Role of the autophagy-related marker LC3 expression in hepatocellular carcinoma: a meta-analysis
Tóm tắt
Microtubule-associated protein 1 light chain 3 (LC3), an autophagic gene, has been reported as a vital marker for many diseases and cancers. However, the role of LC3 in hepatocellular carcinoma (HCC) was not still investigated. Therefore, we conducted a meta-analysis to examine the association of LC3 with its clinicopathological and prognostic in HCC. We consulted the PubMed, Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure and Wan Fang databases for published studies on LC3 in HCC. Newcastle–Ottawa scale was used to screen the quality of the literature. The statistical analysis was calculated by STATA 14.2. Of the 1329 titles identified, 10 articles involving 949 patients in HCC were included in this meta-analysis. The results of our study show that increased LC3 expression is related to size of tumor, but not to gender, age, number of tumor, liver cirrhosis, HBsAg, TNM stage, alpha fetoprotein, vascular invasion and histological grade. Positive LC3 expression was associated with overall survival by pooled hazard ratio. This meta-analysis indicated that positive LC3 expression was related to size of tumor, and could predict prognosis in human hepatocellular carcinoma.
Tài liệu tham khảo
Bao L, Chandra PK, Moroz K et al (2014) Impaired autophagy response in human hepatocellular carcinoma. Exp Mol Pathol 96:149–154
Boyvat F (2017) Interventional radiologic treatment of hepatocellular carcinoma. Exp Clin Transplant 15(suppl 2):25–30
Chih WL, Chih CH, Lee PH et al (2017) The autophagy marker LC3 strongly predicts immediate mortality after surgical resection for hepatocellular carcinoma. Oncotarget 8:91902–91913
Choi AM, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368:651–662
Ding ZB, Shi YH, Zhou J et al (2008) Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 68:9167–9175
Galais M, Pradel B, Vergne I et al (2019) LAP (LC3-associated phagocytosis): phagocytosis or autophagy? Med Sci (Paris) 35:635–642
Ghavami S, Shojaei S, Yeganeh B et al (2014) Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog Neurobiol 112:24–49
Gingold JA, Zhu D, Lee DF et al (2018) Genomic profiling and metabolic homeostasis in primary liver cancers. Trends Mol Med 24:395–411
Grandhi MS, Kim AK, Ronnekleiv-Kelly SM et al (2016) Hepatocellular carcinoma: from diagnosis to treatment. Surg Oncol 25:74–85
Han Y, Xue XF, Shen HG et al (2014) Prognostic significance of Beclin-1 expression in colorectal cancer: a meta-analysis. Asian Pac J Cancer Prev 15:4583–4587
Hartke J, Johnson M, Ghabril M (2017) The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol 34:153–159
Jiang X, Bao Y, Liu H et al (2017) VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene 36:6850–6862
Lee YJ, Jang BK (2015) The role of autophagy in hepatocellular carcinoma. Int J Mol Sci 16:26629–26643
Lee Y, Hah YJ, Kang YN et al (2013) The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma. PLoS ONE 8:e81540
Li F, Xu P, Gao TT et al (2018) Expression and significance of autophagy related protein Beclin1, LC3, and mTOR in hepatic carcinoma. Chin J Gerontol 8:3890–3892
Liang CJ, Ge H, Zhang KT et al (2018) Role of beclin1 expression in patients with hepatocellular carcinoma: a meta-analysis. OncoTargets Ther 4:2387–2397
Lu YD (2012) Expression and significance of autophagy related protein LC3. MA thesis. Taiyuan: Shanxi medical University, China
Lv C, Zhang Z, Zhao T et al (2019) The anti-tumour effect of Mel and its role in autophagy in human hepatocellular carcinoma cells. Am J Transl Res 11:931–941
Maruyama Y, Sou S, Kageyam S et al (2014) LC3B is indispensable for selective autophagy of p62 but not basal autophagy. Biochem Biophys Res Commun 446:309–315
Morselli E, Galluzzi L, Kepp O et al (2009) Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta 1793:1524–1532
Segala G, David M, de Medina P et al (2017) Dendrogenin A drives LXR to trigger lethal autophagy in cancers. Nat Commun 8:1903
Shen Y, Liang LZ, Hong MH et al (2008) Expression and clinical significance of microtubule-associated protein 1 light chain 3 (LC3) and Beclin1 in epithelial ovarian cancer. Ai Zheng 27:595–599
Song MQ, Xue YK, Sun YX et al (2014) Expression and clinical significance of mammalian target of rapamycin and microtubules-associated protein 1 light chain 3-β in hepatocellular carcinama. Chin J Exp Surg 31:1108–1110
Wu DH, Jia CC, Chen J et al (2014a) Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma. Tumor Biol 35:12225–12233
Wu WY, Kim H, Zhang CL et al (2014b) Clinical signification of autophagic protein LC3 levels and its correlation with XIAP expression in hepatocellular carcinoma. Med Oncol 31:108
Wu S, Sun C, Tian D et al (2015) Expression and clinical significances of Beclin1, LC3 and mTOR in colorectal cancer. Int J Clin Exp Pathol 8:3882–3891
Wu WY, Meng XL, Qi Y et al (2016) Clinical significance of LC3B and p62 expression in human hepatocellular carcinoma. J Clin Exp Pathol 32:366–369
Wu DH, Wang TT, Ruan DY et al (2018) Combination of ULK1 and LC3B improve prognosis assessment of hepatocellular carcinoma. Biomed Pharmacother 97:195–202
Xi SY, Lu JB, Chen JW et al (2013) The “stone-like” pattern of LC3A expression and its clinicopathologic significance in hepatocellular carcinoma. Biochem Biophys Res Commun 431:760–766
Yao LL, Zhou YD, Sui AH et al (2019) HBV-encoded miR-2 functions as an oncogene by downregulating TRIM35 but upregulating RAN in liver cancer cells. EBioMedicine 09:1–13
Yu H, Liu QH, Xiao PL et al (2018) Expression and clinical significance of Beclin1, LC3, and mTOR in hepatic carcinoma. Anhui Med Pharm J 22:246–249
Zhang S, Li J, Zhou G et al (2017) Aurora-A regulates autophagy through the Akt pathway in human prostate cancer. Cancer Biomark 19:27–34
Zhao YT, Pang ZG, Ma DM et al (2016) Expression of forkhead transcription factor group O1 and autophagy related protein microtubule associated protein 1 light chain 3-II in hepatocellular carcinama and significance. Chin J Exp Surg 33:492–494
Zhao Z, Xue J, Zhao X et al (2017) Prognostic role of autophagy-related proteins in epithelial ovarian cancer: a meta-analysis of observational studies. Minerva Med 108:277–286