American Society for Microbiology
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Acute Inflammatory Response to Endotoxin in Mice and Humans
American Society for Microbiology - Tập 12 Số 1 - Trang 60-67 - 2005
ABSTRACTEndotoxin injection has been widely used to study the acute inflammatory
response. In this study, we directly compared the inflammatory responses to
endotoxin in mice and humans.Escherichia colitype O113 endotoxin was prepared
under identical conditions, verified to be of equal biological potency, and used
for both mice and humans. The dose of endotoxin needed to induce an
interleukin-6 (I...
Human Immunodeficiency Virus Persistence and Production in T-Cell Development
American Society for Microbiology - Tập 13 Số 11 - Trang 1237-1245 - 2006
ABSTRACTHuman immunodeficiency virus type 1 (HIV-1) replication depends on CD4
and coreceptor expression as well as host factors associated with the activation
state of the cell. To determine the impact of the activation stage of thymocytes
on the HIV-1 life cycle, we investigated R5 and X4 HIV-1 entry, reverse
transcription, and expression in discrete thymocyte subsets at different stages
of T-ce...
Septic Shock after Seasonal Influenza Vaccination in an HIV-Infected Patient during Treatment with Etanercept for Rheumatoid Arthritis: a Case Report
American Society for Microbiology - Tập 20 Số 5 - Trang 761-764 - 2013
ABSTRACTAnti-tumor necrosis factor alpha (anti-TNF-α) is used in the treatment
of rheumatic diseases not responsive to first-line regimens. Data on the safety
of anti-TNF-α in HIV-infected patients are scarce and conflicting. We describe a
case of septic shock and multiorgan failure that occurred after etanercept
initiation and influenza vaccination in an HIV-infected woman with rheumatoid
arthrit...
Clearance of Virulent but Not AvirulentRhodococcus equifrom the Lungs of Adult Horses Is Associated with Intracytoplasmic Gamma Interferon Production by CD4+and CD8+T Lymphocytes
American Society for Microbiology - Tập 10 Số 2 - Trang 208-215 - 2003
ABSTRACTRhodococcus equiis a gram-positive bacterium that infects alveolar
macrophages and causes rhodococcal pneumonia in horses and humans. The virulence
plasmid ofR. equiappears to be required for both pathogenicity in the horse and
the induction of protective immunity. An understanding of the mechanisms by
which virulentR. equicircumvents protective host responses and by which bacteria
are ult...
Optimization and Validation of a Multiplex, Electrochemiluminescence-Based Detection Assay for the Quantitation of Immunoglobulin G Serotype-Specific Antipneumococcal Antibodies in Human Serum
American Society for Microbiology - Tập 16 Số 3 - Trang 387-396 - 2009
ABSTRACT Pneumovax 23 consists of a mixture of highly purified capsular
polysaccharides (Ps) from 23 of the most prevalent serotypes of Streptococcus
pneumoniae . Testing of vaccine immunogenicity has been historically performed
on the enzyme-linked immunosorbent assay (ELISA) platform, validated to measure
immunoglobulin G (IgG) antibodies to all 23 serotypes included in Pneumovax 23.
In order to...
Use of Opsonophagocytosis for Serological Evaluation of Pneumococcal Vaccines
American Society for Microbiology - Tập 13 Số 2 - Trang 165-169 - 2006
Development and Validation of a Fourfold Multiplexed Opsonization Assay (MOPA4) for Pneumococcal Antibodies
American Society for Microbiology - Tập 13 Số 9 - Trang 1004-1009 - 2006
ABSTRACT Opsonophagocytic killing assays (OPAs) are essential for developing and
improving pneumococcal vaccines. There is a need for a high-throughput,
reliable, standardized, and fully characterized OPA for pneumococcal antibodies.
To meet the need, we have developed and characterized a fourfold multiplexed OPA
(MOPA4) against 13 serotypes (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and
23F)...
Differentiation, Maturation, and Survival of Dendritic Cells by Osteopontin Regulation
American Society for Microbiology - Tập 12 Số 1 - Trang 206-212 - 2005
ABSTRACTDendritic cells (DCs) are antigen-presenting cells with the ability to
induce primary immune responses necessary in innate immunity and adaptive
immunity. Osteopontin (OPN) is a secreted acidic phosphoprotein containing an
arginine-glycine-aspartate sequence and has been suggested to play an important
role in early cellular immune responses. The interaction between DCs and OPN has
not been...
Microneedle Delivery of H5N1 Influenza Virus-Like Particles to the Skin Induces Long-Lasting B- and T-Cell Responses in Mice
American Society for Microbiology - Tập 17 Số 9 - Trang 1381-1389 - 2010
ABSTRACTA simple method suitable for self-administration of vaccine would
improve mass immunization, particularly during a pandemic outbreak. Influenza
virus-like particles (VLPs) have been suggested as promising vaccine candidates
against potentially pandemic influenza viruses, as they confer long-lasting
immunity but are not infectious. We investigated the immunogenicity and
protective efficacy ...
Use of an Inhibition Enzyme-Linked Immunosorbent Assay for Quantification of Capsular Polysaccharide or Proteins in Vaccines
American Society for Microbiology - Tập 14 Số 3 - Trang 323-327 - 2007
ABSTRACTAn inhibition enzyme-linked immunosorbent assay (ELISA) is described for
quantification of capsular polysaccharide or proteins in vaccines and other
samples containing whole cells or extracts ofActinobacillus pleuropneumoniae.
The assay can be used to quantify any antigen that can be purified and for which
highly specific antibodies are not available. The assay can be carried out by
any la...
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