The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6:29–40. doi: 10.1038/nrd2201
Levy SB, Marshall B (2004) Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 10:S122–S129. doi: 10.1038/nm1145
Paterson DL (2006) The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin Infect Dis 43:S43–S48. doi: 10.1086/504476
Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J Jr; Infectious Diseases Society of America (2008) The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis 46:155–164. doi: 10.1086/524891
Goldstein F (2007) The potential clinical impact of low-level antibiotic resistance in Staphylococcus aureus. J Antimicrob Chemother 59:1–4. doi: 10.1093/jac/dkl429
Cui LZ, Iwamoto A, Lian JQ, Neoh HM, Maruyama T, Horikawa Y, Hiramatsu K (2006) Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother 50:428–438. doi: 10.1128/AAC.50.2.428-438.2006
Quentin C, Arpin C, Dubois V, André C, Lagrange I, Fischer I, Brochet JP, Grobost F, Jullin J, Dutilh B, Larribet G, Noury P (2004) Antibiotic resistance rates and phenotypes among isolates of Enterobacteriaceae in French extra-hospital practice. Eur J Clin Microbiol Infect Dis 23:185–193. doi: 10.1007/s10096-003-1081-5
Jain R, Danziger LH (2004) Multidrug-resistant Acinetobacter infections: an emerging challenge to clinicians. Ann Pharmacother 38:1449–1459. doi: 10.1345/aph.1D592
Hujer KM, Hujer AM, Hulten EA, Bajaksouzian S, Adams JM, Donskey CJ, Ecker DJ, Massire C, Eshoo MW, Sampath R, Thomson JM, Rather PN, Craft DW, Fishbain JT, Ewell AJ, Jacobs MR, Paterson DL, Bonomo RA (2006) Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother 50:4114–4123. doi: 10.1128/AAC.00778-06
O’Callaghan A, Redmond HP (2006) Treatment of sepsis: current status of clinical immunotherapy. Surgeon 4:355–361
Weigelt J, Itani K, Stevens D, Lau W, Dryden M, Knirsch C; Linezolid CSSTI Study Group (2005) Linezolid versus vancomycin in treatment of complicated skin and soft tissue infections. Antimicrob Agents Chemother 49:2260–2266. doi: 10.1128/AAC.49.6.2260-2266.2005
Livermore DM, Woodford N (2006) The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Trends Microbiol 14:413–420. doi: 10.1016/j.tim.2006.07.008
Molan PC (2006) The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 5:40–54. doi: 10.1177/1534734605286014
Gethin GT, Cowman S, Conroy RM (2008) The impact of Manuka honey dressings on the surface pH of chronic wounds. Int Wound J 5:185–194. doi: 10.1111/j.1742-481X.2007.00424.x
Lotfi A (2008) Use of honey as a medicinal product in wound dressing (human and animal studies): a review. Res J Bio Sci 3:136–140
Jull A, Walker N, Parag V, Molan P, Rodgers A; Honey as Adjuvant Leg Ulcer Therapy trial collaborators (2008) Randomized clinical trial of honey-impregnated dressings for venous leg ulcers. Br J Surg 95:175–182. doi: 10.1002/bjs.6059
Visavadia BG, Honeysett J, Danford MH (2008) Manuka honey dressing: an effective treatment for chronic wound infections. Br J Oral Maxillofac Surg 46:55–56. doi: 10.1016/j.bjoms.2006.09.013
Emsen IM (2007) A different and safe method of split thickness skin graft fixation: medical honey application. Burns 33:782–787. doi: 10.1016/j.burns.2006.12.005
Blaser G, Santos K, Bode U, Vetter H, Simon A (2007) Effect of medical honey on wounds colonised or infected with MRSA. J Wound Care 16:325–328
Simon A, Sofka K, Wiszniewsky G, Blaser G, Bode U, Fleischhack G (2006) Wound care with antibacterial honey (Medihoney) in pediatric hematology-oncology. Support Care Cancer 14:91–97. doi: 10.1007/s00520-005-0874-8
Molan PC (1992) The antibacterial activity of honey. 1. The nature of the antibacterial activity. Bee World 73:5–28
White JW Jr, Subers MH, Schepartz AI (1963) The identification of inhibine, the antibacterial factor in honey, as hydrogen peroxide and its origin in a honey glucose-oxidase system. Biochim Biophys Acta 73:57–70. doi: 10.1016/0006-3002(63)90359-7
Allen KL, Molan PC, Reid GM (1991) A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol 43:817–822
Adams CJ, Boult CH, Deadman BJ, Farr JM, Grainger MNC, Manley-Harris M, Snow MJ (2008) Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey. Carbohydr Res 343:651–659. doi: 10.1016/j.carres.2007.12.011
Mavric E, Wittmann S, Barth G, Henle T (2008) Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res 52:483–489. doi: 10.1002/mnfr.200700282
Kalapos MP (2008) The tandem of free radicals and methylglyoxal. Chem Biol Interact 171:251–271. doi: 10.1016/j.cbi.2007.11.009
Brazas MD, Hancock REW (2005) Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance. Drug Discov Today 10:1245–1252. doi: 10.1016/S1359-6446(05)03566-X
Hancock RE (2007) The complexities of antibiotic action. Mol Syst Biol 3:142. doi: 10.1038/msb4100184
Hutter B, Schaab C, Albrecht S, Borgmann M, Brunner NA, Freiberg C, Ziegelbauer K, Rock CO, Ivanov I, Loferer H (2004) Prediction of mechanisms of action of antibacterial compounds by gene expression profiling. Antimicrob Agents Chemother 48:2838–2844. doi: 10.1128/AAC.48.8.2838-2844.2004
Freiberg C, Brötz-Oesterhelt H, Labischinski H (2004) The impact of transcriptome and proteome analyses on antibiotic drug discovery. Curr Opin Microbiol 7:451–459. doi: 10.1016/j.mib.2004.08.010
Davies J, Spiegelman GB, Yim G (2006) The world of subinhibitory antibiotic concentrations. Curr Opin Microbiol 9:445–453. doi: 10.1016/j.mib.2006.08.006
Lange RP, Locher HH, Wyss PC, Then RL (2007) The targets of currently used antibacterial agents: lessons for drug discovery. Curr Pharm Des 13:3140–3154. doi: 10.2174/138161207782110408
Alvarez J, Vicente M (2007) Using genomics to identify new targets and counteract resistance to antibiotics. Expert Opin Ther Pat 17:667–674
Cooper RA, Molan PC, Harding KG (2002) The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol 93:857–863. doi: 10.1046/j.1365-2672.2002.01761.x
NCCLS (2000) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. NCCLS Document Approved Standard—Fifth edition
Rimsky S (2004) Structure of the histone-like protein H-NS and its role in regulation and genome superstructure. Curr Opin Microbiol 7:109–114. doi: 10.1016/j.mib.2004.02.001
Marles-Wright J, Lewis RJ (2007) Stress responses of bacteria. Curr Opin Struct Biol 17:755–760. doi: 10.1016/j.sbi.2007.08.004
Hengge-Aronis R (2002) Signal transduction and regulatory mechanisms involved in control of the σS RpoS subunit of RNA polymerase. Microbiol Mol Biol Rev 66:373–395. doi: 10.1128/MMBR.66.3.373-395.2002
Dong T, Kirchhof MG, Schellhorn HE (2008) RpoS regulation of gene expression during exponential growth of Escherichia coli K12. Mol Genet Genomics 279:267–277. doi: 10.1007/s00438-007-0311-4
Eguchi Y, Oshima T, Mori H, Aono R, Yamamoto K, Ishihama A, Utsumi R (2003) Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli. Microbiology 149:2819–2828. doi: 10.1099/mic.0.26460-0
Eguchi Y, Okada T, Minagawa S, Oshima T, Mori H, Yamamoto K, Ishihama A, Utsumi R (2004) Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli. J Bacteriol 186:3006–3014. doi: 10.1128/JB.186.10.3006-3014.2004
Simon A, Traynor K, Santos K, Blaser G, Bode U, Molan P (2009) Medical honey for wound care—still the ‘latest resort’? eCAM 6:165–173. doi: 10.1093/ecam/nem175
Blair SE, Carter DA (2005) The potential for honey in the management of wounds and infection. Aust Infect Contr 10:24–31
Cooper RA, Wigley P, Burton NF (2000) Susceptibility of multiresistant strains of Burkholderia cepacia to honey. Lett Appl Microbiol 31:20–24. doi: 10.1046/j.1472-765x.2000.00756.x
Cooper RA, Halas E, Molan PC (2002) The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. J Burn Care Rehabil 23:366–370. doi: 10.1097/00004630-200211000-00002
French VM, Cooper RA, Molan PC (2005) The antibacterial activity of honey against coagulase-negative staphylococci. J Antimicrob Chemother 56:228–231. doi: 10.1093/jac/dki193
Braoudaki M, Hilton AC (2004) Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents. J Clin Microbiol 42:73–78. doi: 10.1128/JCM.42.1.73-78.2004
Booth IR, Ferguson GP, Miller S, Li C, Gunasekera B, Kinghorn S (2003) Bacterial production of methylglyoxal: a survival strategy or death by misadventure? Biochem Soc Trans 31:1406–1408. doi: 10.1042/BST0311406
Crane E (1976) Honey, a comprehensive survey. London: Heinemann (for the Bee Research Association), p 608
Moreillon P (2000) Means of bacterial resistance. Rev Med Suisse Romande 120:641–650
Levy SB (2002) Active efflux, a common mechanism for biocide and antibiotic resistance. J Appl Microbiol 92:65S–71S. doi: 10.1046/j.1365-2672.92.5s1.4.x
Kaldalu N, Mei R, Lewis K (2004) Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile. Antimicrob Agents Chemother 48:890–896. doi: 10.1128/AAC.48.3.890-896.2004
Herold S, Siebert J, Huber A, Schmidt H (2005) Global expression of prophage genes in Escherichia coli O157:H7 strain EDL933 in response to norfloxacin. Antimicrob Agents Chemother 49:931–944. doi: 10.1128/AAC.49.3.931-944.2005
Goh EB, Yim G, Tsui W, McClure J, Surette MG, Davies J (2002) Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc Natl Acad Sci USA 99:17025–17030. doi: 10.1073/pnas.252607699
Hong RW, Shchepetov M, Weiser JN, Axelsen PH (2003) Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrob Agents Chemother 47:1–6. doi: 10.1128/AAC.47.1.1-6.2003
Tomasinsig L, Scocchi M, Mettulio R, Zanetti M (2004) Genome-wide transcriptional profiling of the Escherichia coli response to a proline-rich antimicrobial peptide. Antimicrob Agents Chemother 48:3260–3267. doi: 10.1128/AAC.48.9.3260-3267.2004
Khil PP, Camerini-Otero RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol Microbiol 44:89–105. doi: 10.1046/j.1365-2958.2002.02878.x
Chang DE, Smalley DJ, Conway T (2002) Gene expression profiling of Escherichia coli growth transitions: an expanded stringent response model. Mol Microbiol 45:289–306. doi: 10.1046/j.1365-2958.2002.03001.x
Hengge-Aronis R (1996) Back to log phase: sigma S as a global regulator in the osmotic control of gene expression in Escherichia coli. Mol Microbiol 21:887–893. doi: 10.1046/j.1365-2958.1996.511405.x
Ferguson GP, Creighton RI, Nikolaev Y, Booth IR (1998) Importance of RpoS and Dps in survival of exposure of both exponential- and stationary-phase Escherichia coli cells to the electrophile N-ethylmaleimide. J Bacteriol 180:1030–1036
Seputiene V, Daugelavicius A, Suziedelis K, Suziedeliene E (2006) Acid response of exponentially growing Escherichia coli K-12. Microbiol Res 161:65–74. doi: 10.1016/j.micres.2005.06.002
van Baarlen P, van Belkum A, Summerbell RC, Crous PW, Thomma BPHJ (2007) Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps? FEMS Microbiol Rev 31:239–277. doi: 10.1111/j.1574-6976.2007.00065.x
Irish J, Carter DA, Shokohi T, Blair SE (2006) Honey has an antifungal effect against Candida species. Med Mycol 44:289–291. doi: 10.1080/13693780500417037
Brady NF, Molan PC, Harfoot CG (1996) The sensitivity of dermatophytes to the antimicrobial activity of manuka honey and other honey. Pharm Sci 2:471–473
Ferguson GP, Tötemeyer S, MacLean MJ, Booth IR (1998) Methylglyoxal production in bacteria: suicide or survival? Arch Microbiol 170:209–219. doi: 10.1007/s002030050635
Tötemeyer S, Booth NA, Nichols WW, Dunbar B, Booth IR (1998) From famine to feast: the role of methylglyoxal production in Escherichia coli. Mol Microbiol 27:553–562. doi: 10.1046/j.1365-2958.1998.00700.x
Clugston SL, Honek JF (2000) Identification of sequences encoding the detoxification metalloisomerase glyoxalase I in microbial genomes from several pathogenic organisms. J Mol Evol 50:491–495
Grant AW, Steel G, Waugh H, Ellis EM (2003) A novel aldo-keto reductase from Escherichia coli can increase resistance to methylglyoxal toxicity. FEMS Microbiol Lett 218:93–99. doi: 10.1111/j.1574-6968.2003.tb11503.x
Misra K, Banerjee AB, Ray S, Ray M (1995) Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione. Biochem J 305:999–1003