The role of stearoyl-CoA desaturase in the control of metabolism

Ntambi, 1995, The regulation of stearoyl-CoA desaturase (SCD), Prog. Lipid. Res., 34, 139, 10.1016/0163-7827(94)00010-J

Tocher, 1998, Recent developments in the molecular biology and biochemistry of fatty acyl desatuases, Prog. Lipid. Res., 37, 73, 10.1016/S0163-7827(98)00005-8

Miyazaki, 2001, A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis, J. Lipid. Res., 42, 1018, 10.1016/S0022-2275(20)31589-3

DeWille, 1992, Postnatal dietary fat influences mRNAS involved in myelination, Dev. Neurosci., 14, 61, 10.1159/000111648

Kim, 1999, Selective activation of phospholipase D2 by unsaturated fatty acid, FEBS Lett., 454, 42, 10.1016/S0014-5793(99)00745-0

Ntambi, 1999, Regulation of stearoyl-CoA desaturese by polyunsaturated fatty acids and cholesterol, J. Lipid. Res., 40, 1549, 10.1016/S0022-2275(20)33401-5

Obici, 2002, Central administration of oleic acid inhibits glucose production and food intake, Diabetes, 51, 271, 10.2337/diabetes.51.2.271

Nielsen, 2004, Food intake is inhibited by oral oleoylethanolamide, J. Lipid. Res., 45, 1027, 10.1194/jlr.C300008-JLR200

Roche, 1999, Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1, Diabetes, 48, 2007, 10.2337/diabetes.48.10.2007

Lee, 2002, Elevation of oleate-activated phospholipase D activity during thymic atrophy, Immunology, 107, 435, 10.1046/j.1365-2567.2002.01532.x

Listenberger, 2003, Triglyceride accumulation protects against fatty acid-induced lipotoxicity, Proc. Natl. Acad. Sci. USA, 100, 3077, 10.1073/pnas.0630588100

Hardy, 2003, Saturated fatty acids induced apoptosis in MDA-MB-231 breast cancer cells: a role for cardiolipin, J. Biol. Chem., 278, 31,861, 10.1074/jbc.M300190200

Hardy, 2000, Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects, Cancer Res., 60, 6353

Ntambi, 2002, Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity, Proc. Natl. Acad. Sci. USA, 99, 11,482, 10.1073/pnas.132384699

Rahman, 2003, Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle, Proc. Natl. Acad. Sci. USA, 100, 11,110, 10.1073/pnas.1934571100

Rahman, 2005, Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue, Am. J. Physiol. Endocrinol. Metab., 288, E381, 10.1152/ajpendo.00314.2004

Dobrzyn, 2004, The role of stearoyl-CoA desaturase in body weight regulation, Trends Cardiovasc. Med., 14, 77, 10.1016/j.tcm.2003.12.005

Cohen, 2002, Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss, Science, 297, 240, 10.1126/science.1071527

Ntambi, 2003, Recent insights into stearoyl-CoA desaturase-1, Curr. Opin. Lipidol., 14, 255, 10.1097/00041433-200306000-00005

Ntambi, 2004, Regulation of stearoyl-CoA desaturases and role in metabolism, Prog. Lipid. Res., 43, 91, 10.1016/S0163-7827(03)00039-0

Miyazaki, 2000, The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1, J. Biol. Chem., 275, 30,132, 10.1074/jbc.M005488200

Miyazaki, 2004, Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms, J. Biol. Chem., 279, 25,164, 10.1074/jbc.M402781200

Miyazaki, 2004, Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-{alpha}, J. Biol. Chem., 279, 35,017, 10.1074/jbc.M405327200

Dobrzyn, 2004, Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver, Proc. Natl. Acad. Sci. USA, 101, 6409, 10.1073/pnas.0401627101

Hardie, 2002, Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase, Biochem. Soc. Trans., 30, 1064, 10.1042/bst0301064

McGarry, 1977, A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis, J. Clin. Invest., 60, 265, 10.1172/JCI108764

Brown, 1998, Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake, Nutr. Rev., 56, S1, 10.1111/j.1753-4887.1998.tb01680.x

Tanaka, 2003, Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome, Proc. Natl. Acad. Sci. USA, 100, 15924, 10.1073/pnas.0306981100

Wang, 2003, Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity, Cell, 113, 159, 10.1016/S0092-8674(03)00269-1

Dobrzyn, 2005, Stearoyl-CoA desaturase 1deficiency reduces ceramide synthesis by down-regulating serine palmitoyltransferase and increasing b-oxidation in skeletal muscle, Am. J. Physiol. Endocrinol. Metab., 288, E599, 10.1152/ajpendo.00439.2004

Minokoshi, 2002, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, Nature, 415, 339, 10.1038/415339a

Kakuma, 2002, Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase, Biochem. Biophys. Res. Commun., 297, 1259, 10.1016/S0006-291X(02)02375-6

Shulman, 2000, Cellular mechanisms of insulin resistance, J. Clin. Invest., 106, 171, 10.1172/JCI10583

Unger, 2002, Lipotoxic diseases, Annu. Rev. Med., 53, 319, 10.1146/annurev.med.53.082901.104057

Lee, 2004, Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis, but causes hypothermia in cold environment, J. Lipid. Res., 45, 1674, 10.1194/jlr.M400039-JLR200

Ogden, 2002, Prevalence and trends in overweight among US children and adolescents, J. Am. Med. Assoc., 288, 1728, 10.1001/jama.288.14.1728

Flegal, 2002, Prevalence and trends in obesity among US adults, J. Am. Med. Assoc., 288, 1723, 10.1001/jama.288.14.1723

Gomez, 2002, Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA, Biochemistry, 41, 5473, 10.1021/bi012177r

Flegal, 2002, Prevalence and trends in obesity among US adults, J. Am. Med. Assoc., 288, 1723, 10.1001/jama.288.14.1723

Harris, 1988, Body mass index and mortality among nonsmoking older persons. The Framingham heart study, J. Am. Med. Assoc., 259, 1520, 10.1001/jama.1988.03720100038035

Kopelman, 2000, Obesity as a medical problem, Nature, 404, 635, 10.1038/35007508

Tuomilehto, 2001, Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance, N. Engl. J. Med., 344, 1343, 10.1056/NEJM200105033441801

Knowler, 2002, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N. Engl. J. Med., 346, 393, 10.1056/NEJMoa012512

Miyazaki, 2003, Role of stearoyl-coenzyme A desaturase in lipid metabolism, Prostaglandins Leukot. Essent. Fatty Acids, 68, 113, 10.1016/S0952-3278(02)00261-2

Dobrzyn, 2005, Stearoyl-CoA desaturase as a new drug target for obesity treatment, Obes. Rev., 6, 169, 10.1111/j.1467-789X.2005.00177.x

Bellentani, 2000, Prevalence of and risk factors for hepatic steatosis in Northern Italy, Ann. Intern. Med., 132, 112, 10.7326/0003-4819-132-2-200001180-00004

Fromenty, 2004, The ins and outs of mitochondrial dysfunction in NASH, Diabetes Metab., 30, 121, 10.1016/S1262-3636(07)70098-8

Festi, 2004, Hepatic steatosis in obese patients: clinical aspects and prognostic significance, Obes. Rev., 5, 27, 10.1111/j.1467-789X.2004.00126.x

Araya, 2004, Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease, Clin. Sci. (London), 106, 635, 10.1042/CS20030326

Shimomura, 1998, Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver, J. Biol. Chem., 273, 35,299, 10.1074/jbc.273.52.35299

Attie, 2002, Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia, J. Lipid. Res., 43, 1899, 10.1194/jlr.M200189-JLR200

Buhman, 2000, Mammalian acyl-CoA: cholesterol acyltransferases, Biochim. Biophys. Acta., 1529, 142, 10.1016/S1388-1981(00)00144-X

Cohen, 2003, Stearoyl-CoA desaturase-1 and the metabolic syndrome, Curr. Drug. Targets. Immune. Endocr. Metabol. Disord., 3, 271, 10.2174/1568008033340117

Sun, 2003, Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure, J. Biol. Chem., 278, 5813, 10.1074/jbc.M208687200

Chen, 2001, Turning WAT into BAT gets rid of fat, Nat. Med., 7, 1102, 10.1038/nm1001-1102

Maffei, 1995, Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects, Nat. Med., 1, 1155, 10.1038/nm1195-1155

Guzman, 2004, Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha), J. Biol. Chem., 279, 27,849, 10.1074/jbc.M404087200