Cerebral organoids: emerging ex vivo humanoid models of glioblastoma

Acta Neuropathologica Communications - Tập 8 - Trang 1-9 - 2020
Michail-Dimitrios Papaioannou1,2, Kevin Sangster1,3, Rifat Shahriar Sajid1,3, Ugljesa Djuric1,2, Phedias Diamandis1,2,3,4
1Princess Margaret Cancer Centre, Toronto, Canada
2Laboratory Medicine Program, Department of Pathology, University Health Network, Toronto, Canada
3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
4Department of Medical Biophysics, University of Toronto, Toronto, Canada

Tóm tắt

Glioblastoma is an aggressive form of brain cancer that has seen only marginal improvements in its bleak survival outlook of 12–15 months over the last forty years. There is therefore an urgent need for the development of advanced drug screening platforms and systems that can better recapitulate glioblastoma’s infiltrative biology, a process largely responsible for its relentless propensity for recurrence and progression. Recent advances in stem cell biology have allowed the generation of artificial tridimensional brain-like tissue termed cerebral organoids. In addition to their potential to model brain development, these reagents are providing much needed synthetic humanoid scaffolds to model glioblastoma’s infiltrative capacity in a faithful and scalable manner. Here, we highlight and review the early breakthroughs in this growing field and discuss its potential future role for glioblastoma research.

Tài liệu tham khảo

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