Annals of Neurology
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Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsyAbstract Diffusion tensor magnetic resonance imaging can acquire quantitative information on the microstructural integrity of white matter structures and depict brain connectivity in vivo based on the behavior of water diffusion. Diffusion tensor imaging–derived tractography has been used for virtual dissection of the fornix and cingulum in healthy subjects, but not... ...
Annals of Neurology - Tập 57 Số 2 - Trang 188-196 - 2005
Radation therapy for brain metastasesAbstract We treated 183 patients who had brain metastases with whole‐brain radiation therapy (RT) and adrenocortico‐ steroids utilizing a new high‐dose radiation protocol. Treatment produced neurological improvement in 135 patients (74%); there was no change in 37 (20%), and deterioration occurred i n l l (6%). Of those patients who improved, two‐thirds maintained n... ...
Annals of Neurology - Tập 7 Số 6 - Trang 529-541 - 1980
Probabilistic Mapping of Deep Brain Stimulation: Insights from 15 Years of TherapyDeep brain stimulation (DBS) depends on precise delivery of electrical current to target tissues. However, the specific brain structures responsible for best outcome are still debated. We applied probabilistic stimulation mapping to a retrospective, multidisorder DBS dataset assembled over 15 years at our institution (ntotal = 482 patients; nParkinson disease... ...
Annals of Neurology - Tập 89 Số 3 - Trang 426-443 - 2021
Genetic linkage evidence for heterogeneity in Charcot‐Marie‐Tooth neuropathy (HMSN type I)Abstract A genetic linkage study performed on a large family with autosomal dominant Charcot‐Marie‐Tooth neuropathy (HMSN type I) showed affected family members to have slow motor nerve conduction velocities, hypoactive tendon reflexes, and distal muscle weakness and atrophy. Results excluded close linkage of the neuropathy in this family to the Duffy blood group lo... ...
Annals of Neurology - Tập 14 Số 6 - Trang 679-684 - 1983
X‐linked neuropathy: Gene localization with DNA probesAbstract We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in four families with X‐linked neuropathy. Despite clinical variability, all four families showed the same linkage pattern. We found evidence in each family of linkage to the marker DXYS1 on the proximal long arm of the X chromosome, as reported by others. We also found linkag... ...
Annals of Neurology - Tập 20 Số 4 - Trang 527-532 - 1986
Peripheral nerve conduction in fabry diseaseAbstract Peripheral nerve conduction was studied in 34 members, aged 3 to 54 years, from three separate kindreds with Fabry disease. Nerve conduction velocity was prolonged in one‐third (11 of 34) of the study group. Of the 9 control family members with normal plasma α‐galactosidase levels, 8 had normal velocity. A 6‐year‐old girl with normal plasma and leukocyte α‐... ...
Annals of Neurology - Tập 7 Số 4 - Trang 319-323 - 1980
Axonal transport in neurological diseaseAbstract The axonal transport systems have a wide variety of primary roles and secondary responses in neurological disease processes. Recent advances in understanding these roles have built on the increasingly detailed insights into the cell biology of the axon and its supporting cells. Fast transport is a microtubule‐based system of bidirectional movement of membra... ...
Annals of Neurology - Tập 23 Số 1 - Trang 3-13 - 1988
Intensive evaluation of referred unclassified neuropathies yields improved diagnosisAbstract Intensive evaluation of 205 cases of undiagnosed neuropathy in a center with special approaches and facilities permittede classification of 76% of the patients. Inherited disorders accounted for 42% of the series, 21% of the patients were shown to have inflammatory‐demyelinating polyradiculoneuropathy, and 13% had neuropathies assocciated with other disorde... ...
Annals of Neurology - Tập 10 Số 3 - Trang 222-226 - 1981
Homocysteine exacerbates β‐amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tanglesObjective High level of homocysteine (Hcy) is a recognized risk factor for developing Alzheimer disease (AD). However, the mechanisms involved are unknown. Previously, it was shown that high Hcy increases brain β‐amyloid (Aβ) levels in amyloid precursor protein transgenic mice, but no data are available on the effect that it may have on the other main path...
Annals of Neurology - Tập 75 Số 6 - Trang 851-863 - 2014
The mutation at nt 8993 of mitochondrial DNA is a common cause of Leigh's syndromeAbstract Twelve patients with Leigh's syndrome from 10 families harbored a T > G point mutation at nt 8993 of mtDNA. This mutation, initially associated with neurogenic weakness, ataxia, and retinitis pigmentosa, was later found to result in the Leigh phenotype when present in a high percentage. In our patients, the mutation was heteroplasmic, maternally inherite... ...
Annals of Neurology - Tập 34 Số 6 - Trang 827-834 - 1993
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