Bacterial and viral co-infections in patients with severe SARS-CoV-2 pneumonia admitted to a French ICU Tập 10 Số 1 - 2020
Damien Contou, Aurore Claudinon, Olivier Pajot, Maïté Micaëlo, Pascale Longuet Flandre, Grégory Ducrocq, Radj Cally, Elsa Logre, Megan Fraissé, Hervé Mentec, Gaëtan Plantefève
Abstract Background Data on the prevalence of bacterial and viral co-infections
among patients admitted to the ICU for acute respiratory failure related to
SARS-CoV-2 pneumonia are lacking. We aimed to assess the rate of bacterial and
viral co-infections, as well as to report the most common micro-organisms
involved in patients admitted to the ICU for severe SARS-CoV-2 pneumonia.
Patients and meth... hiện toàn bộ
Pilot trial of high-dose vitamin C in critically ill COVID-19 patients Tập 11 Số 1 - 2021
Jing Zhang, Xiaolan Rao, Yiming Li, Yibin Zhu, Fang Liu, Guangling Guo, Guopei Luo, Meng Zhao, Daniel De Backer, Hui Xiang, Zhiyong Peng
Abstract Background Few specific medications have been proven effective for the
treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we
tested whether high-dose vitamin C infusion was effective for severe COVID-19.
Methods This randomized, controlled, clinical trial was performed at 3 hospitals
in Hubei, China. Patients with confirmed severe acute respiratory syndrome
coron... hiện toàn bộ
Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review - 2020
Yasser Sakr, Manuela Giovini, Marc Léone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V. Marco Ranieri, Elio Antonucci
Abstract Background Preliminary reports have described significant procoagulant
events in patients with coronavirus disease-2019 (COVID-19), including
life-threatening pulmonary embolism (PE). Main text We review the current data
on the epidemiology, the possible underlying pathophysiologic mechanisms, and
the therapeutic implications of PE in relation to COVID-19. The incidence of PE
is reported ... hiện toàn bộ
Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review Tập 2 Số 1 - 2012
Fekade Bruck Sime, Michael S. Roberts, Sandra Peake, Jeffrey Lipman, Jason A. Roberts
Abstract The pharmacokinetics of beta-lactam antibiotics in intensive care
patients may be profoundly altered due to the dynamic, unpredictable
pathophysiological changes that occur in critical illness. For many drugs,
significant increases in the volume of distribution and/or variability in drug
clearance are common. When “standard” beta-lactam doses are used, such
pharmacokinetic changes can res... hiện toàn bộ
Ventilator-associated pneumonia in patients with SARS-CoV-2-associated acute respiratory distress syndrome requiring ECMO: a retrospective cohort study Tập 10 Số 1 - 2020
Charles Edouard Luyt, Tarek Sahnoun, Melchior Gautier, Pauline Vidal, Sonia Burrel, Marc Pineton de Chambrun, Juliette Chommeloux, Cyrielle Desnos, Jérémy Arzoine, Ania Nieszkowska, Nicolas Bréchot, Matthieu Schmidt, Guillaume Hékimian, David Boutolleau, Jérôme Robert, Alain Combes, Jean Chastre
Abstract Background The data on incidence, clinical presentation, and outcomes
of ventilator-associated pneumonia (VAP) in patients with severe coronavirus
disease 2019 (COVID-19) pneumonia requiring mechanical ventilation (MV) are
limited. We performed this retrospective cohort study to assess frequency,
clinical characteristics, responsible pathogens, and outcomes of VAP in patients
COVID-19 pne... hiện toàn bộ