Vinblastine-Induced Precipitation of Microtubule Protein

American Association for the Advancement of Science (AAAS) - Tập 165 Số 3892 - Trang 498-499 - 1969
Robert Marantz1, Martha Ventilla2, Michael L. Shelanski3
1Departments of Pathology and Pharmacology, Albert Einstein College of Medicine, Bronx., New York 10461
2Department of Chemistry, Columbia University, New York, and Department of Pathology (Neuropathology), Albert Einstein College of Medicine
3Department of Pathology (Neuropathology) , Albert Einstein College of Medicine

Tóm tắt

Vinblastine quantitatively precipitates a protein from supernatants obtained from high-speed centrifugation of homogenates of HeLa cells and of pig brain. This protein migrates as a single band on gel electrophoresis, has a mobility identical to that of purified microtubule protein, and—like microtubule protein—binds colchicine. The precipitation is partially inhibited by 0.9 percent NaCl.

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Tài liệu tham khảo

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 165 Số 3892

498-499

Thông tin tác giả