Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure Tập 13 Số 2 - Trang 253-263 - 2008
Miriam Schneider
ABSTRACTDuring puberty, neuronal maturation of the brain, which began during perinatal development, is completed such that the behavioral potential of the adult organism can be fully achieved. These maturational events and processes of reorganization are needed for the occurrence of adult behavioral performance but simultaneously render the organism highly suscepti...... hiện toàn bộ Identifying the neural circuitry of alcohol craving and relapse vulnerability Tập 14 Số 1 - Trang 108-118 - 2009
Andreas Heinz, Anne Beck, Sabine M. Grüsser, Anthony A. Grace, Jana Wrase
ABSTRACTWith no further intervention, relapse rates in detoxified alcoholics are high and usually exceed 80% of all detoxified patients. It has been suggested that stress and exposure to priming doses of alcohol and to alcohol‐associated stimuli (cues) contribute to the relapse risk after detoxification. This article focuses on neuronal correlates of cue responses ...... hiện toàn bộ IMAGING STUDY: Prefrontal cortex morphometry in abstinent adolescent marijuana users: subtle gender effects Tập 14 Số 4 - Trang 457-468 - 2009
Krista M. Lisdahl, Tim McQueeny, Bonnie J. Nagel, Karen L. Hanson, Tony T. Yang, Susan F. Tapert
ABSTRACTAdult human studies suggest frontal dysfunction associated with chronic marijuana (MJ) use, but due to continued neuromaturation, adult studies may not generalize to adolescents. This study characterized prefrontal cortex (PFC) morphometry in chronic MJ‐using adolescents following 1 month of monitored abstinence. Data were collected from MJ users (... hiện toàn bộ Ethanol metabolism in the brain Tập 2 Số 4 - Trang 387-400 - 1997
С. М. Зиматкин, Richard A. Deitrich
AbstractAcetaldehyde is suspected of being involved in the central mechanism of central nervous system depression and addiction to ethanol, but in contrast to ethanol, it can not penetrate easily from blood into the brain because of metabolic barriers. Therefore, the possibility of ethanol metabolism and acetaldehyde formation inside the brain has been one of the c...... hiện toàn bộ Gender differences in the pharmacology of nicotine addiction Tập 3 Số 4 - Trang 383-404 - 1998
Neal L. Benowitz, Dorothy K. Hatsukami
AbstractSmoking rates have declined in recent years less rapidly in women than in men. More adolescent girls than boys are currently smoking. Quitting smoking is reported in many studies to be more difficult in women than in men. These observations suggest that there may be gender differences in the nature of nicotine addiction. Gender differences in various pharma...... hiện toàn bộ Advances in the field of cannabinoid–opioid cross‐talk Tập 13 Số 2 - Trang 213-224 - 2008
Patricia Robledo, Fernando Berrendero, Andrés Ozaita, Rafaël Maldonado
ABSTRACTA remarkable amount of literature has been generated demonstrating the functional similarities between the endogenous opioid and cannabinoid systems. Anatomical, biochemical and molecular data support the existence of reciprocal interactions between these two systems related to several pharmacological responses including reward, cognitive effects, and the d...... hiện toàn bộ The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety Tập 17 Số 3 - Trang 634-647 - 2012
Jesse R. Schank, Andrea Goldstein Shipper, Kelly E. Rowe, Courtney King, Julie A. Marusich, Jenny L. Wiley, F. Ivy Carroll, Annika Thorsell, Markus Heilig
ABSTRACTThe role of kappa‐opioid receptors (KOR) in the regulation of alcohol‐related behaviors is not completely understood. For example, alcohol consumption has been reported to increase following treatment with KOR antagonists in rats, but was decreased in mice with genetic deletion of KOR. Recent studies have further suggested that KOR antagonists may selective...... hiện toàn bộ