Insights and limits of translational research in critical care medicine
Tóm tắt
Từ khóa
Tài liệu tham khảo
Wurfel MM, Gordon AC, Holden TD, Radella F, Strout J, Kajikawa O, et al.: Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med 2008, 178: 710–20. 10.1164/rccm.200803-462OC
Whitham S, Dinesh-Kumar SP, Choi D, Hehl R, Corr C, Baker B: The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. Cell 1994, 78: 1101–15. 10.1016/0092-8674(94)90283-6
Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996, 86: 973–83. 10.1016/S0092-8674(00)80172-5
Williams MJ, Rodriguez A, Kimbrell DA, Eldon ED: The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J 1997, 16: 6120–30. 10.1093/emboj/16.20.6120
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388: 394–7. 10.1038/41131
Iwasaki A, Medzhitov R: Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004, 5: 987–95. 10.1038/ni1112
Mifsud EJ, Tan AC, Jackson DC: TLR agonists as modulators of the innate immune response and their potential as agents against infectious disease. Front Immunol 2014, 5: 79. 10.3389/fimmu.2014.00079
Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA: A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000, 68: 6398–401. 10.1128/IAI.68.11.6398-6401.2000
Lorenz E, Mira JP, Frees KL, Schwartz DA: Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 2002, 162: 1028–32. 10.1001/archinte.162.9.1028
Toubiana J, Courtine E, Pene F, Viallon V, Asfar P, Daubin C, et al.: IRAK1 functional genetic variant affects severity of septic shock. Crit Care Med 2010, 38: 2287–94. 10.1097/CCM.0b013e3181f9f9c7
Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, et al.: Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 2003, 299: 2076–9. 10.1126/science.1081902
von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, et al.: Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008, 321: 691–6. 10.1126/science.1158298
Buras JA, Holzmann B, Sitkovsky M: Animal models of sepsis: setting the stage. Nat Rev Drug Discov 2005, 4: 854–65. 10.1038/nrd1854
Lorente JA, Marshall JC: Neutralization of tumor necrosis factor in preclinical models of sepsis. Shock 2005,24(Suppl 1):107–19. 10.1097/01.shk.0000191343.21228.78
Bernard GR, Francois B, Mira JP, Vincent JL, Dellinger RP, Russell JA, et al.: Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-alpha fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study. Crit Care Med 2014, 42: 504–11. 10.1097/CCM.0000000000000043
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al.: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013, 39: 165–228. 10.1007/s00134-012-2769-8
Lopez A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, et al.: Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004, 32: 21–30. 10.1097/01.CCM.0000105581.01815.C6
Fisher CJ Jr, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, et al.: Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996, 334: 1697–702. 10.1056/NEJM199606273342603
Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al.: Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 2013, 110: 3507–12. 10.1073/pnas.1222878110
Dreyfuss D, Soler P, Basset G, Saumon G: High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 1988, 137: 1159–64. 10.1164/ajrccm/137.5.1159
ARDSnetwork: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network N Engl J Med 2000, 342: 1301–8. 10.1056/NEJM200005043421801
Asfar P, Claessens YE, Duranteau J, Kipnis E, Leone M, Levy B, et al.: Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge? Ann Intensive Care 2013, 3: 27. 10.1186/2110-5820-3-27
Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, et al.: The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 2010, 36: 222–31. 10.1007/s00134-009-1738-3
Pavon A, Binquet C, Kara F, Martinet O, Ganster F, Navellou JC, et al.: Profile of the risk of death after septic shock in the present era: an epidemiologic study. Crit Care Med 2013, 41: 2600–9. 10.1097/CCM.0b013e31829a6e89
Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, et al.: Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med 2002, 28: 108–21. 10.1007/s00134-001-1143-z
Landelle C, Lepape A, Francais A, Tognet E, Thizy H, Voirin N, et al.: Nosocomial infection after septic shock among intensive care unit patients. Infect Control Hosp Epidemiol 2008, 29: 1054–65. 10.1086/591859
Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM, et al.: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999, 27: 1230–51. 10.1097/00003246-199907000-00002
Meakins JL, Pietsch JB, Bubenick O, Kelly R, Rode H, Gordon J, et al.: Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg 1977, 186: 241–50. 10.1097/00000658-197709000-00002
Christou NV, Meakins JL, Gordon J, Yee J, Hassan-Zahraee M, Nohr CW, et al.: The delayed hypersensitivity response and host resistance in surgical patients. 20 years later. Ann Surg 1995, 222: 534–46.
Munoz C, Carlet J, Fitting C, Misset B, Bleriot JP, Cavaillon JM: Dysregulation of in vitro cytokine production by monocytes during sepsis. J Clin Invest 1991, 88: 1747–54. 10.1172/JCI115493
Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, et al.: Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306: 2594–605. 10.1001/jama.2011.1829
Hotchkiss RS, Monneret G, Payen D: Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013, 13: 862–74. 10.1038/nri3552
Landelle C, Lepape A, Voirin N, Tognet E, Venet F, Bohe J, et al.: Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med 2010, 36: 1859–66. 10.1007/s00134-010-1962-x
Grimaldi D, Louis S, Pène F, Sirgo G, Rousseau C, Claessens YE, et al.: Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock. Intensive Care Med 2011, 37: 1438–46. 10.1007/s00134-011-2306-1
Grimaldi D, Le Bourhis L, Sauneuf B, Dechartres A, Rousseau C, Ouaaz F, et al.: Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections. Intensive Care Med 2014, 40: 192–201. 10.1007/s00134-013-3163-x
Benjamim CF, Hogaboam CM, Lukacs NW, Kunkel SL: Septic mice are susceptible to pulmonary aspergillosis. Am J Pathol 2003, 163: 2605–17. 10.1016/S0002-9440(10)63615-2
Pène F, Zuber B, Courtine E, Rousseau C, Ouaaz F, Toubiana J, et al.: Dendritic cells modulate lung response to Pseudomonas aeruginosa in a murine model of sepsis-induced immune dysfunction. J Immunol 2008, 181: 8513–20. 10.4049/jimmunol.181.12.8513
Docke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, et al.: Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997, 3: 678–81. 10.1038/nm0697-678
Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, et al.: Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009, 180: 640–8. 10.1164/rccm.200903-0363OC
Venet F, Foray AP, Villars-Mechin A, Malcus C, Poitevin-Later F, Lepape A, et al.: IL-7 restores lymphocyte functions in septic patients. J Immunol 2012, 189: 5073–81. 10.4049/jimmunol.1202062
Venet F, Lukaszewicz AC, Payen D, Hotchkiss R, Monneret G: Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies. Curr Opin Immunol 2013, 25: 477–83. 10.1016/j.coi.2013.05.006
Cavaillon JM, Eisen D, Annane D: Is boosting the immune system in sepsis appropriate? Crit Care 2014, 18: 216. 10.1186/cc13787
Hermans G, Casaer MP, Clerckx B, Guiza F, Vanhullebusch T, Derde S, et al.: Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. Lancet Respir Med 2013, 1: 621–9. 10.1016/S2213-2600(13)70183-8
Latronico N, Filosto M, Fagoni N, Gheza L, Guarneri B, Todeschini A, et al.: Small nerve fiber pathology in critical illness. PLoS One 2013, 8: e75696. 10.1371/journal.pone.0075696
Puthucheary ZA, McPhail MJ, Hart N: Acute muscle wasting among critically ill patients - reply. JAMA 2014, 311: 622–3. 10.1001/jama.2013.285426
Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, et al.: Acute skeletal muscle wasting in critical illness. JAMA 2013, 310: 1591–600. 10.1001/jama.2013.278481
de Jonghe B, Lacherade JC, Sharshar T, Outin H: Intensive care unit-acquired weakness: risk factors and prevention. Crit Care Med 2009, 37: S309–15. 10.1097/CCM.0b013e3181b6e64c
De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, et al.: Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002, 288: 2859–67. 10.1001/jama.288.22.2859
Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, et al.: One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003, 348: 683–93. 10.1056/NEJMoa022450
Sharshar T, Bastuji-Garin S, Stevens RD, Durand MC, Malissin I, Rodriguez P, et al.: Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality. Crit Care Med 2009, 37: 3047–53. 10.1097/CCM.0b013e3181b027e9
Latronico N, Bolton CF: Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol 2011, 10: 931–41. 10.1016/S1474-4422(11)70178-8
Batt J, Dos Santos CC, Cameron JI, Herridge MS: Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med 2013, 187: 238–46. 10.1164/rccm.201205-0954SO
Novak KR, Nardelli P, Cope TC, Filatov G, Glass JD, Khan J, et al.: Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats. J Clin Invest 2009, 119: 1150–8. 10.1172/JCI36570
Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, et al.: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360: 219–23. 10.1016/S0140-6736(02)09459-X
Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P, et al.: Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008, 358: 1327–35. 10.1056/NEJMoa070447
Supinski GS, Callahan LA: Diaphragmatic free radical generation increases in an animal model of heart failure. J Appl Physiol (1985) 2005, 99: 1078–84. 10.1152/japplphysiol.01145.2004
Polito A, Eischwald F, Maho AL, Azabou E, Annane D, Chretien F, et al.: Pattern of brain injury in the acute setting of human septic shock. Crit Care 2013, 17: R204. 10.1186/cc12899
Hermans G, De Jonghe B, Bruyninckx F, Van den Berghe G: Interventions for preventing critical illness polyneuropathy and critical illness myopathy. Cochrane Database Syst Rev 2014, 1: CD006832.
De Backer D, Donadello K, Taccone FS, Ospina-Tascon G, Salgado D, Vincent JL: Microcirculatory alterations: potential mechanisms and implications for therapy. Ann Intensive Care 2011, 1: 27. 10.1186/2110-5820-1-27
Walley KR: Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol (1985) 1996, 81: 885–94.
Schmidt H, Secchi A, Wellmann R, Bach A, Bohrer H, Gebhard MM, et al.: Effect of endotoxemia on intestinal villus microcirculation in rats. J Surg Res 1996, 61: 521–6. 10.1006/jsre.1996.0157
Piper RD, Pitt-Hyde ML, Anderson LA, Sibbald WJ, Potter RF: Leukocyte activation and flow behavior in rat skeletal muscle in sepsis. Am J Respir Crit Care Med 1998, 157: 129–34. 10.1164/ajrccm.157.1.9609012
Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288: 862–71. 10.1001/jama.288.7.862
De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL: Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002, 166: 98–104. 10.1164/rccm.200109-016OC
Trzeciak S, McCoy JV, Phillip Dellinger R, Arnold RC, Rizzuto M, Abate NL, et al.: Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008, 34: 2210–7. 10.1007/s00134-008-1193-6
Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, et al.: Sepsis in European intensive care units: results of the SOAP study. Crit Care Med 2006, 34: 344–53. 10.1097/01.CCM.0000194725.48928.3A
Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF: Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002, 360: 1395–6. 10.1016/S0140-6736(02)11393-6
De Backer D, Creteur J, Dubois MJ, Sakr Y, Koch M, Verdant C, et al.: The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006, 34: 403–8. 10.1097/01.CCM.0000198107.61493.5A
Ospina-Tascon G, Neves AP, Occhipinti G, Donadello K, Buchele G, Simion D, et al.: Effects of fluids on microvascular perfusion in patients with severe sepsis. Intensive Care Med 2010, 36: 949–55. 10.1007/s00134-010-1843-3
De Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent JL: Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 2006, 34: 1918–24. 10.1097/01.CCM.0000220498.48773.3C
Verdant CL, De Backer D, Bruhn A, Clausi CM, Su F, Wang Z, et al.: Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med 2009, 37: 2875–81. 10.1097/CCM.0b013e3181b029c1
Taccone FS, Su F, Pierrakos C, He X, James S, Dewitte O, et al.: Cerebral microcirculation is impaired during sepsis: an experimental study. Crit Care 2010, 14: R140. 10.1186/cc9205
Taccone FS, Su F, De Deyne C, Abdellhai A, Pierrakos C, He X, et al.: Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis. Crit Care Med 2014, 42: e114–22. 10.1097/CCM.0b013e3182a641b8
Schick MA, Isbary JT, Stueber T, Brugger J, Stumpner J, Schlegel N, et al.: Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents. BMC Gastroenterol 2012, 12: 179. 10.1186/1471-230X-12-179
Burban M, Hamel JF, Tabka M, de La Bourdonnaye MR, Duveau A, Mercat A, et al.: Renal macro- and microcirculation autoregulatory capacity during early sepsis and norepinephrine infusion in rats. Crit Care 2013, 17: R139. 10.1186/cc12818
Levin M, Quint PA, Goldstein B, Barton P, Bradley JS, Shemie SD, et al.: Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group. Lancet 2000, 356: 961–7. 10.1016/S0140-6736(00)02712-4
Angus DC, Birmingham MC, Balk RA, Scannon PJ, Collins D, Kruse JA, et al.: E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA 2000, 283: 1723–30. 10.1001/jama.283.13.1723
Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP, et al.: Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA 2013, 309: 1154–62. 10.1001/jama.2013.2194
Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA: A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987, 317: 653–8. 10.1056/NEJM198709103171101
Opal SM, Fisher CJ Jr, Dhainaut JF, Vincent JL, Brase R, Lowry SF, et al.: Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med 1997, 25: 1115–24. 10.1097/00003246-199707000-00010
Vincent JL, Spapen H, Bakker J, Webster NR, Curtis L: Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. Crit Care Med 2000, 28: 638–42. 10.1097/00003246-200003000-00006
Valenta J, Brodska H, Drabek T, Hendl J, Kazda A: High-dose selenium substitution in sepsis: a prospective randomized clinical trial. Intensive Care Med 2011, 37: 808–15. 10.1007/s00134-011-2153-0
Lukaszewicz AC, Grienay M, Resche-Rigon M, Pirracchio R, Faivre V, Boval B, et al.: Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction. Crit Care Med 2009, 37: 2746–52. 10.1097/CCM.0b013e3181ab858a