Transformation of atenolol, metoprolol, and carbamazepine in soils: The identification, quantification, and stability of the transformation products and further implications for the environment

Abarzúa-Araya, 2014, Atenolol versus propranolol for the treatment of infantile hemangiomas: a randomized controlled study, J. Am. Acad. Dermatol, 70, 1045, 10.1016/j.jaad.2014.01.905

Abramovic, 2011, Photocatalytic degradation of metoprolol tartrate in suspensions of two TiO2-based photocatalysts with different surface area. Identification of intermediates and proposal of degradation pathways, J. Hazard. Mater, 198, 123, 10.1016/j.jhazmat.2011.10.017

Almeida, 2014, Presence of the pharmaceutical drug carbamazepine in coastal systems: effects on bivalves, Aquat. Toxicol., 156, 74, 10.1016/j.aquatox.2014.08.002

Brodin, 2013, Dilute concentrations of a psychiatric drug alter behavior of fish from natural populations, Science, 339, 814, 10.1126/science.1226850

Calza, 2013, Fate of selected pharmaceuticals in river waters, Environ. Sci. Pollut. R., 20, 2262, 10.1007/s11356-012-1097-4

Carballa, 2008, Determination of the solid–water distribution coefficient (Kd) for pharmaceuticals, estrogens and musk fragrances in digested sludge, Water Res., 42, 287, 10.1016/j.watres.2007.07.012

Chen, 2012, Photodegradation of selected beta-blockers in aqueous fulvic acid solutions: kinetics, mechanism, and product analysis, Water Res., 46, 2965, 10.1016/j.watres.2012.03.025

Collado, 2014, Pharmaceuticals occurrence in a WWTP with significant industrial contribution and its input into the river system, Environ. Pollut., 185, 202, 10.1016/j.envpol.2013.10.040

Contardo-Jara, 2010, The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environ, Pollut, 158, 2059, 10.1016/j.envpol.2010.03.012

Fedorova, 2013, Comparison of the quantitative performance of a Q-Exactive high-resolution mass spectrometer with that of a triple quadrupole tandem mass spectrometer for the analysis of illicit drugs in wastewater, Rapid Commun. Mass Sp., 27, 1751, 10.1002/rcm.6628

Gao, 1997, Preliminary study of the effects of metoprolol and propafenone on ventricular arrhythmia with positive ventricular late potential, Chin. Med. J.-Peking, 110, 723

Goldstein, 2001, Metoprolol controlled release/extended release in patients with severe heart failure - analysis of the experience in the MERIT-HF study, J. Am. Coll. Cardiol., 38, 932, 10.1016/S0735-1097(01)01516-9

Golovko, 2014, Removal and seasonal variability of selected analgesics/anti-inflammatory, anti-hypertensive/cardiovascular pharmaceuticals and UV filters in wastewater treatment plant, Environ. Sci. Pollut. R., 21, 7578, 10.1007/s11356-014-2654-9

Golovko, 2014, Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant, Chemosphere, 111, 418, 10.1016/j.chemosphere.2014.03.132

Golovko, 2016, Development of fast and robust multiresidual LC-MS/MS method for determination of pharmaceuticals in soils, Environ. Sci. Pollut. R., 1

Grabicova, 2015, Presence of pharmaceuticals in benthic fauna living in a small stream affected by effluent from a municipal sewage treatment plant, Water Res., 72, 145, 10.1016/j.watres.2014.09.018

Grossberger, 2014, Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater, Environ. Pollut., 185, 168, 10.1016/j.envpol.2013.10.038

Helbling, 2010, High-throughput identification of microbial transformation products of organic micropollutants, Environ. Sci. Technol., 44, 6621, 10.1021/es100970m

Horsing, 2011, Determination of sorption of seventy-five pharmaceuticals in sewage sludge, Water Res., 45, 4470, 10.1016/j.watres.2011.05.033

Kasprzyk-Hordern, 2009, The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters, Water Res., 43, 363, 10.1016/j.watres.2008.10.047

Kim, 2007, Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea, Environ. Int., 33, 370, 10.1016/j.envint.2006.11.017

Kodesova, 2015, Pharmaceuticals' sorptions relative to properties of thirteen different soils, Sci. Total Environ., 511, 435, 10.1016/j.scitotenv.2014.12.088

Kodešová, 2016, An analysis of the dissipation of pharmaceuticals under thirteen different soil conditions, Sci. Total Environ., 544, 369, 10.1016/j.scitotenv.2015.11.085

Lamichhane, 2013, Chronic effects of carbamazepine on life-history strategies of Ceriodaphnia dubia in three successive generations, Arch. Environ. Con. Tox., 64, 427, 10.1007/s00244-012-9845-5

Leucht, 2002, Carbamazepine augmentation for schizophrenia: how good is the evidence?, J. Clin. Psychiat, 63, 218, 10.4088/JCP.v63n0308

Li, 2014, Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil, Environ. Pollut., 187, 193, 10.1016/j.envpol.2014.01.015

Li, 2013, Degradation kinetics and metabolites of carbamazepine in soil, Environ. Sci. Technol., 47, 3678, 10.1021/es304944c

Maurer, 2007, Elimination of beta-blockers in sewage treatment plants, Water Res., 41, 1614, 10.1016/j.watres.2007.01.004

Monteiro, 2009, Factors affecting the degradation of pharmaceuticals in agricultural soils, Environ. Toxicol. Chem., 28, 2546, 10.1897/08-657.1

Neamtu, 2014, Degradation of eight relevant micropollutants in different water matrices by neutral photo-Fenton process under UV254 and simulated solar light irradiation - a comparative study, Appl. Catal. B-Environ, 158, 30, 10.1016/j.apcatb.2014.04.001

Paltiel, 2016, Human exposure to wastewater-derived pharmaceuticals in fresh produce: a randomized controlled trial focusing on carbamazepine, Environ. Sci. Technol., 7, 7

Poulsen, 2013, Effects of fertilization with urban and agricultural organic wastes in a field trial - waste imprint on soil microbial activity, Soil Biol. Biochem., 57, 794, 10.1016/j.soilbio.2012.02.031

Rey, 2012, Simulated solar-light assisted photocatalytic ozonation of metoprolol over titania-coated magnetic activated carbon, Appl. Catal. B-Environ, 111, 246, 10.1016/j.apcatb.2011.10.005

Rubirola, 2014, Characterization of metoprolol biodegradation and its transformation products generated in activated sludge batch experiments and in full scale WWTPs, Water Res., 63, 21, 10.1016/j.watres.2014.05.031

Salgado, 2013, Photodegradation kinetics and transformation products of ketoprofen, diclofenac and atenolol in pure water and treated wastewater, J. Hazard. Mater, 244–245, 516, 10.1016/j.jhazmat.2012.10.039

Salvia, 2014, Fate of pharmaceutical compounds and steroid hormones in soil: study of transfer and degradation in soil columns, Environ. Sci. Pollut. R., 21, 10525, 10.1007/s11356-014-3038-x

Sathyamoorthy, 2013, Biodegradation and cometabolic modeling of selected beta blockers during ammonia oxidation, Environ. Sci. Technol., 47, 12835, 10.1021/es402878e

Shakespeare, 1998, Economic analysis of epilepsy treatment: a cost minimization analysis comparing carbamazepine and lamotrigine in the UK, Seizure-Eur. J. Epilep, 7, 119, 10.1016/S1059-1311(98)80067-8

Shu, 2013, Photodegradation of emerging micropollutants using the medium-pressure UV/H2O2 Advanced Oxidation Process, Water Res., 47, 2881, 10.1016/j.watres.2013.02.045

Steinbach, 2014, The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss), Sci. Total Environ., 498, 209, 10.1016/j.scitotenv.2014.07.111

Svan, 2016, Identification of transformation products from β-blocking agents formed in wetland microcosms using LC-Q-ToF, J. Mass Spectrom., 51, 207, 10.1002/jms.3737

Tay, 2011, Characterization of atenolol transformation products in ozonation by using rapid resolution high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry, Microchem. J., 99, 312, 10.1016/j.microc.2011.05.022

Ternes, 2004, A rapid method to measure the solid-water distribution coefficient (K-d) for pharmaceuticals and musk fragrances in sewage sludge, Water Res., 38, 4075, 10.1016/j.watres.2004.07.015

Triebskorn, 2007, Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio), Anal. Bioanal. Chem., 387, 1405, 10.1007/s00216-006-1033-x

van den Born, 2005, Atenolol or metoprolol as beta-blocker in the treatment of hypertension, Ned. Tijdschr. Geneeskd., 149, 1808

Wadworth, 1991, Atenolol - a reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders, Drugs, 42, 468, 10.2165/00003495-199142030-00007

Wiffen, 2005, Carbamazepine for acute and chronic pain, Cochrane Database Syst. Rev., 3, 1

Wiffen, 2014, Carbamazepine for chronic neuropathic pain and fibromyalgia in adults, Cochrane Database Syst. Rev., 4, 1

World Health Organization, 2013

Yatham, 1988, Carbamazepine in the treatment of aggression - a case-report and a review of the literature, Acta psychiat. Scand., 78, 188, 10.1111/j.1600-0447.1988.tb06321.x

Yu, 2013, Sorption and degradation of pharmaceuticals and personal care products (PPCPs) in soils, Environ. Sci. Pollut. R., 20, 4261, 10.1007/s11356-012-1442-7

Zhang, 2007, Adjunctive herbal medicine with carbamazepine for bipolar disorders: a double-blind, randomized, placebo-controlled study, J. Psychiat. Res., 41, 360, 10.1016/j.jpsychires.2005.06.002