AAPS PharmSci

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Low molecular weight protamine (LMWP) as nontoxic heparin/low molecular weight heparin antidote (II): In vitro evaluation of efficacy and toxicity
AAPS PharmSci - Tập 3 - Trang 1-9 - 2001
Li-Chien Chang, Jun Feng Liang, Hsiao-Feng Lee, Lai Ming Lee, Victor C Yang
Patients undergoing anticoagulation with heparin or low molecular weight heparin (LMWH) require a superior antidote that possesses more selective biological actions and a better safety profile than protamine. We had previously developed 2 low molecular weight protamine (LMWP) fractions (TDSP4 and TDSP5) from thermolysin-digested protamine as potential nontoxie, heparin-neutralizing agents. In this... hiện toàn bộ
Activity and kinetics of dissociation and transfer of amphotericin B from a novel delivery form
AAPS PharmSci - Tập 1 - Trang 1-11 - 1999
Bradley Baas, katie Kindt, Angela Scott, Jessica Scott, Peter Mikulecky, Scott C. Hartsel
Recently it has been demonstrated that moderate heat treatment of Amphotericin B/deoxycholate solutions (HAmB-DOC) leads to a therapeutically interesting supramolecular rearrangement that can be observed by significant changes in light scattering, CD, and absorbance. In this study, we continue the investigation of the physical properties of this new form by evaluating the activity and kinetics of ... hiện toàn bộ
Population analysis of the pharmacokinetics and pharmacodynamics of RWJ-270201 (BCX-1812) in treating experimental influenza A and B virus in healthy volunteers
AAPS PharmSci - Tập 4 - Trang 1-10 - 2015
Ganesh R. Iyer, Sam Liao, Joseph Massarella
Our objective was to assess the pharmacokinetics and pharmacodynamics of RWJ-270201 (BCX-1812), an oral neuraminidase inibitor for the treatment of influenza A and B virus in healthy volunteers. This was a double-blind, randomized, placebocontrolled, parallel group study. A total of 80 adult male and female subjects were enrolled for the influenza A challenge study. This was a 5arm study (100 mg/q... hiện toàn bộ
Nonlinearity detection: Advantages of nonlinear mixed-effects modeling
AAPS PharmSci - Tập 2 Số 3 - Trang 114-123 - 2000
E. Niclas Jonsson, Mats O. Karlsson, Janet R. Wade
Solvation and hydration characteristics of ibuprofen and acetylsalicylic acid
AAPS PharmSci - Tập 6 - Trang 1-9 - 2015
German L. Perlovich, Sergey V. Kurkov, Andrey N. Kinchin, Annette Bauer-Brandl
Ibuprofen and acetylsalicylic acid were studied by thermoanalytical methods: sublimation calorimetry, solution calorimetry, and with respect to solubility. Upon measuring the temperature dependences of the saturated vapor pressure, enthalpies of sublimation, ΔH 0 , as well as the entropies of sublimation, ΔH 0 , and their respective relative fractions in the total process were calculated. The Gibb... hiện toàn bộ
Comparative evaluation of tableting compression behaviors by methods of internal and external lubricant addition: Inhibition of enzymatic activity of trypsin preparation by using external lubricant addition during the tableting compression process
AAPS PharmSci - Tập 3 - Trang 1-11 - 2001
Makoto Otsuka, Mitsuyo Sato, Yoshihisa Matsuda
This study evaluated tableting compression by using internal and external lubricant addition. The effect of lubricant addition on the enzymatic activity of trypsin, which was used as a model drug during the tableting compression process, was also investigated. The powder mixture (2% crystalline trypsin, 58% crystalline lactose, and 40% microcrystalline cellulose) was kneaded with 5% hydroxypropyl ... hiện toàn bộ
Rheology and stability of water-in-oil-in-water multiple emulsions containing Span 83 and Tween 80
AAPS PharmSci - Tập 5 Số 1 - Trang 62-73 - 2003
Jim Jiao, Diane J. Burgess
Human proton/oligopeptide transporter (POT) genes: Identification of putative human genes using bioinformatics
AAPS PharmSci - Tập 2 - Trang 1-22 - 2000
Christopher W. Botka, Thomas W. Wittig, Richard C. Graul, Carsten Uhd Nielsen, Wolfgang Sadée, Kazutaka Higaki, Gordon L. Amidon
Purpose: The proton-dependent oligopeptide transporters (POT) gene family currently consists of ∼70 cloned cDNAs derived from diverse organisms. In mammals, two genes encoding peptide transporters, PepT1 and PepT2 have been cloned in several species including humans, in addition to a rat histidine/peptide transporter (rPHT1). Because the Candida elegans genome contains five putative POT genes, we ... hiện toàn bộ
The venus flytrap of periplasmic binding proteins: An ancient protein module present in multiple drug receptors
AAPS PharmSci - Tập 1 Số 2 - Trang 7-26 - 1999
Christian B. Felder, Richard C. Graul, Alan Y. Lee, Hans-Peter Merkle, Wolfgang Sadée
The composite solubility versus pH profile and its role in intestinal absorption prediction
AAPS PharmSci - Tập 5 - Trang 1-15 - 2015
Barry A. Hendriksen, Manuel V. Sanchez Felix, Michael B. Bolger
The purpose of this study was to examine absorption of basic drugs as a function of the composite solubility curve and intestinally relevant pH by using a gastrointestinal tract (GIT) absorption simulation based on the advanced compartmental absorption and transit model. Absorption simulations were carried out for virtual monobasic drugs having a range of pKa, log D, and dose values as a function ... hiện toàn bộ
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