American Society for Microbiology
1556-6811
1556-679X
Cơ quản chủ quản: N/A
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Các bài báo tiêu biểu
Acute Inflammatory Response to Endotoxin in Mice and HumansABSTRACT Endotoxin injection has been widely used to study the acute inflammatory response. In this study, we directly compared the inflammatory responses to endotoxin in mice and humans.Escherichia coli type O113 endotoxin was prepared under identical conditions, verified to be of equal biological potency, and used for both mice and humans... ...
Tập 12 Số 1 - Trang 60-67 - 2005
Proposed Model: Mechanisms of Immunomodulation Induced by Probiotic Bacteria
Tập 14 Số 5 - Trang 485-492 - 2007
Mastitis Increases Mammary mRNA Abundance of β-Defensin 5, Toll-Like-Receptor 2 (TLR2), and TLR4 but Not TLR9 in CattleABSTRACT Coordination of the primary defense mechanisms against pathogens relies on the appropriate expression of pathogen recognition receptors (PRRs) triggering the early release of effector molecules of the innate immune system. To analyze the impact of this system on the counteraction of infections of the mammary gland (mastitis), we characterized the bovine gen... ...
Tập 11 Số 1 - Trang 174-185 - 2004
Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young ChildrenABSTRACT The highly sensitive gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISPOT) assay permits the investigation of the role of cell-mediated immunity (CMI) in the protection of young children against influenza. Preliminary studies of young children confirmed that the IFN-γ ELISPOT assay was a more sensitive measure of influenza memory immune respon... ...
Tập 15 Số 7 - Trang 1042-1053 - 2008
Use of Opsonophagocytosis for Serological Evaluation of Pneumococcal Vaccines
Tập 13 Số 2 - Trang 165-169 - 2006
Characterization of a Mutant Escherichia coli Heat-Labile Toxin, LT(R192G/L211A), as a Safe and Effective Oral AdjuvantABSTRACT Despite the fact that the adjuvant properties of the heat-labile enterotoxins ofEscherichia coli (LT) andVibrio cholerae (CT) have been known for more than 20 years, there are no available oral vaccines containing these m... ...
Tập 18 Số 4 - Trang 546-551 - 2011
Prevalence and Molecular Characterization of Pertactin-Deficient Bordetella pertussis in the United StatesABSTRACT Pertussis has shown a striking resurgence in the United States, with a return to record numbers of reported cases as last observed in the 1950s.Bordetella pertussis isolates lacking pertactin, a key antigen component of the acellular pertussis vaccine, have been observed, suggesting that...
Tập 21 Số 2 - Trang 119-125 - 2014
Development and Validation of a Fourfold Multiplexed Opsonization Assay (MOPA4) for Pneumococcal AntibodiesABSTRACT
Opsonophagocytic killing assays (OPAs) are essential for developing and improving pneumococcal vaccines. There is a need for a high-throughput, reliable, standardized, and fully characterized OPA for pneumococcal antibodies. To meet the need, we have developed and characterized a fourfold multiplexed OPA (MOPA4) against 13 serotypes ... ...
Tập 13 Số 9 - Trang 1004-1009 - 2006
Multisite Comparison of High-Sensitivity Multiplex Cytokine AssaysABSTRACT
The concentrations of cytokines in human serum and plasma can provide valuable information about
in vivo
immune status, but low concentrations often require high-sensitivity assays to permit detection. The recent development of multiplex assays, which can measure multiple cytokines i... ...
Tập 18 Số 8 - Trang 1229-1242 - 2011
Monkeypox-Induced Immunity and Failure of Childhood Smallpox Vaccination To Provide Complete ProtectionABSTRACT
Following the U.S. monkeypox outbreak of 2003, blood specimens and clinical and epidemiologic data were collected from cases, defined by standard definition, and household contacts of cases to evaluate the role of preexisting (smallpox vaccine-derived) and acquired immunity in susceptibility to monkeypox disease and clinical outcomes. Orthopoxvir... ...
Tập 14 Số 10 - Trang 1318-1327 - 2007