VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Nature - Tập 438 Số 7069 - Trang 820-827 - 2005
Rosandra N. Kaplan1, Rebecca D. Riba1, Stergios Zacharoulis1, Anna H. Bramley1, Loı̈c Vincent2, Carla Costa1, Daniel D. MacDonald1, David Jin2, Koji Shido2, Scott Kerns1, Zhenping Zhu3, Daniel J. Hicklin3, Yan Wu3, Jeffrey L. Port4, Nasser K. Altorki4, Elisa Port5, Davide Ruggero6, Sergey V. Shmelkov7, Kristian K. Jensen7, Shahin Rafii8, David Lyden7
1Department of Pediatrics and the Children's Blood Foundation Laboratories,
2Genetic Medicine,
3Imclone Systems Incorporated, New York, 10014, New York, USA
4Surgery, Weill Cornell Medical College of Cornell University, 1300 York Avenue,
5Surgery, Memorial Sloan-Kettering Cancer Center, 1233 York Avenue, New York, 10021, New York, USA
6Fox Chase Cancer Center, Pennsylvania, 19111, Philadelphia, USA
7Cell and Developmental Biology
8Howard Hughes Medical Institute

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Coussens, L., Tinkle, C., Hanahan, D. & Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481–490 (2000)

Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumour angiogenesis and growth. Nature Med. 7, 1194–1201 (2001)

Autiero, M., Luttun, A., Tjwa, M. & Carmeliet, P. Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders. J. Thromb. Haemost. 1, 1356–1370 (2003)

Neeson, P., Thurlow, P., Jamieson, G. & Bradley, C. Lymphocyte-facilitated tumour cell adhesion to endothelial cells: the role of high affinity leukocyte integrins. Pathology 35, 50–55 (2003)

Hattori, K. et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment. Nature Med. 8, 841–849 (2002)

Pollard, J. W. Tumour-educated macrophages promote tumour progression and metastasis. Nature Rev. Cancer 4, 71–78 (2004)

Hiratsuka, S. et al. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell 2, 289–300 (2002)

De Palma, M., Vinneri, M. A., Roca, C. & Naldini, L. Targeting exogenous genes to tumour angiogenesis by transplantation of genetically modified hematopoietic cells. Nature Med. 9, 789–795 (2003)

Burger, J., Spoo, A., Dwenger, A., Burger, M. & Behringer, D. CXCR4 chemokine receptors (CD184) and α4β1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis). Br. J. Haematol. 122, 579–589 (2003)

Scott, L., Priestly, G. & Papayannopoulou, T. Deletion of α4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol. Cell. Biol. 23, 9349–9360 (2003)

Jonjic, N. et al. Molecules involved in the adhesion and cytotoxicity of activated monocytes on endothelial cells. J. Immunol. 148, 2080–2083 (1992)

Heissig, B. et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109, 625–637 (2002)

Bergers, G. et al. Matrix Metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature Cell Biol. 2, 737–744 (2000)

Huhtala, P. et al. Cooperative signalling by α5β1 and α4β1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J. Cell Biol. 129, 867–879 (1995)

Yakubenko, V. P., Lobb, R. R., Plow, E. F. & Ugarova, T. P. Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon α4β1-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp. Cell Res. 260, 73–84 (2000)

Ruzinova, M. B. et al. Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumours. Cancer Cell 4, 277–289 (2003)

Lyden, D. et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 401, 670–677 (1999)

Ratajczak, M. Z. et al. Stem cell plasticity revisted: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells ‘hide out’ in the bone marrow. Leukemia 18, 29–40 (2004)

Lapidot, T. & Petit, I. Current understanding of stem cell mobilization: The roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines and stromal cells. Exp. Hematol. 30, 973–981 (2002)

Balkwill, F. The significance of cancer cell expression of the chemokine receptor CXCR4. Semin. Cancer Biol. 14, 171–179 (2004)

Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50–56 (2001)

Hynes, R. O. Metastatic potential: generic predisposition of the primary tumour or rare, metastatic variants—or both? Cell 113, 821–823 (2003)

Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E. & Hanahan, D. Benefits of targeting both pericytes and endothelial cells in the tumour vasculature with kinase inhibitors. J. Clin. Invest. 111, 1287–1295 (2003)

Fidler, I. The organ microenvironment and cancer metastasis. Differentiation 70, 498–505 (2002)

Duda, D. G. et al. Differential transplantability of tumour-associated stromal cells. Cancer Res. 64, 5920–5924 (2004)

Folkman, J. Role of angiogenesis in tumour growth and metastasis. Semin. Oncol. 29, 515–518 (2002)

Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860–867 (2002)

Borsig, L., Wong, R., Hynes, R. O., Varki, N. M. & Varki, A. Synergistic effects of L- and P-selectin in facilitating tumour metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc. Natl Acad. Sci. USA 99, 2193–2198 (2000)

Lin, E. Y., Ngyuen, A. V., Russell, R. G. & Pollard, J. W. Colony stimulating factor 1 promoted progression of mammary tumours to malignancy. J. Exp. Med. 193, 727–740 (2001)

Qian, F., Hanahan, D. & Weissman, I. L. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Proc. Natl Acad. Sci. USA 98, 3976–3981 (2002)

Schoppmann, S. et al. Tumour-associated macrophages express lymphatic endothelial growth factors and are related to peritumoural lymphangiogenesis. Am. J. Pathol. 161, 947–956 (2002)

Tam, P. P., Parameswaran, M., Kinder, S. J. & Weinberger, R. P. The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation. Development 124, 1631–1642 (1999)

Kessinger, A., Mann, S., Murphy, B. O., Jackson, J. D. & Sharp, J. G. Circulating factors may be responsible for murine strain-specific responses to mobilizing cytokines. Exp. Hematol. 29, 775–778 (2001)

Hashimoto, N., Jin, H., Liu, T., Chensue, S. W. & Phan, S. H. Bone marrow-derived progenitor cells in pulmonary fibrosis. J. Clin. Invest. 113, 243–252 (2004)

Jensen, K. K. et al. The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma. J. Immunol. 174, 3686–3694 (2005)

Huaux, F., Tianju, L., McGarry, B., Ullenbruch, M. & Phan, S. H. Dual roles of IL-4 in lung injury and fibrosis. J. Immunol. 170, 2083–2092