Toxicity of Deoxynivalenol and Its Acetylated Derivatives on the Intestine: Differential Effects on Morphology, Barrier Function, Tight Junction Proteins, and Mitogen-Activated Protein Kinases
Tóm tắt
Từ khóa
Tài liệu tham khảo
Awad, (2007), In vitro effects of deoxynivalenol on small intestinal D-glucose uptake and absorption of deoxynivalenol across the isolated jejunal epithelium of laying hens., Poult. Sci., 86, 15, 10.1093/ps/86.1.15
Bensassi, (2009), Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells., Toxicology, 264, 104, 10.1016/j.tox.2009.07.020
Berek, (2001), Effects of mycotoxins on human immune functions in vitro., Toxicol. In Vitro, 15, 25, 10.1016/S0887-2333(00)00055-2
Bondy, (1991), Murine lymphocyte proliferation impaired by substituted neosolaniols and calonectrins–Fusarium metabolites associated with trichothecene biosynthesis., Toxicon, 29, 1107, 10.1016/0041-0101(91)90208-9
Bondy, (1991), Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer’s patch B cells to IgA secreting plasma cells., Toxicol. Appl. Pharmacol., 108, 520, 10.1016/0041-008X(91)90098-Y
Bouhet, (2006), Mycotoxin fumonisin B1 selectively down-regulates the basal IL-8 expression in pig intestine: In vivo and in vitro studies., Food Chem. Toxicol., 44, 1768, 10.1016/j.fct.2006.05.018
Bracarense, (2012), Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets., Br. J. Nutr., 107, 1776, 10.1017/S0007114511004946
Canady, (2001), Deoxynivalenol. Safety evaluation of certain mycotoxins in food, WHO Food Additives Series, 47, 420
Desjardins, (2007), Structure-activity relationships of trichothecene toxins in an Arabidopsis thaliana leaf assay., J. Agric. Food Chem., 55, 6487, 10.1021/jf0709193
Diesing, (2011), Vulnerability of polarised intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application., PLoS ONE, 6, e17472, 10.1371/journal.pone.0017472
Doyle, (2009), Intracellular expression of a single domain antibody reduces cytotoxicity of 15-acetyldeoxynivalenol in yeast., J. Biol. Chem., 284, 35029, 10.1074/jbc.M109.045047
European Commission, (1999), 1
European Commission., (2003), 1
European Union, (2005)
FAO, (2004)
FAO, (2010)
FDA, (2010)
Forsell, (1987), Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse., Food Chem. Toxicol., 25, 155, 10.1016/0278-6915(87)90149-9
Forsell, (1985), Relation of 8-ketotrichothecene and zearalenone analog structure to inhibition of mitogen-induced human lymphocyte blastogenesis., Appl. Environ. Microbiol., 50, 1304, 10.1128/AEM.50.5.1304-1307.1985
Kasuga, (1998), In vitro effect of deoxynivalenol on the differentiation of human colonic cell lines Caco-2 and T84., Mycopathologia, 142, 161, 10.1023/A:1006923808748
Kolf-Clauw, (2009), Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: Histopathological analysis., Toxicol. In Vitro, 23, 1580, 10.1016/j.tiv.2009.07.015
Larsson, (2002), Conformational changes in the structure of domains II and V of 28S rRNA in ribosomes treated with the translational inhibitors ricin or alpha-sarcin., Biochim. Biophys. Acta, 1577, 53, 10.1016/S0167-4781(02)00406-2
Li, (2005), Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol., Toxicol. Sci., 87, 134, 10.1093/toxsci/kfi225
Li, (2008), Comparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage., Toxicol. Sci., 105, 67, 10.1093/toxsci/kfn111
Maresca, (2010), Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases., Toxicon, 56, 282, 10.1016/j.toxicon.2010.04.016
Maresca, (2008), Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: Stimulation of interleukin-8 secretion, potentiation of interleukin-1beta effect and increase in the transepithelial passage of commensal bacteria., Toxicol. Appl. Pharmacol., 228, 84, 10.1016/j.taap.2007.11.013
Moon, (2012), Cellular alterations of mucosal integrity by ribotoxins: Mechanistic implications of environmentally-linked epithelial inflammatory diseases., Toxicon, 59, 192, 10.1016/j.toxicon.2011.11.010
Ouyang, (1995), Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells., Toxicology, 104, 187, 10.1016/0300-483X(95)03147-8
Pestka, (2010), Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance., Arch. Toxicol., 84, 663, 10.1007/s00204-010-0579-8
Pinton, (2008), Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses., Toxicol. Lett., 177, 215, 10.1016/j.toxlet.2008.01.015
Pinton, (2010), Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism., J. Nutr., 140, 1956, 10.3945/jn.110.123919
Pinton, (2012), Effects of some fungal toxins, the trichothecenes, on the intestine, Curr. Immunol. Rev., 8, 193, 10.2174/157339512800671967
Pinton, (2009), The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression., Toxicol. Appl. Pharmacol., 237, 41, 10.1016/j.taap.2009.03.003
Raman, (2007), Differential regulation and properties of MAPKs., Oncogene, 26, 3100, 10.1038/sj.onc.1210392
Sergent, (2006), Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations., Toxicol. Lett., 164, 167, 10.1016/j.toxlet.2005.12.006
Steinmetz, (2009), 3D QSAR study of the toxicity of trichothecene mycotoxins., Eur. J. Med. Chem., 44, 4485, 10.1016/j.ejmech.2009.06.012
Sugita-Konishi, (2001), Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model., J. Toxicol. Environ. Health Part A, 64, 619, 10.1080/152873901753246223
Van De Walle, (2010), Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis, Toxicol. Appl. Pharmacol., 245, 291, 10.1016/j.taap.2010.03.012
Yang, (2010), Mechanism-based alternative monitoring of endoplasmic reticulum stress by 8-keto-trichothecene mycotoxins using human intestinal epithelial cell line., Toxicol. Lett., 198, 317, 10.1016/j.toxlet.2010.07.008
