Changes in dynamic arterial elastance induced by volume expansion and vasopressor in the operating room: a prospective bicentre studyAnnals of Intensive Care - - 2019
Hugues de Courson, Philippe Boyer, Romain Grobost, Romain Lanchon, Musa Sesay, Karine Nouette-Gaulain, Emmanuel Futier, Matthieu Biais
Dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variations and stroke volume variations, has been proposed to assess functional arterial load. We evaluated the evolution of Eadyn during volume expansion and the effects of neosynephrine infusion in hypotensive and preload-responsive patients. In this prospective bicentre study, we included 56 mechanically ventilated ...... hiện toàn bộ
Understanding brain dysfunction in sepsisAnnals of Intensive Care - Tập 3 - Trang 1-11 - 2013
Romain Sonneville, Franck Verdonk, Camille Rauturier, Isabelle F Klein, Michel Wolff, Djillali Annane, Fabrice Chretien, Tarek Sharshar
Sepsis often is characterized by an acute brain dysfunction, which is associated with increased morbidity and mortality. Its pathophysiology is highly complex, resulting from both inflammatory and noninflammatory processes, which may induce significant alterations in vulnerable areas of the brain. Important mechanisms include excessive microglial activation, impaired cerebral perfusion, blood–brai...... hiện toàn bộ
Vasopressin and its analogues in shock states: a reviewAnnals of Intensive Care - Tập 10 - Trang 1-7 - 2020
Julien Demiselle, Nicolas Fage, Peter Radermacher, Pierre Asfar
Activation of arginine–vasopressin is one of the hormonal responses to face vasodilation-related hypotension. Released from the post-pituitary gland, vasopressin induces vasoconstriction through the activation of V1a receptors located on vascular smooth muscle cells. Due to its non-selective receptor affinity arginine–vasopressin also activates V2 (located on renal tubular cells of collecting duct...... hiện toàn bộ
Clinical outcomes of COVID-19 in Wuhan, China: a large cohort studyAnnals of Intensive Care - Tập 10 - Trang 1-21 - 2020
Jiao Liu, Sheng Zhang, Zhixiong Wu, You Shang, Xuan Dong, Guang Li, Lidi Zhang, Yizhu Chen, Xiaofei Ye, Hangxiang Du, Yongan Liu, Tao Wang, SiSi Huang, Limin Chen, Zhenliang Wen, Jieming Qu, Dechang Chen
Since December 2019, an outbreak of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) initially emerged in Wuhan, China, and has spread worldwide now. Clinical features of patients with COVID-19 have been described. However, risk factors leading to in-hospital deterioration and poor prognosis in COVID-19 patients with severe disease have...... hiện toàn bộ
Risk factors for severe COVID-19 in the young—before and after ICU admissionAnnals of Intensive Care - Tập 13 - Trang 1-12 - 2023
Johanna Kämpe, Olof Bohlin, Martin Jonsson, Robin Hofmann, Jacob Hollenberg, Rebecka Rubenson Wahlin, Per Svensson, Per Nordberg
Factors associated with severe COVID-19 and death among young adults are not fully understood, including differences between the sexes. The aim of this study was to identify factors associated with severe COVID-19 requiring intensive care and 90-day mortality among women and men below 50 years of age. A register-based study using data from mandatory national registers, where patients with severe C...... hiện toàn bộ
Treatment of critically ill patients with cefiderocol for infections caused by multidrug-resistant pathogens: review of the evidenceAnnals of Intensive Care - Tập 13 - Trang 1-25 - 2023
Pierluigi Viale, Christian E. Sandrock, Paula Ramirez, Gian Maria Rossolini, Thomas P. Lodise
Appropriate antibiotic treatment for critically ill patients with serious Gram-negative infections in the intensive care unit is crucial to minimize morbidity and mortality. Several new antibiotics have shown in vitro activity against carbapenem-resistant Enterobacterales (CRE) and difficult-to-treat resistant Pseudomonas aeruginosa. Cefiderocol is the first approved siderophore beta-lactam antibi...... hiện toàn bộ