YKL-40 Protein Levels and Clinical Outcome of Human Endometrial Cancer

Journal of International Medical Research - Tập 38 Số 4 - Trang 1448-1457 - 2010
Cheng‐Liang Peng1, Jiayuan Peng1, Lan Jiang1, Qiang You1, Jianfeng Zheng1, Xi‐Jing Ning2
11 Department of Obstetrics and Gynaecology, The First Affiliated Hospital
22 Department of Pathology, The Tumour Hospital, Harbin Medical University, Harbin, China

Tóm tắt

The secreted glycoprotein YKL-40 is a member of the chitinase family and elevated serum YKL-40 levels have been reported to be associated with reduced survival in several malignancies, including endometrial cancer. This study investigated immunoreactivity to YKL-40 protein and its prognostic implications in endometrial cancer. Levels of YKL-40 protein in normal endometrium ( n = 42), endometrial hyperplasia ( n = 40) and endometrial adeno carcinoma ( n = 68) were examined using immunohistochemistry. YKL-40 immunoreactivity was significantly higher in endometrial adenocarcinoma compared with hyperplastic and normal endo metrium. In addition, high immuno reactivity of YKL-40 protein was associated with advanced stage, high histological grade, lymph node metastasis and lympho vascular invasion. Moreover, positive immunoreactivity for YKL-40 was a significant predictor of poor prognosis, as measured by estimated progression-free survival and estimated overall survival, compared with negative immunoreactivity. In conclusion, high YKL-40 immuno reactivity in endometrial cancer may be associated with poor prognosis.

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Journal of International Medical Research

Tập 38 Số 4

1448-1457

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