Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases

Springer Science and Business Media LLC - Tập 58 Số 8 - Trang 1297-1306 - 2009
Anna Maria Di Giacomo1, Riccardo Danielli1, Massimo Giusti1, Luana Calabrò1, Dora Carlucci1, Clelia Miracco2, Luca Volterrani3, Maria Antonietta Mazzei3, Maurizio Biagioli4, Maresa Altomonte1, Michele Maio5
1Division of Medical Oncology and Immunotherapy, Istituto Toscano Tumori, University Hospital of Siena, Siena, Italy
2Department of Pathology, Istituto Toscano Tumori, University Hospital of Siena, Siena, Italy
3Department of Radiology, Istituto Toscano Tumori, University Hospital of Siena, Siena, Italy
4Division of Dermatology, Istitutto Toscano Tumori, University Hospital of Siena, Siena, Italy
5Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy.

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