Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in abetalipoproteinemia.

Borchardt, 1987, Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion, J. Biol. Chem., 262, 16394, 10.1016/S0021-9258(18)49269-1

Davis, 1991, Lipoprotein structure and secretion, In Biochemistry of Lipids and Membranes. D. E. Vance and J. E. Vance, editors. Elsevier, Amsterdam, London, New York, Tokyo., 403

Dixon, 1993, Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells, J. Lipid Res., 34, 167, 10.1016/S0022-2275(20)40744-8

Bjornsson, 1994, Regulation of VLDL secretion in primary culture of rat hepatocytes, Eur. J. Clin. Invest., 24, 137, 10.1111/j.1365-2362.1994.tb00979.x

Adeli, 1994, Regulated degradation of apolipoprotein B in semipermeable HepG2 cells, J. Biol. Chem., 269, 9166, 10.1016/S0021-9258(17)37090-4

Davis, 1990, Apolipoprotein B is both integrated into and translocated across the endoplasmic reticulum membrane. Evidence for two functionally distinct pools, J. Biol. Chem., 265, 10005, 10.1016/S0021-9258(19)38770-8

Wilkinson, 1992, Determination of the intracellular distribution and pool sizes of apolipoprotein B in rabbit liver, Biochem. J., 288, 413, 10.1042/bj2880413

Dixon, 1992, Biosynthesis of lipoprotein: location of nascent apoA-I and apoB in the rough endoplasmic reticulum of chicken hepatocytes, J. Cell Biol., 117, 1161, 10.1083/jcb.117.6.1161

Rusinol, 1993, Movement of apolipoprotein B into the lumen of microsomes from hepatocytes is disrupted in membranes enriched in phosphatidylmonomethylethanolamine, J. Biol. Chem., 268, 25168, 10.1016/S0021-9258(19)74584-0

Sakata, 1993, Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in HepG2 cells, J. Biol. Chem., 268, 22967, 10.1016/S0021-9258(19)49411-8

Bonnardel, 1995, In HepG2 Cells, translocation, not degradation, determines the fate of the de novo synthesized apolipoprotein B., J. Biol. Chem., 270, 28892, 10.1074/jbc.270.48.28892

Thrift, 1992, Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a non-hepatic cell line, Proc. Natl. Acad. Sci. USA., 89, 9161, 10.1073/pnas.89.19.9161

Du, 1994, Proteolysis-coupled secretion of the N-termi-nus of apolipoprotein B: characterization of a transient, translocation-arrested intermediate, J. Biol. Chem., 269, 24169, 10.1016/S0021-9258(19)51064-X

Pullinger, 1989, The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life, J. Lipid Res., 30, 1065, 10.1016/S0022-2275(20)38287-0

Leighton, 1990, Fasting decreases apolipoprotein B mRNA editing and the secretion of small molecular weight apoB by rat hepatocytes: evidence that the total amount of apoB secreted is regulated post-transcriptionally, J. Lipid Res., 31, 1663, 10.1016/S0022-2275(20)42350-8

Davidson, 1988, Apolipoprotein gene expression in the rat is regulated in a tissue-specific manner by thyroid hormone, J. Lipid Res., 29, 1511, 10.1016/S0022-2275(20)38422-4

Gregg, 1994, The molecular basis of abetalipoproteinemia, Curr. Opin. Lipidol., 5, 81, 10.1097/00041433-199404000-00003

Shoulders, 1993, Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein, Hum. Molec. Genet., 2, 2109, 10.1093/hmg/2.12.2109

Sharp, 1993, Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinemia, Nature., 365, 65, 10.1038/365065a0

Kane, 1989, Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins, In The Metabolic Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, editors. McGraw-Hill, New York., 1139

Gordon, 1994, Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability, Proc. Natl. Acad. Sci. USA., 91, 7628, 10.1073/pnas.91.16.7628

Leiper, 1994, Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells, J. Biol. Chem., 269, 21951, 10.1016/S0021-9258(17)31740-4

Marcel, 1987, Mapping of human apolipoprotein B antigenic determinants, Arteriosclerosis., 7, 166, 10.1161/01.ATV.7.2.166

Menzel, 1990, Abetalipoproteinemia with an ApoB-100-lipoproteinfa] glycoprotein complex in plasma, Indication for an assembly defect. J. Biol. Chem., 265, 981

Gordon, 1995, The microsomal triglyceride transfer protein mediates both translocation of apolipoprotein B into the endoplasmic reticulum and the addition of core lipid in the formation of apolipoprotein B-100 very low density lipoprotein, Circulation., 92, 1

Yao, 1991, Expression of carboxyl-terminally truncated forms of human apolipoprotein B in rat hepatoma cells. Evidence that the length of apolipoprotein B has a major effect on the buoyant density of the secreted lipoproteins, J. Biol. Chem., 266, 3300, 10.1016/S0021-9258(18)49988-7

Dullaart, 1986, Epitopes of apolipoprotein B-100 and B-48 in both liver and intestine. Expression and evidence for local synthesis in recessive abetalipoproteinemia, J. Clin. Invest., 78, 1397, 10.1172/JCI112727

Lackner, 1986, Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia, J. Clin. Invest., 78, 1707, 10.1172/JCI112766

Bouma, 1990, Description of two different patients with abetalipoproteinemia: synthesis of a normal-sized apolipoprotein B-48 in intestinal organ culture, J. Lipid Res., 31, 1, 10.1016/S0022-2275(20)42755-5

Glickman, 1991, Apolipoprotein synthesis in normal and abetalipoproteinemie intestinal mucosa, Gastroenterology., 101, 749, 10.1016/0016-5085(91)90535-S

Black, 1991, Intestinal and hepatic apolipoprotein B gene expression in abetalipoproteinemia, Gastroenterology., 101, 520, 10.1016/0016-5085(91)90033-H

Nguyen, 1991, Binding protein BiP is required for translocation of secretory proteins into the endoplasmic reticulum, Proc. Natl. Acad. Sci. USA., 88, 1565, 10.1073/pnas.88.4.1565

Sanders, 1992, Sec61p and BiP directly facilitate polypeptide translocation into the ER, Cell., 69, 353, 10.1016/0092-8674(92)90415-9

Segrest, 1994, ApoB-100 has a pentapartite structure composed of three amphipathic alpha-helical domains alternating with two amphipathic beta-strand domains.Detection by the computer program LOCATE, Arterioscler. Thromb., 14, 1674, 10.1161/01.ATV.14.10.1674

Chuck, 1990, New variation on the translocation of proteins during early biogenesis of apolipoprotein B., Nature., 346, 382, 10.1038/346382a0

Young, 1986, Monoclonal antibody MB19 detects genetic polymorphism in human apolipoprotein B., Proc. Natl. Acad. Sci., 83, 1101, 10.1073/pnas.83.4.1101

Innerarity, 1987, Structural relationship of human apolipoprotein B-48 to apolipoprotein B-100, J. Clin. Invest., 80, 1794, 10.1172/JCI113273

Curtiss, 1982, Immunochemical heterogeneity of human plasma apolipoprotein B. I. Apolipoprotein B binding of mouse hybridoma antibodies, J. Biol. Chem., 257, 15213, 10.1016/S0021-9258(18)33415-X

Young, 1986, Conservation of the low density lipoprotein receptor-binding domain of apoprotein B. Demonstration by a new monoclonal antibody, MB47, Arteriosclerosis., 6, 178, 10.1161/01.ATV.6.2.178