Acta Pharmaceutica

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Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety
Acta Pharmaceutica - Tập 63 Số 2 - Trang 231-239 - 2013
Priya V. Frank, Mahesha M. Poojary, Damodara Naral, Chandrashekhar Chikkanna
3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the ti...... hiện toàn bộ
Metal ions, Alzheimer's disease and chelation therapy
Acta Pharmaceutica - Tập 61 Số 1 - Trang 1-14 - 2011
Ana Budimir
Metal ions, Alzheimer's disease and chelation therapyIn the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration is an ...... hiện toàn bộ
Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib
Acta Pharmaceutica - Tập 57 Số 3 - Trang 315-332 - 2007
Sanjula Baboota, Faiyaz Shakeel, Alka Ahuja, Javed Ali, Sheikh Shafiq
Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxibThe aim of the present study was to investigate the potential of nanoemulsion formulations for transdermal delivery of celecoxib (CXB). Thein vitroskin permeation profile of optimized formulations was compared with CXB gel and nanoe...... hiện toàn bộ
Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method
Acta Pharmaceutica - Tập 66 Số 1 - Trang 119-128 - 2016
Bożena Karolewicz, Karol P. Nartowski, Janusz Pluta, Agata Górniak
Abstract The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and ch...... hiện toàn bộ
Ordered mesoporous silicates as matrices for controlled release of drugs
Acta Pharmaceutica - Tập 60 Số 4 - Trang 373-385 - 2010
Tina Ukmar, Odon Planinšek
Ordered mesoporous silicates as matrices for controlled release of drugs Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how ...... hiện toàn bộ
The technologies used for developing orally disintegrating tablets: A review
Acta Pharmaceutica - Tập 61 Số 2 - Trang 117-139 - 2011
Bhatu Badgujar, Atish S. Mundada
The technologies used for developing orally disintegrating tablets: A reviewOrally disintegrating tablets (ODTs), also known as fast melts, quick melts, fast disintegrating and orodispersible systems, have the unique property of disintegrating in the mouth in seconds without chewing and the need of water and are thus assumed to improve patient compliance. Conventio...... hiện toàn bộ
Eudragit S-100 coated sodium alginate microspheres of naproxen sodium: Formulation, optimization and in vitro evaluation / Alginatne mikrosfere naproksen natrija obložene Eudragitom S-100: Priprava, optimizacija i in vitro vrednovanje
Acta Pharmaceutica - Tập 62 Số 4 - Trang 529-545 - 2012
Anuj Chawla, Pooja Sharma, Pravin Pawar
The aim of the study was to prepare site specific drug delivery of naproxen sodium using sodium alginate and Eudragit S-100 as a mucoadhesive and pH-sensitive polymer, respectively. Core microspheres of alginate were prepared by a modified emulsification method followed by cross-linking with CaCl2, which was further coated with the pH dependent polymer Eudragit S-100 (...... hiện toàn bộ
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