The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients
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Weinberg, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013
Ladomery, 2013, Aberrant Alternative Splicing Is Another Hallmark of Cancer, Int J Cell Biol, 2013, 463786, 10.1155/2013/463786
Castano, 2009, Identification and characterization of two novel truncated but functional isoforms of the somatostatin receptor subtype 5 differentially present in pituitary tumors, J Clin Endocrinol Metab, 94, 2634, 10.1210/jc.2008-2564
Zatelli, 2015, The expression of the truncated isoform of somatostatin receptor subtype 5 associates with aggressiveness in medullary thyroid carcinoma cells, Endocrine, 50, 442, 10.1007/s12020-015-0594-x
Gahete, 2015, Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation invasion and reduced octreotide response) to somatotropinomas, Cancer Lett, 359, 299, 10.1016/j.canlet.2015.01.037
Vidal, 2014, The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer, PLoS One, 9, e85527, 10.1371/journal.pone.0085527
Castano, 2012, The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells, Oncogene, 31, 2049, 10.1038/onc.2011.389
Castano, 2011, Truncated somatostatin receptors as new players in somatostatin-cortistatin pathophysiology, Ann N Y Acad Sci, 1220, 6, 10.1111/j.1749-6632.2011.05985.x
Castaño, 2010, A potential inhibitory role for the new truncated variant of somatostatin receptor 5 (sst5TMD4) in pituitary adenomas poorly responsive to somatostatin analogs, J Clin Endocrinol Metab, 95, 2497, 10.1210/jc.2009-2247
Rich, 2006, Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor, Cancer Res, 66, 7843, 10.1158/0008-5472.CAN-06-1010
Zakharenko, 2007, A perivascular niche for brain tumor stem cells, Cancer Cell, 11, 69, 10.1016/j.ccr.2006.11.020
Rich, 2008, Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis, J Clin Oncol, 26, 2839, 10.1200/JCO.2007.15.1829
Alitalo, 2009, Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system, Nat Rev Mol Cell Biol, 10, 165, 10.1038/nrm2639
Ferrara, 1993, Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo, Nature, 362, 841, 10.1038/362841a0
Benjamin, 2013, Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy, Cancer Res, 73, 1649, 10.1158/0008-5472.CAN-12-4697
Del Tacca, 1996, The effects of the somatostatin analog octreotide on angiogenesis in vitro, Metabolism, 45, 49, 10.1016/S0026-0495(96)90080-3
Bagnoli, 2011, Hypoxia effects on proangiogenic factors in human umbilical vein endothelial cells: functional role of the peptide somatostatin, Naunyn Schmiedebergs Arch Pharmacol, 383, 593, 10.1007/s00210-011-0625-y
Bagnoli, 2007, Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice, Invest Ophthalmol Vis Sci, 48, 3480, 10.1167/iovs.06-1469
Bagnoli, 2003, Somatostatin inhibits potassium-evoked glutamate release by activation of the sst(2) somatostatin receptor in the mouse retina, Naunyn Schmiedebergs Arch Pharmacol, 367, 188, 10.1007/s00210-002-0662-7
Held-Feindt, 2001, Somatostatin inhibits the production of vascular endothelial growth factor in human glioma cells, Int J Cancer, 92, 545, 10.1002/ijc.1223
Cai, 2011, A randomized trial of somatostatin to regulate the VEGFs/VEGFRs in patients with gastric cancer, Hepatogastroenterology, 58, 1425, 10.5754/hge10749
Qin, 2004, Mechanisms of inhibition of growth of human pancreatic carcinoma implanted in nude mice by somatostatin receptor subtype 2, Pancreas, 29, 141, 10.1097/00006676-200408000-00009
Qin, 2004, Anti-angiogenic effects of somatostatin receptor subtype 2 on human pancreatic cancer xenografts, Carcinogenesis, 25, 2075, 10.1093/carcin/bgh216
Qin, 2004, Antiangiogenic effect of somatostatin receptor subtype 2 on pancreatic cancer cell line: Inhibition of vascular endothelial growth factor and matrix metalloproteinase-2 expression in vitro, World J Gastroenterol, 10, 393, 10.3748/wjg.v10.i3.393
Florio, 2008, Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors, Front Biosci, 13, 822, 10.2741/2722
Lamberts, 1994, Somatostatin-receptor scintigraphy in primary breast cancer, Lancet, 343, 640, 10.1016/S0140-6736(94)92637-9
Cataliotti, 2004, Measurement of somatostatin receptor subtype 2 mRNA in breast cancer and corresponding normal tissue, Endocr Relat Cancer, 11, 323, 10.1677/erc.0.0110323
Kumar, 2008, Biology of somatostatin in breast cancer, Mol Cell Endocrinol, 286, 251, 10.1016/j.mce.2008.01.006
Martin, 2007, Mechanisms of disease: angiogenesis and the management of breast cancer, Nat Clin Pract Oncol, 4, 536, 10.1038/ncpneuro0859
Spiegelman, 2008, HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha, Nature, 451, 1008, 10.1038/nature06613
Massague, 2009, Metastasis: from dissemination to organ-specific colonization, Nat Rev Cancer, 9, 274, 10.1038/nrc2622
Groom, 1998, Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases, Am J Pathol, 153, 865, 10.1016/S0002-9440(10)65628-3
Kang, 2007, Beyond tumorigenesis: cancer stem cells in metastasis, Cell Res, 17, 3, 10.1038/sj.cr.7310118
Csiszar, 2011, Lysyl oxidase-like 2 (LOXL2) a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas, EMBO Mol Med, 3, 528, 10.1002/emmm.201100156
Drexler, 2005, Detection of mycoplasma contaminations, Methods Mol Biol, 290, 13
Castaño, 2011, A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance, PLoS One, 6, e23302, 10.1371/journal.pone.0023302
Malagon, 2006, Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas, J Clin Endocrinol Metab, 91, 2225, 10.1210/jc.2006-0235
Gadelha, 2009, Expression analysis of dopamine receptor subtypes in normal human pituitaries nonfunctioning pituitary adenomas and somatotropinomas and the association between dopamine and somatostatin receptors with clinical response to octreotide-LAR in acromegaly, J Clin Endocrinol Metab, 94, 1931, 10.1210/jc.2008-1826
Gadelha, 2007, Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas, Eur J Endocrinol, 156, 65, 10.1530/eje.1.02313
Lopez-Miranda, 2014, Dietary fat alters the expression of cortistatin and ghrelin systems in the PBMCs of elderly subjects: putative implications in the postprandial inflammatory response, Mol Nutr Food Res, 58, 1897, 10.1002/mnfr.201400059
Clarke, 2012, A detailed mammosphere assay protocol for the quantification of breast stem cell activity, J Mammary Gland Biol Neoplasia, 17, 111, 10.1007/s10911-012-9255-3
Eliceiri, 2012, NIH Image to ImageJ: 25 years of image analysis, Nat Methods, 9, 671, 10.1038/nmeth.2089
de Medina, 2010, Reversible Ponceau staining as a loading control alternative to actin in Western blots, Anal Biochem, 401, 318, 10.1016/j.ab.2010.02.036