3D printing technologies are emerging as a disruptive innovation for the
treatment of patients in cardiac failure. The ability to create custom devices,
at the point of care, will affect both the diagnosis and treatment of cardiac
diseases. The introduction of bioinks containing cells and biomaterials and the
development of new computer assisted design and computer assisted manufacturing
systems h... hiện toàn bộ
Collective motions of groups of cells are observed in many biological settings
such as embryo development, tissue formation, and cancer metastasis. To
effectively model collective cell movement, it is important to incorporate cell
specific features such as cell size, cell shape, and cell mechanics, as well as
active behavior of cells such as protrusion and force generation, contractile
forces, and... hiện toàn bộ
Hannah Viola, Jonathan Chang, Jocelyn R. Grunwell, Louise Hecker, Rabindra Tirouvanziam, James B. Grotberg, Shuichi Takayama
Complex in vitro models of the tissue microenvironment, termed
microphysiological systems, have enormous potential to transform the process of
discovering drugs and disease mechanisms. Such a paradigm shift is urgently
needed in acute respiratory distress syndrome (ARDS), an acute lung condition
with no successful therapies and a 40% mortality rate. Here, we consider how
microphysiological systems... hiện toàn bộ
Igor D. Luzhansky, Alyssa D. Schwartz, Joshua D. Cohen, John P. MacMunn, Lauren E. Barney, Lauren Jansen, Shelly R. Peyton
Appropriately chosen descriptive models of cell migration in biomaterials will
allow researchers to characterize and ultimately predict the movement of cells
in engineered systems for a variety of applications in tissue engineering. The
persistent random walk (PRW) model accurately describes cell migration on
two-dimensional (2D) substrates. However, this model inherently cannot describe
subdiffus... hiện toàn bộ