Proceedings IEEE International Symposium on Biomedical Imaging
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Simultaneous validation of image segmentation and assessment of expert quality [tumor MRI application]
- Trang 94-97
Characterizing the performance of image segmentation approaches has been a persistent challenge. Interactive drawing of the desired segmentation by domain experts has often been the only acceptable approach, and yet suffers from intra-expert and inter-expert variability. Algorithms have been sought in order to remove the variability introduced by experts. The accuracy of segmentations of medical i......
#Image segmentation #Biomedical imaging #Imaging phantoms #Volume measurement #Sensitivity and specificity #Surgery #Laboratories #Hospitals #Maximum likelihood estimation #Image recognition
The elastic reconstruction of soft tissues
- Trang 1035-1038
A finite element based nonlinear inverse scheme is presented to reconstruct the elastic properties of soft tissues subjected to an external compression. An objective function relating the least-square difference of model-predicted and measured displacement or strain fields from a sequence of images (B-mode or MRI) is minimized with respect to the unknown material parameters. To obtain physically m......
#Biological tissues #Image reconstruction #Strain measurement #Finite element methods #Image coding #Displacement measurement #Magnetic resonance imaging #Biological materials #Material properties #Constraint optimization
Rapid semi-automated segmentation and analysis of neuronal morphology and function from confocal image data
- Trang 233-236
Confocal microscopy combined with cellular labeling techniques can be an effective method for imaging the morphology of a cell as well as various functional characteristics in vivo. Current analysis methods are manual, and therefore, time-consuming and prone to error. Through the development of custom algorithms and application design, the analysis process can be improved to decrease analysis time......
#Image segmentation #Image analysis #Morphology #Algorithm design and analysis #Reproducibility of results #Application software #Microscopy #Labeling #In vivo #Process design
Design study of a novel dual-modality emission micro-imaging tomograph for radiopharmaceutical and bioluminescent/fluorescent molecular approaches
- Trang 797-800
We have designed, simulated, and propose to construct a novel dual-modality (multi-)pinhole aperture micro-tomograph to image simultaneously and from identical projection angles in vivo distributions of bioluminescent and (near-infrared) fluorescent molecular markers and radiolabeled pharmaceutical distributions. Unified data acquisition and reconstruction is the main motivation given the long ter......
#Bioluminescence #Fluorescence #Apertures #In vivo #Pharmaceuticals #Data acquisition #Image reconstruction #Protein engineering #Animals #Optical imaging
Locating molecules using optical microscopy: 3-D imaging by coherent antistokes Raman scattering
- Trang 781-784
Most microscopy methods do not directly reveal the chemical identity responsible for image formation. Fluorescence imaging, resulting from either intrinsic species or added dyes, is molecule specific but generally does not reveal bulk species. All chemical species have a characteristic Raman spectrum. We demonstrate a nonlinear microscopy method that provides a new solution to the problems of sign......
#Optical microscopy #Optical scattering #Optical imaging #Raman scattering #Fluorescence #Chemicals #Nonlinear optics #Production #Resonance #Photobleaching
Lossy-to-lossless ROI coding of chromosome images using modified SPIHT and EBCOT
- Trang 317-320
This paper proposes a lossy-to-lossless region of interest (ROI) compression scheme based on set partitioning in hierarchical trees (SPIHT) and embedded block coding with optimized truncation (EBCOT) (EBCOT is the base of the JPEG-2000 standard). However, SPIHT does not support ROI coding and JPEG-2000 does not allow lossy-to-lossless ROI compression. For our application, we modify the original SP......
#Image coding #Biological cells #Image storage #Wavelet domain #Biomedical imaging #Image segmentation #Medical diagnostic imaging #Space technology #Wavelet transforms #Performance loss
Automatic fiber tractography from DTI and its validation
- Trang 501-504
To understand evolving pathology in the central nervous system (CNS) and develop effective treatments, it is essential to correlate the nerve fiber connectivity with the visualization of function. Such information is fundamental in CNS processes since anatomical connections determine where information is passed and processed Diffusion tensor imaging (DTI) can provide the fundamental information re......
#Diffusion tensor imaging #Smoothing methods #Tensile stress #Visualization #Organisms #Nonlinear equations #Mathematics #Biochemistry #Neuroscience #Robustness
Automated cryo-electron microscopy
- Trang 741-744
Cryo-electron microscopy is widely viewed as a uniquely powerful method for the study of membrane proteins and large macromolecular complexes - subjects that are viewed as extremely challenging or impossible to study using x-ray or NMR methods. Although the methodology of molecular microscopy has enormous potential, it is time consuming and labor intensive. Our group has done extensive work to aut......
#Proteins #Electron microscopy #Image resolution #Image analysis #Assembly #Ice #Image reconstruction #Data analysis #Biomembranes #X-ray imaging
Three dimensional functional cartography of the human basal ganglia by registration of optical and histological serial sections
- Trang 329-332
In functional neurosurgery, there is a need for accurate localisation of the functional targets. One example is given by Parkinson's disease. The surgical intervention is based on the introduction of electrodes in the subthalamic nucleus. This nucleus is targeted on pre-operative stereotactic MR acquisitions. But MR imaging of the basal ganglia is intrinsically limited, first by image resolution, ......
#Humans #Basal ganglia #Optical imaging #Image reconstruction #Neurosurgery #Parkinson's disease #Surgery #Electrodes #Image resolution #Anatomy
3D reconstruction of 2D crystals from projections in real space
- Trang 689-692
A new algorithm for 3D reconstruction of two-dimensional crystals from projections is presented, and applied to biological macromolecules imaged using electron microscopy. Its main departure from the traditional approach is that it works in real space, rather than in Fourier space, and is iterative. This approach has the advantage of making it convenient to introduce additional constraints (such a......
#Crystals #Image reconstruction #Transmission electron microscopy #Crystallization #Lattices #Iterative methods #Electron microscopy #Fourier transforms #Iterative algorithms #Molecular biophysics