The threshold of alpha-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

HB El-Serag, 2007, Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, Gastroenterology, 132, 2557, 10.1053/j.gastro.2007.04.061

SF Altekruse, 2009, Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005, Journal of clinical oncology: official journal of the American Society of Clinical Oncology, 27, 1485, 10.1200/JCO.2008.20.7753

HB El-Serag, 2011, Hepatocellular carcinoma, The New England journal of medicine, 365, 1118, 10.1056/NEJMra1001683

JM Llovet, 1999, Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials, Hepatology, 29, 62, 10.1002/hep.510290145

JM Llovet, 2000, Early diagnosis and treatment of hepatocellular carcinoma, Bailliere's best practice & research Clinical gastroenterology, 14, 991, 10.1053/bega.2000.0143

GN Ioannou, 2008, Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival, Gastroenterology, 134, 1342, 10.1053/j.gastro.2008.02.013

RT Stravitz, 2008, Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome, The American journal of medicine, 121, 119, 10.1016/j.amjmed.2007.09.020

2012, EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma, J Hepatol, 56, 908, 10.1016/j.jhep.2011.12.001

JA Marrero, 2018, Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases, Hepatology (Baltimore, Md), 68, 723, 10.1002/hep.29913

M Omata, 2010, Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma, Hepatology international, 4, 439, 10.1007/s12072-010-9165-7

M Kudo, 2011, Management of hepatocellular carcinoma in Japan: Consensus-Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version, Digestive diseases (Basel, Switzerland), 29, 339, 10.1159/000327577

IF Ciernik, 1993, Risk factors for hepatocellular carcinoma in patients with chronic liver diseases, The New England journal of medicine, 329, 1897

AM Di Bisceglie, 2005, Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial, J Hepatol, 43, 434, 10.1016/j.jhep.2005.03.019

T Yamashita, 2008, EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma, Cancer research, 68, 1451, 10.1158/0008-5472.CAN-07-6013

A Villanueva, 2010, Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy, Annual review of medicinePubMed Central PMCID, 61, 317

Y Hoshida, 2009, Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma, Cancer research, 69, 7385, 10.1158/0008-5472.CAN-09-1089

F Trevisani, 2001, Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status, J Hepatol, 34, 570, 10.1016/S0168-8278(00)00053-2

Weidao Li, 2000, Revision of the criteria for diagnosis and staging of primary liver cancer, Chinese journal of general surgery, 46

Jianye Xu, 2009, Systematic evaluation of the accuracy of alpha-fetoprotein in diagnosis of primary liver cancer, Chinese journal of evidence-based medicine, 9, 525

Jianhuai Zhang, 2002, Diagnosis and analysis of 424 cases of hepatocellular carcinoma with low concentration of alpha-fetoprotein, Chinese journal of general surgery, 36

AG Singal, 2012, Effectiveness of hepatocellular carcinoma surveillance in patients with cirrhosis, Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 21, 793, 10.1158/1055-9965.EPI-11-1005

JA Marrero, 2011, Alpha-fetoprotein should be included in the hepatocellular carcinoma surveillance guidelines of the American Association for the Study of Liver Diseases, Hepatology, 53, 1060, 10.1002/hep.24033

FA Lederle, 2012, Screening for liver cancer: the rush to judgment, Annals of internal medicine, 156, 387, 10.7326/0003-4819-156-5-201203060-00012

K Tzartzeva, 2018, Testing for AFP in combination with ultrasound improves early liver cancer detection, Expert review of gastroenterology & hepatology, 12, 947, 10.1080/17474124.2018.1512855

JK Heimbach, 2018, AASLD guidelines for the treatment of hepatocellular carcinoma, Hepatology (Baltimore, Md), 67, 358, 10.1002/hep.29086

2018, EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma, J Hepatol, 69, 182, 10.1016/j.jhep.2018.03.019

DF Stroup, 2000, Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group, Jama, 283, 2008, 10.1001/jama.283.15.2008

AC Tricco, 2018, PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation, Annals of internal medicine, 169, 467, 10.7326/M18-0850

PF Whiting, 2011, QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies, Annals of internal medicine, 155, 529, 10.7326/0003-4819-155-8-201110180-00009

MA King, 1989, A comparison between des-gamma-carboxy prothrombin and alpha-fetoprotein as markers of hepatocellular carcinoma in southern African blacks, Journal of gastroenterology and hepatology, 4, 17, 10.1111/j.1440-1746.1989.tb00802.x

Y Takikawa, 1992, Plasma abnormal prothrombin (PIVKA-II): a new and reliable marker for the detection of hepatocellular carcinoma, Journal of gastroenterology and hepatology, 7, 1, 10.1111/j.1440-1746.1992.tb00925.x

S Fujiyama, 1992, Determination of optimum cutoff levels of plasma des-gamma-carboxy prothrombin and serum alpha-fetoprotein for the diagnosis of hepatocellular carcinoma using receiver operating characteristic curves, Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine, 13, 316, 10.1159/000217781

T Suehiro, 1994, Protein induced by vitamin K absence or antagonist II as a prognostic marker in hepatocellular carcinoma. Comparison with alpha-fetoprotein, Cancer, 73, 2464, 10.1002/1097-0142(19940515)73:10<2464::AID-CNCR2820731004>3.0.CO;2-9

GL Grazi, 1995, The role of tumor markers in the diagnosis of hepatocellular carcinoma, with special reference to the des-gamma-carboxy prothrombin, Liver transplantation and surgery: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1, 249, 10.1002/lt.500010410

F Nomura, 1999, Serum des-gamma-carboxy prothrombin levels determined by a new generation of sensitive immunoassays in patients with small-sized hepatocellular carcinoma, The American journal of gastroenterology, 94, 650, 10.1111/j.1572-0241.1999.00930.x

T Sassa, 1999, Clinical utility of simultaneous measurement of serum high-sensitivity des-gamma-carboxy prothrombin and Lens culinaris agglutinin A-reactive alpha-fetoprotein in patients with small hepatocellular carcinoma, European journal of gastroenterology & hepatology, 11, 1387, 10.1097/00042737-199912000-00008

M Ishii, 2000, Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma. South Tohoku District Study Group, The American journal of gastroenterology, 95, 1036

R Cui, 2002, Usefulness of determining a protein induced by vitamin K absence in detection of hepatocellular carcinoma, Chinese medical journal, 115, 42

A Shimizu, 2002, Sequential fluctuation pattern of serum des-gamma-carboxy prothrombin levels detected by high-sensitive electrochemiluminescence system as an early predictive marker for hepatocellular carcinoma in patients with cirrhosis, International journal of molecular medicine, 9, 245

R Cui, 2003, Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein, British journal of cancer, 88, 1878, 10.1038/sj.bjc.6601018

JA Marrero, 2003, Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients, Hepatology (Baltimore, Md), 37, 1114, 10.1053/jhep.2003.50195

JA Marrero, 2005, GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma, J Hepatol, 43, 1007, 10.1016/j.jhep.2005.05.028

CS Wang, 2005, Usefulness of serum des-gamma-carboxy prothrombin in detection of hepatocellular carcinoma, World journal of gastroenterology, 11, 6115, 10.3748/wjg.v11.i39.6115

J Kim, 2006, Elevated plasma osteopontin levels in patients with hepatocellular carcinoma, The American journal of gastroenterology, 101, 2051, 10.1111/j.1572-0241.2006.00679.x

ML Volk, 2007, Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: a comparison of AFP, DCP, and AFP-L3, Cancer biomarkers: section A of Disease markers, 3, 79, 10.3233/CBM-2007-3202

FA Durazo, 2008, Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma, Journal of gastroenterology and hepatology, 23, 1541, 10.1111/j.1440-1746.2008.05395.x

L Beneduce, 2008, Tumour-specific induction of immune complexes: DCP-IgM in hepatocellular carcinoma, European journal of clinical investigation, 38, 571, 10.1111/j.1365-2362.2008.01985.x

M Wang, 2009, Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma, Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18, 1914, 10.1158/1055-9965.EPI-08-0980

JS Hu, 2010, GP73, a resident Golgi glycoprotein, is sensibility and specificity for hepatocellular carcinoma of diagnosis in a hepatitis B-endemic Asian population, Medical oncology (Northwood, London, England), 27, 339, 10.1007/s12032-009-9215-y

JA Marrero, 2009, Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma, Gastroenterology, 137, 110, 10.1053/j.gastro.2009.04.005

YJ Yoon, 2009, Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection, Scandinavian journal of gastroenterology, 44, 861, 10.1080/00365520902903034

RK Sterling, 2009, Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 7, 104, 10.1016/j.cgh.2008.08.041

YH Baek, 2009, Diagnostic role and correlation with staging systems of PIVKA-II compared with AFP, Hepato-gastroenterology, 56, 763

K Yamamoto, 2010, AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC, Journal of gastroenterology, 45, 1272, 10.1007/s00535-010-0278-5

Y Mao, 2010, Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma, Gut, 59, 1687, 10.1136/gut.2010.214916

H Ozkan, 2011, Diagnostic and prognostic validity of Golgi protein 73 in hepatocellular carcinoma, Digestion, 83, 83, 10.1159/000320379

SS El-Din Bessa, 2010, Clinical significance of plasma osteopontin level in Egyptian patients with hepatitis C virus-related hepatocellular carcinoma, Archives of medical research, 41, 541, 10.1016/j.arcmed.2010.10.007

B Sharma, 2010, Clinical utility of prothrombin induced by vitamin K absence in the detection of hepatocellular carcinoma in Indian population, Hepatology international, 4, 569, 10.1007/s12072-010-9186-2

H Ishida, 2010, [Evaluation of diagnostic performance of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) for HCV related hepatocellular carcinoma developed after long-term follow up], Rinsho byori The Japanese journal of clinical pathology, 58, 1065

L Tian, 2011, Serological AFP/Golgi protein 73 could be a new diagnostic parameter of hepatic diseases, International journal of cancer, 129, 1923, 10.1002/ijc.25838

Y Shi, 2011, A study of diagnostic value of golgi protein GP73 and its genetic assay in primary hepatic carcinoma, Technology in cancer research & treatment, 10, 287, 10.7785/tcrt.2012.500205

MA Abu El Makarem, 2011, Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma, Annals of hepatology, 10, 296, 10.1016/S1665-2681(19)31541-8

K Morota, 2011, A comparative evaluation of Golgi protein-73, fucosylated hemopexin, alpha-fetoprotein, and PIVKA-II in the serum of patients with chronic hepatitis, cirrhosis, and hepatocellular carcinoma, Clin Chem Lab Med, 49, 711, 10.1515/CCLM.2011.097

M Salem, 2013, Clinical Significance of Plasma Osteopontin Level as a Biomarker of Hepatocellular Carcinoma, Gastroenterology research, 6, 191

S Shang, 2012, Identification of osteopontin as a novel marker for early hepatocellular carcinoma, Hepatology (Baltimore, Md), 55, 483, 10.1002/hep.24703

L Yang, 2013, Secretory/releasing proteome-based identification of plasma biomarkers in HBV-associated hepatocellular carcinoma, Science China Life sciences, 56, 638, 10.1007/s11427-013-4497-x

JY Choi, 2013, Diagnostic value of AFP-L3 and PIVKA-II in hepatocellular carcinoma according to total-AFP, World journal of gastroenterology, 19, 339, 10.3748/wjg.v19.i3.339

JM Ertle, 2013, A combination of alpha-fetoprotein and des-gamma-carboxy prothrombin is superior in detection of hepatocellular carcinoma, Digestion, 87, 121, 10.1159/000346080

JB Xu, 2014, Value of alpha-fetoprotein and clinical characteristics in patients with liver neoplasm, Neoplasma, 61, 218, 10.4149/neo_2014_028

SL Chan, 2014, Performance of serum alpha-fetoprotein levels in the diagnosis of hepatocellular carcinoma in patients with a hepatic mass, HPB: the official journal of the International Hepato Pancreato Biliary Association, 16, 366, 10.1111/hpb.12146

P Gopal, 2014, Factors that affect accuracy of alpha-fetoprotein test in detection of hepatocellular carcinoma in patients with cirrhosis, Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association, 12, 870, 10.1016/j.cgh.2013.09.053

HJ Lee, 2014, Clinical utility of plasma glypican-3 and osteopontin as biomarkers of hepatocellular carcinoma, Gut and liver, 8, 177, 10.5009/gnl.2014.8.2.177

MI Nabih, 2014, Significance of plasma osteopontin in diagnosis of hepatitis C virus-related hepatocellular carcinoma, Arab journal of gastroenterology: the official publication of the Pan-Arab Association of Gastroenterology, 15, 103, 10.1016/j.ajg.2014.08.002

P Song, 2014, Clinical utility of simultaneous measurement of alpha-fetoprotein and des-gamma-carboxy prothrombin for diagnosis of patients with hepatocellular carcinoma in China: A multi-center case-controlled study of 1,153 subjects, Bioscience trends, 8, 266, 10.5582/bst.2014.01116

AN da Costa, 2015, Osteopontin and latent-TGF beta binding-protein 2 as potential diagnostic markers for HBV-related hepatocellular carcinoma, International journal of cancer, 136, 172, 10.1002/ijc.28953

N Pote, 2015, Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion, J Hepatol, 62, 848, 10.1016/j.jhep.2014.11.005

TS Chang, 2015, Alpha-Fetoprotein Measurement Benefits Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis, The American journal of gastroenterology, 110, 836, 10.1038/ajg.2015.100

RA Gani, 2015, Performance of Alpha Fetoprotein in Combination with Alpha-1-acid Glycoprotein for Diagnosis of Hepatocellular Carcinoma Among Liver Cirrhosis Patients, Acta medica Indonesiana, 47, 216

N Chimparlee, 2015, Diagnostic and Prognostic Roles of Serum Osteopontin and Osteopontin Promoter Polymorphisms in Hepatitis B-related Hepatocellular Carcinoma, Asian Pacific journal of cancer prevention: APJCP, 16, 7211, 10.7314/APJCP.2015.16.16.7211

SA Fouad, 2015, Plasma Osteopontin Level in Chronic Liver Disease and Hepatocellular Carcinoma, Hepatitis monthly, 15, e30753, 10.5812/hepatmon.30753

T Ge, 2015, Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma, Medical oncology (Northwood, London, England), 32, 59, 10.1007/s12032-014-0367-z

R Yu, 2015, Performance of Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) for Hepatocellular Carcinoma Screening in Chinese Population, Hepatitis monthly, 15, e28806

ES Jang, 2016, Diagnostic Performance of Alpha-Fetoprotein, Protein Induced by Vitamin K Absence, Osteopontin, Dickkopf-1 and Its Combinations for Hepatocellular Carcinoma, PloS one, 11, e0151069, 10.1371/journal.pone.0151069

R Vongsuvanh, 2016, Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma, PloS one, 11, e0155800, 10.1371/journal.pone.0155800

J Ji, 2016, Diagnostic Evaluation of Des-Gamma-Carboxy Prothrombin versus alpha-Fetoprotein for Hepatitis B Virus-Related Hepatocellular Carcinoma in China: A Large-Scale, Multicentre Study, PloS one, 11, e0153227, 10.1371/journal.pone.0153227

DG Ahn, 2016, Feasibility of alpha-fetoprotein as a diagnostic tool for hepatocellular carcinoma in Korea, The Korean journal of internal medicine, 31, 46, 10.3904/kjim.2016.31.1.46

TS Lim, 2016, Combined use of AFP, PIVKA-II, and AFP-L3 as tumor markers enhances diagnostic accuracy for hepatocellular carcinoma in cirrhotic patients, Scandinavian journal of gastroenterology, 51, 344, 10.3109/00365521.2015.1082190

DB Petitti, 2001, Approaches to heterogeneity in meta-analysis, Statistics in medicine, 20, 3625, 10.1002/sim.1091

YR Liu, 2014, Alpha-fetoprotein level as a biomarker of liver fibrosis status: a cross-sectional study of 619 consecutive patients with chronic hepatitis B, BMC gastroenterology, 14, 145, 10.1186/1471-230X-14-145

Xiaoman Zhang, 2017, Expression characteristics of serum alpha-fetoprotein, interleukin-6 and golgi body protein 73 in liver diseases and their diagnostic value in hepatocellular carcinoma, Chinese journal of experimental and clinical infectious diseases (electronic version), 11, 339

D Reim, 2017, Alpha-fetoprotein is a significant prognostic factor for gastric cancer: Results from a propensity score matching analysis after curative resection, European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 43, 1542, 10.1016/j.ejso.2017.04.005

Ningning Lu, 2017, Serum AFP vitamin K deficiency or antagonist Ⅱ induced proteins in the diagnosis of hepatocellular carcinoma (HCC) pathological application value, Journal of clinical hepatobiliary disease, 33, 2162

Wei Li, 2007, Clinical application and laboratory evaluation of alpha-fetoprotein, Clinical misdiagnosis and mistreatment, 97

Zhao Li, 2017, Interpretation of primary liver cancer diagnosis and treatment norms (2017 edition), Journal of clinical hepatobiliary disease, 33, 1655

A Cedrone, 2000, Utility of alpha-fetoprotein (AFP) in the screening of patients with virus-related chronic liver disease: does different viral etiology influence AFP levels in HCC?, A study in 350 western patients. Hepato-gastroenterology, 47, 1654

Jianye Xu, 2009, Study on serum alpha fetoprotein in diagnosis of primary liver cancer, Chongqing medical, 38, 51

J Bruix, 2011, Management of hepatocellular carcinoma: an update, Hepatology (Baltimore, Md), 53, 1020, 10.1002/hep.24199

Qingru Li, 2016, The application value and clinical significance of tumor marker protein chip detection in the health examination of the elderly, Journal of jilin university (medical edition), 42, 535

TS Chang, 2016, Corrigendum: Alpha-Fetoprotein Measurement Benefits Hepatocellular Carcinoma Surveillance in Patients With Cirrhosis, The American journal of gastroenterology, 111, 1668, 10.1038/ajg.2016.426

Bingyan Lai, 2016, Comparison of CT and B ultrasound in the first diagnosis of primary liver cancer, Chinese journal of CT and MRI, 14, 71