Acta Neuropathologica Communications
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The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer diseaseAbstract Despite the increasing demographic diversity of the United States’ aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most autopsy-based studies have focused on cohorts of non-Hispanic White decedents (NHWD), with few studies includ... ... hiện toàn bộ
Acta Neuropathologica Communications - Tập 11 Số 1
Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease
Acta Neuropathologica Communications - Tập 6 - Trang 1-10 - 2018
Alzheimer’s disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its understanding crucial for developing new diagnostic and therapeutic approaches. Recent literature suggests that ageing may induce post translational modifications in Aβ, in the form of spontaneous amino acid modifications, wh...... hiện toàn bộ
Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in miceAbstract The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain barrier, posing a particular challenge for treatment. We report biological features of invasive growth... ... hiện toàn bộ
Acta Neuropathologica Communications - - 2021
Optimization of electron microscopy for human brains with long-term fixation and fixed-frozen sections
Acta Neuropathologica Communications - Tập 2 - Trang 1-10 - 2014
Abnormal connectivity across brain regions underlies many neurological disorders including multiple sclerosis, schizophrenia and autism, possibly due to atypical axonal organization within white matter. Attempts at investigating axonal organization on post-mortem human brains have been hindered by the availability of high-quality, morphologically preserved tissue, particularly for neurodevelopment...... hiện toàn bộ
Membrane binding, internalization, and sorting of alpha-synuclein in the cell
Acta Neuropathologica Communications - Tập 6 - Trang 1-17 - 2018
Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related to vesicle binding and trafficking, the precise molecular mechanisms linking aSyn with synucleinopathies are still obscure. aSyn can spread in a prion-like manner between inter...... hiện toàn bộ
Complement activation in multiple sclerosis plaques: an immunohistochemical analysis
Acta Neuropathologica Communications - Tập 2 Số 1 - 2014
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
Acta Neuropathologica Communications - Tập 7 - Trang 1-15 - 2019
Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia considered to be the potential neurotoxic species at late disease stages. Recent investigations have provided substantial evidence that a proinflammatory microglial cytokine cocktail containing TN...... hiện toàn bộ
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas
Acta Neuropathologica Communications - Tập 10 - Trang 1-11 - 2022
Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular landscape of sLGGs, we integrated clinical data, histology, and multi-level genetic and epigenetic analyses on a consecutive cohort of 26 pediatric patients. Driver molecular alter...... hiện toàn bộ
What is the evidence that tau pathology spreads through prion-like propagation?
Acta Neuropathologica Communications - Tập 5 - Trang 1-20 - 2017
Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propagation could occur through a “prion-like” mechanism involving transfer of abnormal tau seeds from a “donor cell” to a “recipient cell” and recruitment of normal tau in the latter to generate ne...... hiện toàn bộ
Letter to the editor on: Hornerin deposits in neuronal intranuclear inclusion disease: direct identification of proteins with compositionally biased regions in inclusions by Park et al. (2022)
Acta Neuropathologica Communications -
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