American Journal of Cancer
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Current Status and Future Prospects of Gene Therapy
American Journal of Cancer - - 2012
Since the discovery of DNA and the subsequent recognition that genetic defects (either inherited or acquired) can be responsible for various disease states, the concept of gene therapy has been extremely appealing. However, despite intensive work in this field of medicine, gene therapy has yet to make a major impact on the treatment of patients. Many technical challenges exist that must be overcom......
Metastatic Prostate Cancer
American Journal of Cancer - Tập 2 - Trang 87-94 - 2012
The treatment of metastatic prostate cancer is based upon the principle that prostate cancer growth is stimulated by androgens. Androgen ablation therapy is an effective treatment for metastatic prostate cancer. The timing of initiation of androgen ablation and the role of combined androgen blockade have been investigated. The utilization of intermittent androgen suppression offers the potential f......
Pain control with zoledronic acid in patients with breast cancer and metastatic bone disease
American Journal of Cancer - Tập 3 - Trang 257-263 - 2012
Effective management of pain associated with metastatic bone disease is paramount in the care of cancer patients. Bisphosphonates are recommended in treating skeletal complications and there is evidence that they also control pain. To investigate the effects of zoledronic acid, a potent nitrogen-containing bisphosphonate, in reducing pain in patients with advanced breast cancer and bone metastases......
Gemcitabine
American Journal of Cancer - Tập 4 - Trang 395-416 - 2012
Gemcitabine (Gemzar®), an intravenously administered deoxycitidine analog, is approved in the US and several European countries for the treatment of locally advanced (unresectable) or metastatic adenocarcinoma of the pancreas, including fluorouracil-refractory disease. Although gemcitabine demonstrates only modest activity against pancreatic tumors (like most other cytotoxic agents), and rarely pr......
Postmenopausal Metastatic Breast Cancer
American Journal of Cancer - - 2012
Endocrine therapy and chemotherapy play important roles in the management of postmenopausal women with metastatic breast cancer. This paper specifically reviews the indications and options for first-line treatment of metastatic breast cancer and recent advances are highlighted, with particular attention to randomized, controlled, phase III clinical trials. Until recently, tamoxifen was standard fi......
The Evolving Role of Aromatase Inhibitors in the Adjuvant Breast Cancer Setting
American Journal of Cancer - Tập 2 - Trang 13-18 - 2012
Third-generation aromatase inhibitors (AIs) have shown at least equivalent or superior efficacy to tamoxifen in the first-line treatment of women with hormone-dependent metastatic breast cancer. Similar results have been obtained in the neoadjuvant setting. These studies suggested that AIs may also have significant efficacy in the adjuvant setting, and evaluation against tamoxifen is ongoing. Unli......
Docetaxel
American Journal of Cancer - Tập 3 - Trang 325-332 - 2012
▴ Docetaxel is an antimicrotubule agent established as a first- and/or second-line intravenous therapy in a variety of cancers, including locally advanced or metastatic breast cancer. It also is approved in the US as adjuvant therapy in early breast cancer, and continues to be investigated in this setting in combination with other agents and in various dosing schedules. ▴ The efficacy of docetaxel......
Oral Chemotherapy for the Older Patient with Cancer
American Journal of Cancer - Tập 1 - Trang 101-108 - 2012
Oral chemotherapy presents a number of theoretical advantages in older cancer patients, including convenience of administration and dosage flexibility. Of the oral fluorinated pyrimidines, capecitabine is the most promising, because it minimizes the exposure of normal tissue to the active drug and substantially reduces the risk of mucositis, that is particularly common and severe in the aged. Desp......
Tổng số: 166
- 1
- 2
- 3
- 4
- 5
- 6
- 10