Short‐chain fatty acid topical treatment in distal ulcerative colitis

Alimentary Pharmacology and Therapeutics - Tập 9 Số 3 - Trang 309-313 - 1995
P. Vernia1, Adriana Marcheggiano1, R. Caprilli2, Giuseppe Frieri2, Giovanni Corrao3, D. Valpiani4, M.C. Di Paolo1, P. Paoluzi1, A Torsoli1
1Cattedra di Gastroenterologia 1, Univesità La Sapienza, Roma
2Cattedra di Gastroenterologia, Università de L'Aquila
3Istitudoi Scienze Statistiche, Universita di Milano, Italy
4Divisione di Gastroenterologia Ospedale Civile Forll

Tóm tắt

SUMMARY Background: Some evidence indicates that short‐chain fatty acid (SCFA) enemas are effective in the treatment of distal ulcerative colitis. Methods: In a randomized, double‐blind, placebo‐controlled study, we tested the efficacy of a 6‐week course of topical SCFA (100 mL, twice daily enemas of sodium acetate 80 mmol/L, sodium propionate 30 mmol/L and sodium butyrate 40 mmol/L) in 40 patients with mild to moderate distal colitis. Clinical, endoscopic and histological data were collected at the beginning and end of the study. Results: Fourteen patients on SCFA improved (overall score 11.3 ± 2.0 vs. 7.4 ± 3.5) as compared to five in the placebo group (overall score 10.0 ± 1.9 vs. 8.9 ± 2.5). In the SCFA‐treated group all parameters significantly improved except the number of bowel motions, whereas no significant changes were recorded in the control group. A statistically significant difference between the two treatment regimens, however, was observed only for intestinal bleeding (P < 0.05), urgency (P < 0.02) and the patient self‐evaluation score (P < 0.05). This was probably due to the random inclusion of more patients with moderate disease into the SCFA‐treated group, thus causing pre‐trial differences between the two groups. Conclusion: the present study confirms that irrigation with SCFA enemas is effective in distal colitis, and may represent an alternative therapeutic tool in the treatment of the disease.

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Tài liệu tham khảo

10.1136/gut.21.9.793

10.1016/S0140-6736(80)91934-0

10.1136/gut.35.1.73

10.1093/ajcn/29.12.1333

10.1016/S0016-5085(88)80078-7

Vernia P, 1991, Organic anions and the diarrhoea of inflammatory bowel disease, Dig Dis Sci, 36, 185

10.1007/BF01300754

10.1016/0016-5085(92)91094-K

10.1007/BF02253492

10.1093/ajcn/39.2.338

10.1177/0148607189013002109

10.1016/0092-8674(75)90107-5

Kruh J., 1982, Effects of sodium butyrate, a new pharmacological agent, on cells in culture, Molec Cell Biochem, 42, 65

10.1002/tcm.1770130204

Sakata T, 1991, Short‐Chain Fatty Acids: Metabolism and Clinical Im portance, 63

10.1016/0016-5085(81)90066-4

10.1136/gut.31.12.1391

10.1016/0016-5085(94)90598-3

10.1097/00004836-199008000-00009

10.3109/00365529209165428

10.1007/BF02065414

Argenzio RA, 1975, Effect of volatile fatty acids on water and ion absorption from the goat colon, Am J Physiol, 229, 997, 10.1152/ajplegacy.1975.229.4.997

Ruppin H, 1980, Absorption of short‐chain fatty acids by the colon, Gastro enterology, 78, 1500, 10.1016/S0016-5085(19)30508-6

Tazume S, 1990, Ecological studies on intestinal microbial flora of Kenyan children with diarrhoea, J Trop Med Hyg, 15, 787

10.1136/gut.34.9.1215

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Thông tin xuất bản

Alimentary Pharmacology and Therapeutics

Tập 9 Số 3

309-313

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