Alimentary Pharmacology and Therapeutics

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Long-term results of treatment of malignant carcinoid syndrome with prolonged release Lanreotide (Somatuline Autogel)
Alimentary Pharmacology and Therapeutics - Tập 34 Số 2 - Trang 235-242 - 2011
Mohid S. Khan, F. El-Khouly, Philippa Davies, Christos Toumpanakis, M. Caplin
Long‐term results of patients with malignant carcinoid syndrome receiving octreotide LAR
Alimentary Pharmacology and Therapeutics - Tập 30 Số 7 - Trang 733-740 - 2009
Christos Toumpanakis, J. Garland, Laura Marelli, Rajaventhan Srirajaskanthan, Jade Xiao Jue Soh, Philippa Davies, John Buscombe, Martyn Caplin
SummaryBackground  Octreotide LAR is an established treatment for malignant carcinoid syndrome. However, studies with large number of patients and long follow‐up are lacking.Aim  To present long‐terms results with octreotide LAR, assessing duration of clinical and objective response and treatment tolerance, in a large, homogeneous cohort of patients with malignant carcinoid syndrome.Methods  A tot... hiện toàn bộ
Sandostatin LAR (long‐acting octreotide acetate) for malignant carcinoid syndrome: a 3‐year experience
Alimentary Pharmacology and Therapeutics - Tập 17 Số 3 - Trang 437-444 - 2003
J. Garland, John Buscombe, Catherine Bouvier, Pierre‐Marc Bouloux, Michael H. Chapman, A. C. Chow, Nicola Reynolds, Martyn Caplin
SummaryBackground : Somatostatin analogues are the best therapy for controlling the symptoms of malignant carcinoid syndrome. Octreotide acetate given as subcutaneous injection up to three times daily, intramuscular Lanreotide injection given once per 1–2 weeks and monthly intramuscular Sandostatin LAR have demonstrated similar efficacy in short‐term studies.Aim : To assess the long‐term effect of... hiện toàn bộ
Gastric emptying and different types of reflux in adult patients with cystic fibrosis
Alimentary Pharmacology and Therapeutics - Tập 34 Số 7 - Trang 799-807 - 2011
Ans Pauwels, Kathleen Blondeau, Veerle Mertens, Ricard Farré, Kristin Verbeke, Lieven Dupont, Daniel Sifrim
Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome
Alimentary Pharmacology and Therapeutics - Tập 42 Số 4 - Trang 418-427 - 2015
Bruno P. Chumpitazi, Julia Cope, Emily B. Hollister, Chun-Ming Tsai, Ann R. McMeans, Renato A. Luna, James Versalovic, Robert J. Shulman
SummaryBackgroundA low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) within 48 h.AimTo determine the efficacy of a low FODMAP diet in childhood IBS and whether gut microbial composition and/or metabolic capacity are associated with its efficacy.MethodsIn a double‐blind, crossover trial, childre... hiện toàn bộ
Review article: is non‐alcoholic fatty liver disease a spectrum, or are steatosis and non‐alcoholic steatohepatitis distinct conditions?
Alimentary Pharmacology and Therapeutics - Tập 36 Số 9 - Trang 815-823 - 2012
Yusuf Yılmaz
SummaryBackgroundNon‐alcoholic fatty liver disease (NAFLD) is currently conceptualised as a clinical spectrum that results from a ‘multiple‐hit’ process which begins with simple steatosis and subsequently renders the hepatocytes susceptible to a variety of insults. Ultimately, more serious liver injuries like non‐alcoholic steatohepatitis (NASH) and cirrhosis may develop. Although the metabolic sy... hiện toàn bộ
Short‐chain fatty acid topical treatment in distal ulcerative colitis
Alimentary Pharmacology and Therapeutics - Tập 9 Số 3 - Trang 309-313 - 1995
P. Vernia, Adriana Marcheggiano, R. Caprilli, Giuseppe Frieri, Giovanni Corrao, D. Valpiani, M.C. Di Paolo, P. Paoluzi, A Torsoli
SUMMARY Background: Some evidence indicates that short‐chain fatty acid (SCFA) enemas are effective in the treatment of distal ulcerative colitis. Methods: In a randomized, double‐blind, placebo‐controlled study, we tested the efficacy of a 6‐week course of topical SCFA (100 mL, twice daily enemas of sodium acetate 80 mmol/L, sodium propionate 30 mmol/L and sodium butyrate 40 mmol/L) in 40 patient... hiện toàn bộ
Review article: chronic viral infection in the anti‐tumour necrosis factor therapy era in inflammatory bowel disease
Alimentary Pharmacology and Therapeutics - Tập 31 Số 1 - Trang 20-34 - 2010
Matthew Shale, Cynthia H. Seow, Carla S. Coffin, Gilaad G. Kaplan, Remo Panaccione, Subrata Ghosh
SummaryBackground  Anti‐Tumour necrosis factor (TNF) therapy is now well established in the treatment of inflammatory bowel disease and the risk of opportunistic infection is recognized. However, specific considerations regarding screening, detection, prevention and treatment of chronic viral infections in the context of anti‐TNF therapy in inflammatory bowel disease are not widely adopted in prac... hiện toàn bộ
Ambulatory gastric pH monitoring: proper probe placement and normal values
Alimentary Pharmacology and Therapeutics - Tập 15 Số 8 - Trang 1155-1162 - 2001
William K. Fackler, Michael F. Vaezi, Joel E. Richter
Background: Gastric acid production may persist while patients are treated with proton pump inhibitors. Twenty‐four‐hour intragastric pH monitoring is being used to identify gastric acid in the stomach while on medical therapy.Aim: To identify the optimal region of the stomach to demonstrate the presence of gastric acid.Method: Probe locations confirmed with fluoroscopy after placement and prior t... hiện toàn bộ
Comparison of gastric emptying of a nondigestible capsule to a radio‐labelled meal in healthy and gastroparetic subjects
Alimentary Pharmacology and Therapeutics - Tập 27 Số 2 - Trang 186-196 - 2008
Braden Kuo, Richard W. McCallum, Kenneth L. Koch, Michael D. Sitrin, John M. Wo, William D. Chey, William L. Hasler, Jeffrey M. Lackner, Leonard Katz, John R. Semler, Gregory E. Wilding, Henry P. Parkman
SummaryBackground  Gastric emptying scintigraphy (GES) using a radio‐labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET).Aims  To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discr... hiện toàn bộ
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