Tumor invasion and metastasis in Drosophila: A bold past, a bright future

Adams, 2000, The genome sequence of Drosophila melanogaster, Science, 287, 2185, 10.1126/science.287.5461.2185

Albini, 2007, The tumour microenvironment as a target for chemoprevention, Nat. Rev. Cancer, 7, 139, 10.1038/nrc2067

Beaucher, 2007, Metastatic ability of Drosophila tumors depends on MMP activity, Dev. Biol., 303, 625, 10.1016/j.ydbio.2006.12.001

Beaucher, 2007, Drosophila brain tumor metastases express both neuronal and glial cell type markers, Dev. Biol., 301, 287, 10.1016/j.ydbio.2006.09.019

Bernards, 2002, Metastasis genes: a progression puzzle, Nature, 418, 823, 10.1038/418823a

Bilder, 2000, Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors, Science, 289, 113, 10.1126/science.289.5476.113

Brumby, 2003, scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila, EMBO J., 22, 5769, 10.1093/emboj/cdg548

Brumby, 2011, Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-Family/JNK pathway is a central driver of tumorigenesis, Genetics, 188, 105, 10.1534/genetics.111.127910

Chan, 2000, Drosophila models of human neurodegenerative disease, Cell Death Differ., 7, 1075, 10.1038/sj.cdd.4400757

Charroux, 2010, Drosophila immune response: from systemic antimicrobial peptide production in fat body cells to local defense in the intestinal tract, Fly, 4, 40, 10.4161/fly.4.1.10810

Cordero, 2009, APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates, Cell Cycle, 8, 2926, 10.4161/cc.8.18.9472

Cordero, 2011, Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia, Acta Physiol, 10.1111/j.1748-1716.2011.02288.x

Cordero, 2010, Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter, Dev. Cell, 18, 999, 10.1016/j.devcel.2010.05.014

Dang, 1992, Use of a yeast site-specific recombinase to generate embryonic mosaics in Drosophila, Dev. Genet., 13, 367, 10.1002/dvg.1020130507

Edwards, 2011, Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells, Dis. Model Mech., 4, 496, 10.1242/dmm.006486

Ferres-Marco, 2006, Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing, Nature, 439, 430, 10.1038/nature04376

Gateff, 1978, Malignant neoplasms of genetic origin in Drosophila melanogaster, Science, 200, 1448, 10.1126/science.96525

Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013

Hogan, 2009, Characterization of the interface between normal and transformed epithelial cells, Nat. Cell Biol., 11, 460, 10.1038/ncb1853

Huang, 2005, The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP, Cell, 122, 421, 10.1016/j.cell.2005.06.007

Huang, 2003, Targeting mTOR signaling for cancer therapy, Curr. Opin. Pharmacol., 3, 371, 10.1016/S1471-4892(03)00071-7

Humbert, 2008, Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module, Oncogene, 27, 6888, 10.1038/onc.2008.341

Igaki, 2009, Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila, Dev. Cell, 16, 458, 10.1016/j.devcel.2009.01.002

Jiang, 2009, Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut, Cell, 137, 1343, 10.1016/j.cell.2009.05.014

Kajita, 2010, Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells, J. Cell Sci., 123, 171, 10.1242/jcs.057976

Lee, 2001, Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development, Trends Neurosci., 24, 251, 10.1016/S0166-2236(00)01791-4

Lee, 2009, Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation, Development, 136, 2255, 10.1242/dev.035196

McCarthy, 2009, Cancer genetics: networking on the fly, Nat. Rev. Genet., 10, 150, 10.1038/nrg2551

McClure, 2008, Three genes control the timing, the site and the size of blastema formation in Drosophila, Dev. Biol., 319, 68, 10.1016/j.ydbio.2008.04.004

Mechler, 1985, Molecular cloning of lethal(2) giant larvae, a recessive oncogene of Drosophila melanogaster, EMBO J., 4, 1551, 10.1002/j.1460-2075.1985.tb03816.x

Micchelli, 2006, Evidence that stem cells reside in the adult Drosophila midgut epithelium, Nature, 439, 475, 10.1038/nature04371

Montell, 2003, Border-cell migration: the race is on, Nat. Rev. Mol. Cell Biol., 4, 13, 10.1038/nrm1006

Moreno, 2002, Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development, Nature, 416, 755, 10.1038/416755a

Nguyen, 2007, Genetic determinants of cancer metastasis, Nat. Rev. Genet., 8, 341, 10.1038/nrg2101

Ohlstein, 2006, The adult Drosophila posterior midgut is maintained by pluripotent stem cells, Nature, 439, 470, 10.1038/nature04333

Ohsawa, 2011, Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila, Dev. Cell, 20, 315, 10.1016/j.devcel.2011.02.007

Pagliarini, 2003, A genetic screen in Drosophila for metastatic behavior, Science, 302, 1227, 10.1126/science.1088474

Parisi, 2011, Epithelial delamination and migration: lessons from Drosophila, Cell Adh. Migr., 5, 366, 10.4161/cam.5.4.17524

Podsypanina, 2008, Seeding and propagation of untransformed mouse mammary cells in the lung, Science, 321, 1841, 10.1126/science.1161621

Raftery, 1999, TGF-beta family signal transduction in Drosophila development: from Mad to Smads, Dev. Biol., 210, 251, 10.1006/dbio.1999.9282

Harshbarger, 1968, Neoplasms of insects, Annu. Rev. Entomol., 13, 159, 10.1146/annurev.en.13.010168.001111

Ryoo, 2004, Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways, Dev. Cell, 7, 491, 10.1016/j.devcel.2004.08.019

Schafer, 2008, Cancer as an overhealing wound: an old hypothesis revisited, Nat. Rev. Mol. Cell Biol., 9, 628, 10.1038/nrm2455

Schneider, 2000, Using Drosophila as a model insect, Nat. Rev. Genet., 1, 218, 10.1038/35042080

St John, 1997, Understanding human cancer in a fly?, Am. J. Hum. Genet., 61, 1006, 10.1086/301619

Stefanatos, 2011, Mitochondrial complex I: a central regulator of the aging process, Cell Cycle, 10, 1528, 10.4161/cc.10.10.15496

Theodosiou, 1998, Use of FLP/FRT system to study Drosophila development, Methods, 14, 355, 10.1006/meth.1998.0591

Toba, 1999, The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster, Genetics, 151, 725, 10.1093/genetics/151.2.725

Valanne, 2011, The Drosophila Toll signaling pathway, J. Immunol., 186, 649, 10.4049/jimmunol.1002302

Vallejo, 2011, Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells, EMBO J., 30, 756, 10.1038/emboj.2010.358

Vidal, 2006, Drosophila models for cancer research, Curr. Opin. Genet. Dev., 16, 10, 10.1016/j.gde.2005.12.004

Vidal, 2006, Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis, Dev. Cell, 10, 33, 10.1016/j.devcel.2005.11.007

Willecke, 2011, Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model, Oncogene, 10.1038/onc.2011.125

Woodhouse, 1998, Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes, Dev. Genes Evol., 207, 542, 10.1007/s004270050145

Woodhouse, 1994, Increased type IV collagenase in lgl-induced invasive tumors of Drosophila, Cell Growth Differ., 5, 151

Woodhouse, 2003, Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype, Proc. Natl. Acad. Sci. USA, 100, 11463, 10.1073/pnas.2031202100

Wu, 2010, Interaction between RasV12 and scribbled clones induces tumour growth and invasion, Nature, 463, 545, 10.1038/nature08702

Yoshida, 2004, Lessons from border cell migration in the Drosophila ovary: a role for myosin VI in dissemination of human ovarian cancer, Proc. Natl. Acad. Sci. USA, 101, 8144, 10.1073/pnas.0400400101