Advances in Genetics
0065-2660
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31 From genetics to mechanism of disease liability
Tập 42 - Trang 517 - 2001
The molecular basis of single-gene Mendelian disorders resulting from gain or loss of function is being clarified at a rapid pace. Progress in the genetics of common disease, by contrast, has been frustratingly limited, as we discuss by reference to essential hypertension (EH). The application of standard genetic paradigms to hypertension research has yielded remarkable findings. Arterial pressure......
Combinatorial Associations Of Regulatory Proteins And The Control Of Cell Type In Yeast
Tập 27 - Trang 33-62 - 1990
Chapter 4 Genetics and Molecular Pathophysiology of Nav1.7‐Related Pain Syndromes
Tập 63 - Trang 85 - 2008
SCN9A, the gene which encodes voltage‐gated sodium channel Nav1.7, is located on human chromosome 2 within a cluster of other members of this gene family. Nav1.7 is present at high levels in most peripheral nociceptive neurons in dorsal root ganglion (DRG) and in sympathetic neurons. In addition to its focal tissue‐specific expression, Nav1.7 is distinguished by its ability to amplify small depola......