Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting Tập 9 Số 2 - Trang 195-204
Unnati Garg, Swati Chauhan, Upendra Nagaich, Neha Jain
Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve targeted delivery. Chitosan NPs being biodegradable, biocompatible, less toxic and easy to prepare, are an effective and potential tool for drug delivery. Chitosan is natural biopolymer which can be easily functionalized to obtain the ...... hiện toàn bộ Successful Application of Alpha Lipoic Acid Niosomal Formulation in Cerebral Ischemic Reperfusion Injury in Rat Model Tập 12 Số 3 - Trang 541-549 - 2022
Mohammad Amin Raeisi Estabragh, Abbas Pardakhty, Saeid Ahmadzadeh, Shahriar Dabiri, Hamid Reza Mollaei, Mohammad Mehdi Oloumi
Purpose: Free radicals such as hydroxyl and peroxide are contributing factors to neuronaldestruction in cerebral ischemia. Alpha-lipoic acid (ALA) is one of the potent knownantioxidants. Preparation of ALA niosomes allows IV injection and can increase bioavailabilityand penetration into the central nervous system (CNS).Methods: Film hydration method was used to prepare different niosomes c...... hiện toàn bộ Immunomodulatory Activities of Sambucus javanica Extracts in DMBAExposedBALB/c Mouse Tập 9 Số 4 - Trang 619-623
Wira Eka Putra, Muhaimin Rifa’i
Purpose: Accumulating evidence shows the genus of Sambucus exerts a broad spectrum ofmedicinal potencies such as anticancer, antiviral, antibacterial, and antidiabetes. Based on theprevious studies, we hypothesized that bioactive compounds of Sambucus might alter severalbiological systems, including the immune system. Therefore, this study extensively aimed toevaluate the immunomodulatory ...... hiện toàn bộ miR‐146a‐5p and miR-193a-5p Synergistically Inhibited the Proliferation of Human Colorectal Cancer Cells (HT-29 cell line) through ERK Signaling Pathway Tập 11 Số 4 - Trang 755-764 - 2020
Saeed Noorolyai, Elham Baghbani, Dariush Shanehbandi, Vahid Khaze, Amir Baghbanzadeh, Behzad Mansoori, Khalil Hajiasgharzadeh, Ahad Mokhtarzadeh, Behzad Baradaran
Purpose: The expression of miR-146a-5p and miR-193a-5p in colorectal cancer (CRC) is associated with cancer development, metastasis, and reduced survival rate of the tumor-suffered subjects. This examination aimed to assess the impact of these microRNAs (miRNAs) in CRC and their mechanisms in the proliferation and migration of cancer cells. Methods: miR-146a-5p and -193a-5p were transfecte...... hiện toàn bộ