Các chế phẩm điều trị IVIg chứa kháng thể chống HLA-E tự nhiên có khả năng phản ứng với các alen HLA-Ia (HLA-A/-B/-Cw)

Blood - Tập 121 - Trang 2013-2028 - 2013
Mepur H. Ravindranath1, Paul I. Terasaki1, Tho Pham1, Vadim Jucaud1, Satoru Kawakita1
1Terasaki Foundation Laboratory, Los Angeles, CA

Tóm tắt

Điểm chính Các chế phẩm điều trị của IVIg có mức độ phản ứng cao với HLA (Ia và Ib). Các kháng thể đơn dòng chống HLA-E (anti–HLA-E mAbs) bắt chước phản ứng HLA-I của IVIg. Các kháng thể đơn dòng chống HLA-E có thể hữu ích trong việc ức chế sản xuất kháng thể HLA tương tự như IVIg và theo cách mà các kháng thể chống RhD (anti-RhD Abs) ức chế sản xuất.

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Tài liệu tham khảo

Negi, 2007, Intravenous immunoglobulin: an update on the clinical use and mechanisms of action., J Clin Immunol, 27, 233, 10.1007/s10875-007-9088-9 Glotz, 1993, Suppression of HLA-specific alloantibodies by high-dose intravenous immunoglobulins (IVIg). A potential tool for transplantation of immunized patients., Transplantation, 56, 335, 10.1097/00007890-199308000-00015 Tyan, 1994, Intravenous immunoglobulin suppression of HLA alloantibody in highly sensitized transplant candidates and transplantation with a histoincompatible organ., Transplantation, 57, 553, 10.1097/00007890-199402270-00014 Jordan, 1998, Posttransplant therapy using high-dose human immunoglobulin (intravenous gammaglobulin) to control acute humoral rejection in renal and cardiac allograft recipients and potential mechanism of action., Transplantation, 66, 800, 10.1097/00007890-199809270-00017 Montgomery, 2000, Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients., Transplantation, 70, 887, 10.1097/00007890-200009270-00006 Nair, 2012, Effect of high-dose intravenous immunoglobulin on anti-HLA antibodies in sensitized kidney transplant candidates., Clin Transplant, 26, E261, 10.1111/j.1399-0012.2012.01657.x Alachkar, 2012, Infusion of high-dose intravenous immunoglobulin fails to lower the strength of human leukocyte antigen antibodies in highly sensitized patients., Transplantation, 94, 165, 10.1097/TP.0b013e318253f7b6 Marfo, 2012, Lack of effect in desensitization with intravenous immunoglobulin and rituximab in highly sensitized patients., Transplantation, 94, 345, 10.1097/TP.0b013e3182590d2e Tongio, 1985, Natural HLA antibodies., Tissue Antigens, 26, 271, 10.1111/j.1399-0039.1985.tb02225.x Luscher, 1998, Anti-HLA alloAb is found in children but does not correlate with a lack of HIV type 1 transmission from infected mothers., AIDS Res Hum Retroviruses, 14, 99, 10.1089/aid.1998.14.99 Morales-Buenrostro, 2008, “Natural” human leukocyte antigen antibodies found in nonalloimmunized healthy males., Transplantation, 86, 1111, 10.1097/TP.0b013e318186d87b Zhou, 2008, Existence of an immunoglobulin G component of naturally occurring HLA class I antibodies that are not directed against self-antigens in human serum., Tissue Antigens, 72, 98, 10.1111/j.1399-0039.2008.01074.x Ravindranath, 2010, Antibodies to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera., J Immunol, 185, 1935, 10.4049/jimmunol.1000424 Ravindranath, 2010, HLA-E monoclonal antibodies recognize shared peptide sequences on classical HLA class Ia: relevance to human natural HLA antibodies., Mol Immunol, 47, 1121, 10.1016/j.molimm.2009.10.024 Ravindranath, 2011, Anti-HLA-E mAb 3D12 mimics MEM-E/02 in binding to HLA-B and HLA-C alleles: Web-tools validate the immunogenic epitopes of HLA-E recognized by the antibodies., Mol Immunol, 48, 423, 10.1016/j.molimm.2010.09.011 Derré, 2006, Expression and release of HLA-E by melanoma cells and melanocytes: potential impact on the response of cytotoxic effector cells., J Immunol, 177, 3100, 10.4049/jimmunol.177.5.3100 Coupel, 2007, Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation., Blood, 109, 2806, 10.1182/blood-2006-06-030213 Ravindranath, 2012, Augmentation of anti-HLA-E antibodies with concomitant HLA-Ia reactivity in IFNγ-treated autologous melanoma cell vaccine recipients., J Immunotoxicol, 9, 282, 10.3109/1547691X.2011.645582 Ravindranath, 2012, Antibodies to HLA-E may account for the non-donor-specific anti-HLA class-Ia antibodies in renal and liver transplant recipients., Int Immunol, 24, 43, 10.1093/intimm/dxr094 Ward, 1999, Monoclonal Antibody Production A Report of the, 1 Sansonno, 1986, An enzyme-linked immunosorbent assay for the detection of autoantibodies to albumin., J Immunol Methods, 90, 131, 10.1016/0022-1759(86)90393-5 Pires, 2006, Naturally occurring anti-albumin antibodies are responsible for false positivity in diagnosis of autoimmune premature ovarian failure., J Histochem Cytochem, 54, 397, 10.1369/jhc.5A6778.2005 Hoppe, 1979, [Antibody screening of commercially available immunoglobulins. Erythrocyte-, HLA- and autoantibodies (author’s transl)]., Blut, 39, 9, 10.1007/BF01008070 Kaveri, 1996, Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use., J Clin Invest, 97, 865, 10.1172/JCI118488 Stoclin, 2013, Transfusion-related acute lung injury after intravenous immunoglobulin treatment in a lung transplant recipient., Vox Sang, 104, 175, 10.1111/j.1423-0410.2012.01645.x Ghio, 2000, The immunomodulatory effect of blood transfusions and intravenous immunoglobulins: the role of the soluble molecules of the Class-I major histocompatibility complex and of the Fas ligand., Ann Ital Med Int, 15, 70 Barocci, 1990, Anti-HLA antibodies (Ab1) and anti-idiotypic antibodies (Ab2) directed against Anti-HLA Ab1 in various preparations of polyspecific immunoglobulins for intravenous use., Boll Soc Ital Biol Sper, 66, 1193 Ott, 2001, Fc gamma RIIB as a potential molecular target for intravenous gamma globulin therapy., J Allergy Clin Immunol, 108, S95, 10.1067/mai.2001.117822 Heidt Sibéril, 2006, Selection of a human anti-RhD monoclonal antibody for therapeutic use: impact of IgG glycosylation on activating and inhibitory Fc γ R functions., Clin Immunol, 118, 170, 10.1016/j.clim.2005.10.008 Brinc, 2009;2009, Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn., Hematology (Am Soc Hematol Educ Program), (1), 185, 10.1182/asheducation-2009.1.185 Heyman, 2000, Regulation of antibody responses via antibodies, complement, and Fc receptors., Annu Rev Immunol, 18, 709, 10.1146/annurev.immunol.18.1.709 Uhr, 1968, Regulatory effect of antibody on the immune response., Adv Immunol, 8, 81, 10.1016/S0065-2776(08)60465-4 Santoso, 1992, Quantitation of soluble HLA class I antigen in human albumin and immunoglobulin preparations for intravenous use by solid-phase immunoassay., Vox Sang, 62, 29, 10.1159/000462159 Grosse-Wilde, 1992, Soluble HLA class I and class II concentrations in commercial immunoglobulin preparations., Tissue Antigens, 39, 74, 10.1111/j.1399-0039.1992.tb01910.x Blasczyk, 1993, Soluble CD4, CD8, and HLA molecules in commercial immunoglobulin preparations., Lancet, 341, 789, 10.1016/0140-6736(93)90563-V El-Awar, 2009, Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood., Hum Immunol, 70, 844, 10.1016/j.humimm.2009.06.020 Rizk, 2001, Transfusion-related acute lung injury after the infusion of IVIG., Transfusion, 41, 264, 10.1046/j.1537-2995.2001.41020264.x Dooren, 1998, Adult respiratory distress syndrome after experimental intravenous gamma-globulin concentrate and monocyte-reactive IgG antibodies., Lancet, 352, 1601, 10.1016/S0140-6736(05)61049-5 Berger-Achituv, 2008, Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent., Am J Hematol, 83, 676, 10.1002/ajh.21185 Voulgari, 2010, Images in rheumatology. Transfusion-related acute lung injury during intravenous immunoglobulin treatment., J Rheumatol, 37, 190, 10.3899/jrheum.090725 Gupta, 2011, Transfusion related acute lung injury with intravenous immunoglobulin., Indian Pediatr, 48, 807 Newburger, 1986, The treatment of Kawasaki syndrome with intravenous gamma globulin., N Engl J Med, 315, 341, 10.1056/NEJM198608073150601 Lin, 2009, HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms., Arthritis Rheum, 60, 604, 10.1002/art.24261 Allard, 2011, Serum soluble HLA-E in melanoma: a new potential immune-related marker in cancer., PLoS ONE, 6, e21118, 10.1371/journal.pone.0021118 Pellegrino, 1982, Immunogenicity of serum HLA antigens in allogeneic combinations., Transplantation, 33, 530, 10.1097/00007890-198205000-00013