Acta Neuropathologica Communications

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Brain tumor with an ATXN1-NUTM1 fusion gene expands the histologic spectrum of NUTM1-rearranged neoplasia
Acta Neuropathologica Communications - Tập 7 - Trang 1-3 - 2019
Aurore Siegfried, Julien Masliah-Planchon, Franck-Emmanuel Roux, Delphine Larrieu-Ciron, Gaelle Pierron, Yvan Nicaise, Marion Gambart, Isabelle Catalaa, Sarah Péricart, Charlotte Dubucs, Badreddine Mohand-Oumoussa, Franck Tirode, Franck Bourdeaut, Emmanuelle Uro-Coste
CNS-associated macrophages contribute to intracerebral aneurysm pathophysiology
Acta Neuropathologica Communications - Tập 12 Số 1
Martina Glavan, Andrea Jelić, Damien Levard, Juhana Frösén, Sara Keränen, Bart A. A. Franx, Ana Rita Brás, Estelle R Louet, Ádám Dénes, Mario Merlini, Denis Vivien, Marina Rubio
AbstractIntracerebral aneurysms (IAs) are pathological dilatations of cerebral arteries whose rupture leads to subarachnoid hemorrhage, a significant cause of disability and death. Inflammation is recognized as a critical contributor to the formation, growth, and rupture of IAs; however, its precise actors have not yet been fully elucidated. Here, we report CNS-ass...... hiện toàn bộ
α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Acta Neuropathologica Communications - Tập 9 - Trang 1-16 - 2021
Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanisms triggered by pathological aSyn accumulation, including impaired redox homeostasis, as significant...... hiện toàn bộ
PrPres deposition in the retina is a common finding of sporadic, familial and iatrogenic Creutzfeldt-Jakob diseases (CJD)
Acta Neuropathologica Communications - - 2018
Masaki Takao, Hiroaki Kimura, Tetsuyuki Kitamoto, Ban Mihara
Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
Acta Neuropathologica Communications - Tập 6 - Trang 1-17 - 2018
Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno, Dariusz C. Górecki
Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated by sterile inflammation and is also associated with cognitive impairment and low bone density. Given that no current treatment can improve the long-term outcome, approaches with a strong tran...... hiện toàn bộ
ALS-linked misfolded SOD1 species have divergent impacts on mitochondria
Acta Neuropathologica Communications - Tập 4 - Trang 1-14 - 2016
Sarah Pickles, Sabrina Semmler, Helen R. Broom, Laurie Destroismaisons, Laurine Legroux, Nathalie Arbour, Elizabeth Meiering, Neil R. Cashman, Christine Vande Velde
Approximately 20 % of familial Amyotrophic Lateral Sclerosis (ALS) is caused by mutations in superoxide dismutase (SOD1), which leads to misfolding of the SOD1 protein, resulting in a toxic gain of function. Several conformation-restricted antibodies have been generated that specifically recognize misfolded SOD1 protein, and have been used as therapeutics in pre-clinical models. Misfolded SOD1 sel...... hiện toàn bộ
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma
Acta Neuropathologica Communications -
Ahmad Joshkon, Émeline Tabouret, Waël Traboulsi, Richard Bachelier, Stéphanie Simoncini, Sandrine Roffino, Carine Jiguet-Jiglaire, Bassam Badran, Benjamin Guillet, Alexandrine Foucault‐Bertaud, Aurélie S. Leroyer, Françoise Dignat‐George, Olivier Chinot, Hussein Fayyad‐Kazan, Nathalie Bardin, Marcel Blot‐Chabaud
Abstract Rationale Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this treatment is frequent and fails to enhance the overall survival of...... hiện toàn bộ
The impairment of intramural periarterial drainage in brain after subarachnoid hemorrhage
Acta Neuropathologica Communications - Tập 10 - Trang 1-18 - 2022
Yanrong Sun, E. Liu, Yanhong Pei, Qinhan Yao, Haowen Ma, Yakun Mu, Yingjie Wang, Yan Zhang, Xiaomei Yang, Xing Wang, Jiajia Xue, Jiliang Zhai, Roxana O. Carare, Lihua Qin, Junhao Yan
Interstitial fluid (ISF) from brain drains along the basement membranes of capillaries and arteries as Intramural Periarterial Drainage (IPAD); failure of IPAD results in cerebral amyloid angiopathy (CAA). In this study, we test the hypothesis that IPAD fails after subarachnoid haemorrhage (SAH). The rat SAH model was established using endovascular perforation method. Fluorescence dyes with variou...... hiện toàn bộ
Mutation and expression analysis in medulloblastoma yields prognostic variants and a putative mechanism of disease for i17q tumors
Acta Neuropathologica Communications - Tập 2 - Trang 1-12 - 2014
Gabriel A Bien-Willner, Robi D Mitra
Current consensus identifies four molecular subtypes of medulloblastoma (MB): WNT, sonic hedgehog (SHH), and groups “3/C” and “4/D”. Group 4 is not well characterized, but harbors the most frequently observed chromosomal abnormality in MB, i17q, whose presence may confer a worse outcome. Recent publications have identified mutations in chromatin remodeling genes that may be overrepresented in this...... hiện toàn bộ
ATRX immunostaining predicts IDH and H3F3A status in gliomas
Acta Neuropathologica Communications - Tập 4 - Trang 1-10 - 2016
Azadeh Ebrahimi, Marco Skardelly, Irina Bonzheim, Ines Ott, Helmut Mühleisen, Franziska Eckert, Ghazaleh Tabatabai, Jens Schittenhelm
Gliomas are the most frequent intraaxial CNS neoplasms with a heterogeneous molecular background. Recent studies on diffuse gliomas have shown frequent alterations in the genes involved in chromatin remodelling pathways such as α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX). Yet, the reliability of ATRX in predicting isocitrate dehydrogenase (IDH) and H3 histone, family 3A (H3F3A) ...... hiện toàn bộ
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