American Journal of Cancer
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Current Status and Future Prospects of Gene Therapy
American Journal of Cancer - - 2012
Since the discovery of DNA and the subsequent recognition that genetic defects
(either inherited or acquired) can be responsible for various disease states,
the concept of gene therapy has been extremely appealing. However, despite
intensive work in this field of medicine, gene therapy has yet to make a major
impact on the treatment of patients. Many technical challenges exist that must
be overcom...
Metastatic Prostate Cancer
American Journal of Cancer - Tập 2 - Trang 87-94 - 2012
The treatment of metastatic prostate cancer is based upon the principle that
prostate cancer growth is stimulated by androgens. Androgen ablation therapy is
an effective treatment for metastatic prostate cancer. The timing of initiation
of androgen ablation and the role of combined androgen blockade have been
investigated. The utilization of intermittent androgen suppression offers the
potential f...
Pain control with zoledronic acid in patients with breast cancer and metastatic bone disease
American Journal of Cancer - Tập 3 - Trang 257-263 - 2012
Effective management of pain associated with metastatic bone disease is
paramount in the care of cancer patients. Bisphosphonates are recommended in
treating skeletal complications and there is evidence that they also control
pain. To investigate the effects of zoledronic acid, a potent
nitrogen-containing bisphosphonate, in reducing pain in patients with advanced
breast cancer and bone metastases...
Gemcitabine
American Journal of Cancer - Tập 4 - Trang 395-416 - 2012
Gemcitabine (Gemzar®), an intravenously administered deoxycitidine analog, is
approved in the US and several European countries for the treatment of locally
advanced (unresectable) or metastatic adenocarcinoma of the pancreas, including
fluorouracil-refractory disease. Although gemcitabine demonstrates only modest
activity against pancreatic tumors (like most other cytotoxic agents), and
rarely pr...
Postmenopausal Metastatic Breast Cancer
American Journal of Cancer - - 2012
Endocrine therapy and chemotherapy play important roles in the management of
postmenopausal women with metastatic breast cancer. This paper specifically
reviews the indications and options for first-line treatment of metastatic
breast cancer and recent advances are highlighted, with particular attention to
randomized, controlled, phase III clinical trials. Until recently, tamoxifen was
standard fi...
The Evolving Role of Aromatase Inhibitors in the Adjuvant Breast Cancer Setting
American Journal of Cancer - Tập 2 - Trang 13-18 - 2012
Third-generation aromatase inhibitors (AIs) have shown at least equivalent or
superior efficacy to tamoxifen in the first-line treatment of women with
hormone-dependent metastatic breast cancer. Similar results have been obtained
in the neoadjuvant setting. These studies suggested that AIs may also have
significant efficacy in the adjuvant setting, and evaluation against tamoxifen
is ongoing. Unli...
Docetaxel
American Journal of Cancer - Tập 3 - Trang 325-332 - 2012
▴ Docetaxel is an antimicrotubule agent established as a first- and/or
second-line intravenous therapy in a variety of cancers, including locally
advanced or metastatic breast cancer. It also is approved in the US as adjuvant
therapy in early breast cancer, and continues to be investigated in this setting
in combination with other agents and in various dosing schedules. ▴ The efficacy
of docetaxel...
Oral Chemotherapy for the Older Patient with Cancer
American Journal of Cancer - Tập 1 - Trang 101-108 - 2012
Oral chemotherapy presents a number of theoretical advantages in older cancer
patients, including convenience of administration and dosage flexibility. Of the
oral fluorinated pyrimidines, capecitabine is the most promising, because it
minimizes the exposure of normal tissue to the active drug and substantially
reduces the risk of mucositis, that is particularly common and severe in the
aged. Desp...
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