Trimethoprim and Sulfamethoxazole are Selective Inhibitors of CYP2C8 and CYP2C9, Respectively

Back, 1988, In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines., Br J Clin Pharmacol, 26, 23, 10.1111/j.1365-2125.1988.tb03359.x

Craig, 1973, Distribution of trimethoprim-sulfamethoxazole in tissues of rhesus monkeys., J Infect Dis, 128 (Suppl), 575, 10.1093/infdis/128.Supplement_3.S575

Cribb, 1995, N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes., Drug Metab Dispos, 23, 406

Dierks, 2001, A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry., Drug Metab Dispos, 29, 23

Dollery C (1999) Sulfamethoxazole and trimethoprim combination. in Therapeutic Drugs, ed Dollery C (Churchill Livingstone, Edinburgh), pp S136–S140.

Edwards, 1990, Lack of effect of co-trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine., Br J Clin Pharmacol, 30, 889, 10.1111/j.1365-2125.1990.tb05456.x

Gleckman, 1981, Trimethoprim: mechanisms of action, antimicrobial activity, bacterial resistance, pharmacokinetics, adverse reactions, and therapeutic indications., Pharmacotherapy, 1, 14, 10.1002/j.1875-9114.1981.tb03548.x

Hansen, 1979, The effect of different sulfonamides on phenytoin metabolism in man., Acta Med Scand Suppl, 624, 106, 10.1111/j.0954-6820.1979.tb00729.x

Harris, 1994, Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme., Cancer Res, 54, 4026

Johnson, 1990, Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction., DICP-Ann Pharmacother, 24, 250

10.1002/jps.2600741019

Komatsu, 2000, Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments., Drug Metab Dispos, 28, 475

Komatsu, 2000, Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4., Drug Metab Dispos, 28, 1361

10.1021/bi961950t

10.1016/S0009-9236(96)90183-6

Ohyama, 2000, A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor., Drug Metab Dispos, 28, 1303

10.1046/j.1365-2125.2000.00316.x

O'Reilly, 1980, Stereoselective interaction of trimethoprim-sulfamethoxazole with the separated enantiomorphs of racemic warfarin in man., N Engl J Med, 302, 33, 10.1056/NEJM198001033020106

Rieder, 1975, Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons., Arzneim-Forsch, 25, 656

Segel RH (1975) Simple inhibition system. in Enzyme Kinetics, ed Segel IH (John Wiley & Sons, New York), pp 100–160.

Stewart, 1986, High-performance liquid chromatography with electrochemical detection of chlorzoxazone and its hydroxy metabolite in serum using solid-phase extraction., J Chromatogr, 380, 177, 10.1016/S0378-4347(00)83640-3

10.1016/S0006-2952(97)00239-6

Wang, 2000, Human cytochrome P-450 3A4 in vitro drug-drug interaction patterns are substrate-dependent., Drug Metab Dispos, 28, 360

10.1046/j.0306-5251.2001.01474.x

Wing, 1985, Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition., Br J Clin Pharmacol, 20, 482, 10.1111/j.1365-2125.1985.tb05102.x