When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy

Springer Science and Business Media LLC - Tập 36 Số 10 - Trang 2103-2109 - 2019
Shelby A. Neal1, Lee Ryun Sun2, Chaim Jalas2, S.J. Morin3,4, T.A. Molinaro3, Richard T. Scott3
1IVI/RMA New Jersey, 140 Allen Rd, Basking Ridge, NJ, 07920, USA.
2Foundation for Embryonic Competence, Basking Ridge, USA
3IVI/RMA New Jersey, Basking Ridge, USA
4Sidney Kimmel College of Medicine, Thomas Jefferson University, Philadelphia, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Cimadomo D, Rienzi L, Romanelli V, Alviggi E, Levi-Setti PE, Albani E, et al. Inconclusive chromosomal assessment after blastocyst biopsy: prevalence, causative factors and outcomes after re-biopsy and re-vitrification. A multicenter experience. Hum Reprod Oxf Engl. 2018;33(10):1839–46.

Brower M, Hill D, Danzer H, Surrey M, Ghadir S, Chang W, et al. “No diagnosis” embryos after PGS should not be discarded: rebiopsy and reanalysis demonstrate the majority are euploid. Fertil Steril. 2014;102(3):e31.

Kaing A, Kroener L, Brower M, Hill D, Danzer H, Barritt J. Rebiopsy and preimplanation genetic screening (PGS) reanalysis demonstrate the majority of originally “no diagnosis” embryos are euploid with comparable pregnancy rates. Fertil Steril. 2015;104(3):e277.

Lee H, McCulloh DH, Olivares R, Goldstein-Tufaro A, McCaffrey C, Grifo J. Live births after transfer of rebiopsy and revitrification of blastocyst that had “no diagnosis” following trophectoderm biopsy. Fertil Steril. 2016;106(3):e164.

Neitzel D, Alouf CA, Robinson K, Zhu M, Faulkner N. Re-biopsied pgs embryos yield actionable results. Fertil Steril. 2017;108(3):e290.

Priner S, Altarescu G, Schonberger O, Holzer H, Rubinstein E, Dekel N, et al. The effect of repeated biopsy on pre-implantation genetic testing for monogenic diseases (PGT-M) treatment outcome. J Assist Reprod Genet. 2018.

Heitmann RJ, Hill MJ, Richter KS, DeCherney AH, Widra EA. The simplified SART embryo scoring system is highly correlated to implantation and live birth in single blastocyst transfers. J Assist Reprod Genet. 2013;30(4):563–7.

Zhang S, Tan K, Gong F, Gu Y, Tan Y, Lu C, et al. Blastocysts can be rebiopsied for preimplantation genetic diagnosis and screening. Fertil Steril. 2014;102(6):1641–5.

Swain JE, Schoolcraft WB, Katz-Jaffe M. Dual trophectoderm biopsy on the same blastocyst does not impair clinical outcomes. Fertil Steril. 2015;104(3):e186.

Bradley CK, Livingstone M, Traversa MV, McArthur SJ. Impact of multiple blastocyst biopsy and vitrification-warming procedures on pregnancy outcomes. Fertil Steril. 2017;108(6):999–1006.