Annals of Neurology
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Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsyAbstract Diffusion tensor magnetic resonance imaging can acquire quantitative information on the microstructural integrity of white matter structures and depict brain connectivity in vivo based on the behavior of water diffusion. Diffusion tensor imaging–derived tractography has been used for virtual dissection of the fornix and cingulum in healthy subjects, but not... ...
Annals of Neurology - Tập 57 Số 2 - Trang 188-196 - 2005
Radation therapy for brain metastasesAbstract We treated 183 patients who had brain metastases with whole‐brain radiation therapy (RT) and adrenocortico‐ steroids utilizing a new high‐dose radiation protocol. Treatment produced neurological improvement in 135 patients (74%); there was no change in 37 (20%), and deterioration occurred i n l l (6%). Of those patients who improved, two‐thirds maintained n... ...
Annals of Neurology - Tập 7 Số 6 - Trang 529-541 - 1980
Probabilistic Mapping of Deep Brain Stimulation: Insights from 15 Years of TherapyDeep brain stimulation (DBS) depends on precise delivery of electrical current to target tissues. However, the specific brain structures responsible for best outcome are still debated. We applied probabilistic stimulation mapping to a retrospective, multidisorder DBS dataset assembled over 15 years at our institution (ntotal = 482 patients; nParkinson disease... ...
Annals of Neurology - Tập 89 Số 3 - Trang 426-443 - 2021
Axonal transport in neurological diseaseAbstract The axonal transport systems have a wide variety of primary roles and secondary responses in neurological disease processes. Recent advances in understanding these roles have built on the increasingly detailed insights into the cell biology of the axon and its supporting cells. Fast transport is a microtubule‐based system of bidirectional movement of membra... ...
Annals of Neurology - Tập 23 Số 1 - Trang 3-13 - 1988
Intensive evaluation of referred unclassified neuropathies yields improved diagnosisAbstract Intensive evaluation of 205 cases of undiagnosed neuropathy in a center with special approaches and facilities permittede classification of 76% of the patients. Inherited disorders accounted for 42% of the series, 21% of the patients were shown to have inflammatory‐demyelinating polyradiculoneuropathy, and 13% had neuropathies assocciated with other disorde... ...
Annals of Neurology - Tập 10 Số 3 - Trang 222-226 - 1981
Leigh syndrome: Clinical features and biochemical and DNA abnormalitiesAbstract We investigated the etiology of Leigh syndrome in 67 Australian cases from 56 pedigrees, 35 with a firm diagnosis and 32 with some atypical features. Biochemical or DNA defects were determined in both groups, ie, 80% in the tightly defined group and 41% in the “Leigh‐like” group. Eleven patients had mitochondrial DNA point mutations (nucleotide [nt] 8993 T ... ...
Annals of Neurology - Tập 39 Số 3 - Trang 343-351 - 1996
Magnetic resonance imaging pattern learning in temporal lobe epilepsy: Classification and prognosticsObjective In temporal lobe epilepsy (TLE), although hippocampal atrophy lateralizes the focus, the value of magnetic resonance imaging (MRI) to predict postsurgical outcome is rather modest. Prediction solely based on the hippocampus may be hampered by widespread mesiotemporal structural damage shown by advanced imaging. Increasingly complex and high‐dimen...
Annals of Neurology - Tập 77 Số 3 - Trang 436-446 - 2015
Mutation in BAG3 causes severe dominant childhood muscular dystrophyAbstract Objective Myofibrillar myopathies (MFMs) are morphologically distinct but genetically heterogeneous muscular dystrophies in which disintegration of Z disks and then of myofibrils is followed by ectopic accumulation of multiple proteins. Cardiomyopathy, neuropathy, and dominant inheritance are frequent associated features. M...
Annals of Neurology - Tập 65 Số 1 - Trang 83-89 - 2009
Likelihood of seizure remission in an adult population with refractory epilepsyAbstract Objective We aimed to determine the likelihood of remission and its clinical predictors in adult patients meeting a strict definition of refractory epilepsy. We also wanted to investigate the influence of treatment regimen on remission. Methods A total of 246 pati...
Annals of Neurology - Tập 62 Số 4 - Trang 382-389 - 2007
Immunological and pathological study of anti‐Ri–associated encephalopathyAbstract A patient with high titers of the anti‐Ri antibody died 3 years after a progressive course with ataxia, opsoclonus, dementia, and peripheral neuropathy. At autopsy, no tumor was found. The nervous system exhibited severe Purkinje cell loss and contained perivascular and interstitial inflammatory infiltrates, particularly involving the brainstem. B and CD4 c... ...
Annals of Neurology - Tập 36 Số 6 - Trang 896-902 - 1994
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