USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4

Translational Oncology - Tập 15 - Trang 101250 - 2022
Mi-Jeong Kim1, Bongkum Choi2, Ji Young Kim1, Yoon Min1, Do Hee Kwon1, Juhee Son1, Ji Su Lee1, Joo Sang Lee3, Eunyoung Chun4, Ki-Young Lee1,5
1Department of Immunology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea
2Department of Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
3Department of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea
4CHA Vaccine Institute, 560 Dunchon-daero, Jungwon-gu, Seongnam-si, Gyeonggi-do 13230, Republic of Korea
5Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea

Tài liệu tham khảo

Young, 2019, The role of ubiquitin-specific peptidases in cancer progression, J. Biomed. Sci., 26, 42, 10.1186/s12929-019-0522-0

Byun, 2013, USP8 is a novel target for overcoming gefitinib resistance in lung cancer, Clin. Cancer Res., 19, 3894, 10.1158/1078-0432.CCR-12-3696

Reyes-Turcu, 2009, Polyubiquitin binding and disassembly by deubiquitinating enzymes, Chem. Rev., 109, 1495, 10.1021/cr800470j

Swatek, 2016, Ubiquitin modifications, Cell Res., 26, 399, 10.1038/cr.2016.39

Yau, 2016, The increasing complexity of the ubiquitin code, Nat. Cell Biol., 18, 579, 10.1038/ncb3358

Lauwers, 2009, K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway, J. Cell Biol., 185, 493, 10.1083/jcb.200810114

Oh, 2014, USP8 modulates ubiquitination of LRIG1 for met degradation, Sci. Rep., 4, 4980, 10.1038/srep04980

Park, 2016, Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches, Cells, 5, 15, 10.3390/cells5020015

Xia, 2014, NF-kappaB, an active player in human cancers, Cancer Immunol. Res., 2, 823, 10.1158/2326-6066.CIR-14-0112

Bhutia, 2013, Autophagy: cancer's friend or foe?, Adv. Cancer. Res., 118, 61, 10.1016/B978-0-12-407173-5.00003-0

Zhan, 2014, Autophagy facilitates TLR4-and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination, Autophagy, 10, 257, 10.4161/auto.27162

Min, 2018, Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation, Autophagy, 14, 1347, 10.1080/15548627.2018.1474995

Kim, 2020, p62 is negatively implicated in the TRAF6-BECN1 signaling axis for autophagy activation and cancer progression by Toll-Like receptor 4 (TLR4), Cells, 9, 1142, 10.3390/cells9051142

Kim, 2019, CRBN is a negative regulator of bactericidal activity and autophagy activation through inhibiting the ubiquitination of ECSIT and BECN1, Front. Immunol., 10, 2203, 10.3389/fimmu.2019.02203

Kishida, 2005, TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway, Genes Cells, 10, 447, 10.1111/j.1365-2443.2005.00852.x

Chen, 2005, Ubiquitin signalling in the NF-kappaB pathway, Nat. Cell Biol., 7, 758, 10.1038/ncb0805-758

Morlon, 2005, TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd, Hum. Mol. Genet., 14, 3751, 10.1093/hmg/ddi405

Shi, 2010, TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy, Sci. Signal, 3, ra42, 10.1126/scisignal.2000751

Shi, 2010, Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1, Autophagy, 6, 986, 10.4161/auto.6.7.13288

Xu, 2016, USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1, Genes Dev., 30, 1718, 10.1101/gad.285122.116

Min, 2017, Ubiquitin-specific protease 14 negatively regulates toll-like receptor 4-mediated signaling and autophagy induction by inhibiting ubiquitination of TAK1-binding protein 2 and beclin 1, Front. Immunol., 8, 1827, 10.3389/fimmu.2017.01827

Kaur, 2019, Classification of early and late stage liver hepatocellular carcinoma patients from their genomics and epigenomics profiles, PLoS ONE, 14, 10.1371/journal.pone.0221476

Luedde, 2011, NF-κB in the liver—Linking injury, fibrosis and hepatocellular carcinoma, Nat. Rev. Gastroenterol. Hepatol., 8, 108, 10.1038/nrgastro.2010.213

Elsharkawy, 2007, Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis, Hepatology, 46, 590, 10.1002/hep.21802

Dai, 2015, Golgi phosphoprotein 3 (GOLPH3) promotes hepatocellular carcinoma cell aggressiveness by activating the NF-kappaB pathway, J. Pathol., 235, 490, 10.1002/path.4479

Yancopoulos, 2000, Vascular-specific growth factors and blood vessel formation, Nature, 407, 242, 10.1038/35025215

Moon, 2009, Sulforaphane suppresses TNF-α-mediated activation of NF-κB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3, Cancer Lett., 274, 132, 10.1016/j.canlet.2008.09.013

Shimizu, 2012, Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells, Life Sci., 90, 525, 10.1016/j.lfs.2012.01.013

Chao, 2020, Autophagy and liver cancer, Clin. Mol. Hepatol., 26, 606, 10.3350/cmh.2020.0169

Campbell, 2018, USP8 deubiquitinates SHANK3 to control synapse density and SHANK3 activity-dependent protein levels, J. Neurosci., 38, 5289, 10.1523/JNEUROSCI.3305-17.2018

Leem, 2020, 4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39+ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers, J. Immunother. Cancer, 8, 10.1136/jitc-2020-001650

Pertea, 2015, StringTie enables improved reconstruction of a transcriptome from RNA-seq reads, Nat. Biotechnol., 33, 290, 10.1038/nbt.3122

Pertea, 2016, Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown, Nat. Protoc., 11, 1650, 10.1038/nprot.2016.095

Kawai, 2007, 24

Peng, 2017, Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress, Cell Res., 27, 657, 10.1038/cr.2017.40

Peng, 2020, The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity, Autophagy, 16, 698, 10.1080/15548627.2019.1635381

Luo, 2016, PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression, Autophagy, 12, 1355, 10.1080/15548627.2015.1034405

Liu, 2018, Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy, Cancer Sci., 109, 3055, 10.1111/cas.13746

Ding, 2011, Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation, Clin. Cancer Res., 17, 6229, 10.1158/1078-0432.CCR-11-0816

Shi, 2011, Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis, Autophagy, 7, 1159, 10.4161/auto.7.10.16818

Okuda, 2012, Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem–like cells with macrophages and stromal cells, Cancer Res., 72, 537, 10.1158/0008-5472.CAN-11-1678

Yang, 2017, CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis, Oncol. Rep., 38, 1393, 10.3892/or.2017.5798

Ye, 2017, JCAD promotes progression of nonalcoholic steatohepatitis to liver cancer by inhibiting LATS2 kinase activity, Cancer Res., 77, 5287, 10.1158/0008-5472.CAN-17-0229

Ni, 2015, Serum amyloid A is a novel prognostic biomarker in hepatocellular carcinoma, Asian Pac. J. Cancer Prev., 15, 10713, 10.7314/APJCP.2014.15.24.10713

Li, 2011, Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis, PLoS ONE, 6, e28133, 10.1371/journal.pone.0028133

Lian, 2016, PRL-3 promotes cell adhesion by interacting with JAM2 in colon cancer, Oncol. Lett., 12, 1661, 10.3892/ol.2016.4836

Chen, 2013, Expression of FOXJ1 in hepatocellular carcinoma: correlation with patients' prognosis and tumor cell proliferation, Mol. Carcinog., 52, 647, 10.1002/mc.21904

Famili, 2015, Discrete roles of canonical and non-canonical Wnt signaling in hematopoiesis and lymphopoiesis, Cell Death Dis., 6, e1981, 10.1038/cddis.2015.326

Wilkinson, 2000, 141

Dawson, 2008, Hepatocellular carcinoma and the ubiquitin–proteasome system, Biochim. Biophys. Acta BBA Mol. Basis Dis., 1782, 775, 10.1016/j.bbadis.2008.08.003

Ni, 2017, Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion, Acta Biochim. Biophys. Sin., 49, 680, 10.1093/abbs/gmx056

Zhang, 2018, Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma, Lab. Investig., 98, 883, 10.1038/s41374-018-0050-7

Wang, 2015, Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma, J. Transl. Med., 13, 1, 10.1186/s12967-015-0396-1

Tang, 2015, Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma, Int. J. Oncol., 47, 2208, 10.3892/ijo.2015.3214