Acta Neuropathologica Communications

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α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Acta Neuropathologica Communications - Tập 9 - Trang 1-16 - 2021
Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanisms triggered by pathological aSyn accumulation, including impaired redox homeostasis, as significant...... hiện toàn bộ
PrPres deposition in the retina is a common finding of sporadic, familial and iatrogenic Creutzfeldt-Jakob diseases (CJD)
Acta Neuropathologica Communications - - 2018
Masaki Takao, Hiroaki Kimura, Tetsuyuki Kitamoto, Ban Mihara
Soluble CD146, a biomarker and a target for preventing resistance to anti-angiogenic therapy in glioblastoma
Acta Neuropathologica Communications -
Ahmad Joshkon, Émeline Tabouret, Waël Traboulsi, Richard Bachelier, Stéphanie Simoncini, Sandrine Roffino, Carine Jiguet-Jiglaire, Bassam Badran, Benjamin Guillet, Alexandrine Foucault‐Bertaud, Aurélie S. Leroyer, Françoise Dignat‐George, Olivier Chinot, Hussein Fayyad‐Kazan, Nathalie Bardin, Marcel Blot‐Chabaud
Abstract Rationale Glioblastoma multiforme (GBM) is a primary brain tumor with poor prognosis. The U.S. food and drug administration approved the use of the anti-VEGF antibody bevacizumab in recurrent GBM. However, resistance to this treatment is frequent and fails to enhance the overall survival of...... hiện toàn bộ
Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
Acta Neuropathologica Communications - Tập 9 - Trang 1-18 - 2021
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Chern
Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in the brain of AD patients while consequences remained ill-defined. Herein, we aimed at investigating whether manipulation of adenosine tone would impact Tau pathology, associated molecular al...... hiện toàn bộ
Correction to: Differential gene methylation and expression of HOX transcription factor family in orbitofacial neurofibroma
Acta Neuropathologica Communications - Tập 8 - Trang 1-1 - 2020
Antje Arnold, Eddie Luidy Imada, M. Lisa Zhang, Deepak P. Edward, Luigi Marchionni, Fausto J. Rodriguez
An amendment to this paper has been published and can be accessed via the original article.
FMRpolyG-positive inclusions in CNS and non-CNS organs of a fragile X premutation carrier with fragile X-associated tremor/ataxia syndrome
Acta Neuropathologica Communications - Tập 2 - Trang 1-5 - 2014
Ronald AM Buijsen, Chantal Sellier, Lies-Anne WFM Severijnen, Mustapha Oulad-Abdelghani, Rob FM Verhagen, Robert F Berman, Nicolas Charlet-Berguerand, Rob Willemsen, Renate K Hukema
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Optimization of electron microscopy for human brains with long-term fixation and fixed-frozen sections
Acta Neuropathologica Communications - Tập 2 - Trang 1-10 - 2014
Xiao-Bo Liu, Cynthia M Schumann
Abnormal connectivity across brain regions underlies many neurological disorders including multiple sclerosis, schizophrenia and autism, possibly due to atypical axonal organization within white matter. Attempts at investigating axonal organization on post-mortem human brains have been hindered by the availability of high-quality, morphologically preserved tissue, particularly for neurodevelopment...... hiện toàn bộ
Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Acta Neuropathologica Communications - Tập 9 - Trang 1-19 - 2021
Lanyu Zhang, Juan I. Young, Lissette Gomez, Tiago C. Silva, Michael A. Schmidt, Jesse Cai, Xi Chen, Eden R. Martin, Lily Wang
Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD), but the regulatory mechanisms underlying sex disparity in AD are still not well understood. DNA methylation is an important epigenetic modification that regulates gene transcription and is known to be involved in AD. We performed the first large-scale sex-specific meta-analysis o...... hiện toàn bộ
Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis
Acta Neuropathologica Communications - Tập 1 - Trang 1-9 - 2013
Axel Freischmidt, Kathrin Müller, Albert C Ludolph, Jochen H Weishaupt
A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caused by TDP-43 mutations. TDP-43 is involved in processing of both coding RNAs and microRNAs, which are key epigenetic regulators of transcriptome plasticity and suspected to contribute to neur...... hiện toàn bộ
Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
Acta Neuropathologica Communications - Tập 9 - Trang 1-15 - 2021
Alison M. Maxwell, Peng Yuan, Brianna M. Rivera, Wilder Schaaf, Mihovil Mladinov, Vee P. Prasher, Andrew C. Robinson, William F. DeGrado, Carlo Condello
Amyloid beta (Aβ) is thought to play a critical role in the pathogenesis of Alzheimer’s disease (AD). Prion-like Aβ polymorphs, or “strains”, can have varying pathogenicity and may underlie the phenotypic heterogeneity of the disease. In order to develop effective AD therapies, it is critical to identify the strains of Aβ that might arise prior to the onset of clinical symptoms and understand how ...... hiện toàn bộ
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