Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs)

Genes and Diseases - Tập 6 - Trang 258-275 - 2019
Linghuan Zhang1,2, Qing Luo1,2, Yi Shu1,2, Zongyue Zeng2,3,4, Bo Huang2,3,4,5, Yixiao Feng2,3,4, Bo Zhang2,6, Xi Wang2,3,4, Yan Lei2,3,4, Zhenyu Ye2,7, Ling Zhao2,3,4, Daigui Cao2,3,4, Lijuan Yang2,6, Xian Chen2,8, Bin Liu2,9, William Wagstaff2, Russell R. Reid10, Hue H. Luu2, Rex C. Haydon2, Michael J. Lee2
1Stem Cell Biology and Therapy Laboratory, Ministry of Education Key Laboratory of Child Development and Disorders, The Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
2Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA
3Ministry of Education Key Laboratory of Diagnostic Medicine, School of Laboratory Medicine, Chicago, IL 60637, USA
4The Affiliated Hospitals of Chongqing Medical University, Chongqing 400016, China
5Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
6Key Laboratory of Orthopaedic Surgery of Gansu Province, Departments of Orthopaedic Surgery and Obstetrics and Gynecology, The First and Second Hospitals of Lanzhou University, Lanzhou 730030, China
7Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
8Department of Clinical Laboratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266061, China
9Department of Biology, School of Life Sciences, Southwest University, Chongqing 400715, China
10Department of Surgery Section of Plastic Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA

Tài liệu tham khảo

Friedenstein, 1968, Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues, Transplantation, 6, 230, 10.1097/00007890-196803000-00009

Bianco, 2014, “Mesenchymal” stem cells, Annu Rev Cell Dev Biol, 30, 677, 10.1146/annurev-cellbio-100913-013132

Shenaq, 2010, Mesenchymal progenitor cells and their orthopedic applications: forging a path towards clinical trials, Stem Cells Int, 2010, 519028, 10.4061/2010/519028

Rastegar, 2010, Mesenchymal stem cells: molecular characteristics and clinical applications, World J Stem Cells, 2, 67, 10.4252/wjsc.v2.i4.67

Deng, 2008, Regulation of osteogenic differentiation during skeletal development, Front Biosci, 13, 2001, 10.2741/2819

Kim, 2013, Wnt signaling in bone formation and its therapeutic potential for bone diseases, Ther Adv Musculoskelet Dis, 5, 13, 10.1177/1759720X12466608

Yang, 2016, The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies, Lab Invest, 96, 116, 10.1038/labinvest.2015.144

Luther, 2011, BMP-9 induced osteogenic differentiation of mesenchymal stem cells: molecular mechanism and therapeutic potential, Curr Gene Ther, 11, 229, 10.2174/156652311795684777

Hogan, 1996, Bone morphogenetic proteins: multifunctional regulators of vertebrate development, Genes Dev, 10, 1580, 10.1101/gad.10.13.1580

Attisano, 2002, Signal transduction by the TGF-beta superfamily, Science, 296, 1646, 10.1126/science.1071809

Wang, 2014, Bone Morphogenetic Protein (BMP) signaling in development and human diseases, Genes Dis, 1, 87, 10.1016/j.gendis.2014.07.005

Zhao, 2003, Consequences of knocking out BMP signaling in the mouse, Genesis, 35, 43, 10.1002/gene.10167

Shi, 2003, Mechanisms of TGF-beta signaling from cell membrane to the nucleus, Cell, 113, 685, 10.1016/S0092-8674(03)00432-X

Luu, 2007, Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells, J Orthop Res, 25, 665, 10.1002/jor.20359

Bolt, 2007, BMP-14 gene therapy increases tendon tensile strength in a rat model of Achilles tendon injury, J Bone Joint Surg Am, 89, 1315, 10.2106/00004623-200706000-00021

Cheng, 2003, Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs), J Bone Joint Surg Am, 85-A, 1544, 10.2106/00004623-200308000-00017

Kang, 2004, Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery, Gene Ther, 11, 1312, 10.1038/sj.gt.3302298

Lamplot, 2013, BMP9 signaling in stem cell differentiation and osteogenesis, Am J Stem Cells, 2, 1

Peng, 2003, Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling, J Cell Biochem, 90, 1149, 10.1002/jcb.10744

Peng, 2004, Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells, J Biol Chem, 279, 32941, 10.1074/jbc.M403344200

Luo, 2004, Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells, J Biol Chem, 279, 55958, 10.1074/jbc.M407810200

Sharff, 2009, Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells, J Biol Chem, 284, 649, 10.1074/jbc.M806389200

Tang, 2009, BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling, J Cell Mol Med, 13, 2448, 10.1111/j.1582-4934.2008.00569.x

Huang, 2012, Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells, J Bone Miner Res, 27, 1566, 10.1002/jbmr.1622

Liao, 2017, Notch signaling augments BMP9-induced bone formation by promoting the osteogenesis–angiogenesis coupling process in mesenchymal stem cells (MSCs), Cell Physiol Biochem, 41, 1905, 10.1159/000471945

Liao, 2017, lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling, Oncotarget, 8, 53581, 10.18632/oncotarget.18655

Hu, 2013, BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells, J Cell Sci, 126, 532, 10.1242/jcs.114231

Wu, 2014, Overexpression of Ad5 precursor terminal protein accelerates recombinant adenovirus packaging and amplification in HEK-293 packaging cells, Gene Ther, 21, 629, 10.1038/gt.2014.40

Wei, 2017, Engineering the rapid adenovirus production and amplification (RAPA) cell line to expedite the generation of recombinant adenoviruses, Cell Physiol Biochem, 41, 2383, 10.1159/000475909

Huang, 2012, Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential, PLoS One, 7, e32428, 10.1371/journal.pone.0032428

Fan, 2017, Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors, Oncotarget, 8, 27105, 10.18632/oncotarget.15637

Zeng, 2018, The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs, Genes Dis, 5, 62, 10.1016/j.gendis.2018.02.001

He, 1998, A simplified system for generating recombinant adenoviruses, Proc Natl Acad Sci U S A, 95, 2509, 10.1073/pnas.95.5.2509

Luo, 2007, A protocol for rapid generation of recombinant adenoviruses using the AdEasy system, Nat Protoc, 2, 1236, 10.1038/nprot.2007.135

Kang, 2009, A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells, Stem Cells Dev, 18, 545, 10.1089/scd.2008.0130

Wang, 2014, Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla, Stem Cells Dev, 23, 1405, 10.1089/scd.2013.0580

Wang, 2017, NEL-like molecule-1 (Nell1) is regulated by bone morphogenetic protein 9 (BMP9) and potentiates BMP9-induced osteogenic differentiation at the expense of adipogenesis in mesenchymal stem cells, Cell Physiol Biochem, 41, 484, 10.1159/000456885

Li, 2014, Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signaling, Curr Cancer Drug Targets, 14, 274, 10.2174/1568009614666140305105805

Huang, 2009, Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells, Liver Int, 29, 1569, 10.1111/j.1478-3231.2009.02111.x

Bi, 2009, Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells, J Cell Biochem, 108, 295, 10.1002/jcb.22254

Zhao, 2014, Adenovirus-mediated gene transfer in mesenchymal stem cells can be significantly enhanced by the cationic polymer polybrene, PLoS One, 9, e92908, 10.1371/journal.pone.0092908

Si, 2006, CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells, Mol Cell Biol, 26, 2955, 10.1128/MCB.26.8.2955-2964.2006

Wen, 2014, Characterization of constitutive promoters for piggyBac transposon-mediated stable transgene expression in mesenchymal stem cells (MSCs), PLoS One, 9, e94397, 10.1371/journal.pone.0094397

Yu, 2018, Niclosamide exhibits potent anticancer activity and synergizes with Sorafenib in human renal cell cancer cells, Cell Physiol Biochem, 47, 957, 10.1159/000490140

Hu, 2017, CRISPR/Cas9-mediated reversibly immortalized mouse bone marrow stromal stem cells (BMSCs) retain multipotent features of mesenchymal stem cells (MSCs), Oncotarget, 8, 111847, 10.18632/oncotarget.22915

Song, 2017, BMP9 induces osteogenesis and adipogenesis in the immortalized human cranial suture progenitors from the patent sutures of craniosynostosis patients, J Cell Mol Med, 21, 2782, 10.1111/jcmm.13193

Liao, 2017, Characterization of retroviral infectivity and superinfection resistance during retrovirus-mediated transduction of mammalian cells, Gene Ther, 24, 333, 10.1038/gt.2017.24

Zhang, 2015, TqPCR: a touchdown qPCR assay with significantly improved detection sensitivity and amplification efficiency of SYBR green qPCR, PLoS One, 10, e0132666, 10.1371/journal.pone.0132666

Wang, 2017, WebMeV: a cloud platform for analyzing and visualizing cancer genomic data, Cancer Res, 77, e11, 10.1158/0008-5472.CAN-17-0802

Lamplot, 2015, Reversibly immortalized mouse articular chondrocytes acquire long-term proliferative capability while retaining chondrogenic phenotype, Cell Transplant, 24, 1053, 10.3727/096368914X681054

Daluiski, 2001, Bone morphogenetic protein-3 is a negative regulator of bone density, Nat Genet, 27, 84, 10.1038/83810

Wang, 2013, Noggin resistance contributes to the potent osteogenic capability of BMP9 in mesenchymal stem cells, J Orthop Res, 31, 1796, 10.1002/jor.22427

Luo, 2008, Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects, Lab Invest, 88, 1264, 10.1038/labinvest.2008.98

Luo, 2010, TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells, J Biol Chem, 285, 29588, 10.1074/jbc.M110.130518

Aubin, 2004, In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis, Genes Dev, 18, 1482, 10.1101/gad.1202604

Broege, 2013, Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis, J Biol Chem, 288, 37230, 10.1074/jbc.M113.496950

Wagner, 2011, The therapeutic potential of the Wnt signaling pathway in bone disorders, Curr Mol Pharmacol, 4, 14, 10.2174/1874467211104010014

Lee, 2009, Smad, PI3K/Akt, and Wnt-dependent signaling pathways are involved in BMP-4-induced ESC self-renewal, Stem cells, 27, 1858, 10.1002/stem.124

Rocher, 2013, SMAD–PI3K–Akt–mTOR pathway mediates BMP-7 polarization of monocytes into M2 macrophages, PLoS One, 8, e84009, 10.1371/journal.pone.0084009

Lee, 2010, Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway, Stem Cells Dev, 19, 557, 10.1089/scd.2009.0147

Chen, 2018, mTOR signaling in skeletal development and disease, Bone Res, 6, 1, 10.1038/s41413-017-0004-5

Kakoi, 2014, Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism, J Biol Chem, 289, 8135, 10.1074/jbc.M113.509331

Ricard, 2012, BMP9 and BMP10 are critical for postnatal retinal vascular remodeling, Blood, 119, 6162, 10.1182/blood-2012-01-407593

Paul, 2003, Potential use of Sox9 gene therapy for intervertebral degenerative disc disease, Spine, 28, 755, 10.1097/01.BRS.0000058946.64222.92