4 - Trang 415-417 - 1989
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