Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids

American Association for the Advancement of Science (AAAS) - Tập 227 Số 4693 - Trang 1485-1487 - 1985
Alan H. Fairlamb1, Peter Blackburn1, Peter Ulrich1, Brian T. Chait1, Bruce Beutler1
1Rockefeller University, New York 10021.

Tóm tắt

Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-spermidine conjugate, N 1 ,N 8 -bis(L-γ-glutamyl-L-hemicystinyl-glycyl)spermidine, for which the trivial name trypanothione is proposed. This discovery may open a new chemotherapeutic approach to trypanosomiasis and leishmaniasis.

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American Association for the Advancement of Science (AAAS)

Tập 227 Số 4693

1485-1487

Thông tin tác giả