APL Bioengineering

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Epithelial vertex models with active biochemical regulation of contractility can explain organized collective cell motility
APL Bioengineering - Tập 2 Số 3 - 2018
Sarita Koride, Andrew J. Loza, Sean X. Sun
Collective motions of groups of cells are observed in many biological settings such as embryo development, tissue formation, and cancer metastasis. To effectively model collective cell movement, it is important to incorporate cell specific features such as cell size, cell shape, and cell mechanics, as well as active behavior of cells such as protrusion and force generation, contractile for...... hiện toàn bộ
Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair
APL Bioengineering - Tập 3 Số 4 - 2019
Hannah Viola, Jonathan Chang, Jocelyn R. Grunwell, Louise Hecker, Rabindra Tirouvanziam, James B. Grotberg, Shuichi Takayama
Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms. Such a paradigm shift is urgently needed in acute respiratory distress syndrome (ARDS), an acute lung condition with no successful therapies and a 40% mortality rate. Here, we consider how microphysiological...... hiện toàn bộ
Anomalously diffusing and persistently migrating cells in 2D and 3D culture environments
APL Bioengineering - Tập 2 Số 2 - 2018
Igor D. Luzhansky, Alyssa D. Schwartz, Joshua D. Cohen, John P. MacMunn, Lauren E. Barney, Lauren Jansen, Shelly R. Peyton
Appropriately chosen descriptive models of cell migration in biomaterials will allow researchers to characterize and ultimately predict the movement of cells in engineered systems for a variety of applications in tissue engineering. The persistent random walk (PRW) model accurately describes cell migration on two-dimensional (2D) substrates. However, this model inherently cannot describe s...... hiện toàn bộ
3D bioprinting and its potential impact on cardiac failure treatment: An industry perspective
APL Bioengineering - Tập 4 Số 1 - 2020
Ravi K. Birla, Stuart K. Williams
3D printing technologies are emerging as a disruptive innovation for the treatment of patients in cardiac failure. The ability to create custom devices, at the point of care, will affect both the diagnosis and treatment of cardiac diseases. The introduction of bioinks containing cells and biomaterials and the development of new computer assisted design and computer assisted manufacturing s...... hiện toàn bộ
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