The role of P2X7 receptors in tissue fibrosis: a brief review
Tóm tắt
Many previous studies have demonstrated that P2X7 receptors (P2X7Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X7R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X7R and summarize the current knowledge about the putative role of the P2X7R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.
Tài liệu tham khảo
citation_journal_title=Sci Signal; citation_title=Basal release of ATP: an autocrine-paracrine mechanism for cell regulation; citation_author=R Corriden, PA Insel; citation_volume=3; citation_issue=104; citation_publication_date=2010; citation_pages=re1; citation_doi=10.1126/scisignal.3104re1; citation_id=CR1
citation_journal_title=Pharmacol Rev; citation_title=Purinergic nerves; citation_author=G Burnstock; citation_volume=24; citation_publication_date=1972; citation_pages=509-581; citation_id=CR2
citation_journal_title=Pharmacol Ther; citation_title=Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation; citation_author=MJ Bours, EL Swennen, F Virgilio, BN Cronstein, PC Dagnelie; citation_volume=112; citation_issue=2; citation_publication_date=2006; citation_pages=358-404; citation_doi=10.1016/j.pharmthera.2005.04.013; citation_id=CR3
citation_journal_title=Front Biosci (Schol Ed); citation_title=P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation; citation_author=MJ Bours, PC Dagnelie, AL Giuliani, A Wesselius, F Virgilio; citation_volume=3; citation_publication_date=2011; citation_pages=1443-1456; citation_doi=10.2741/235; citation_id=CR4
citation_journal_title=Biomedical J; citation_title=The role of p2x7 receptor in infectious inflammatory diseases and the influence of ecto-nucleotidases; citation_author=AC Morandini, LE Savio, R Coutinho-Silva; citation_volume=37; citation_issue=4; citation_publication_date=2014; citation_pages=169-177; citation_doi=10.4103/2319-4170.127803; citation_id=CR5
citation_journal_title=Crit Rev Biochem Mol Biol; citation_title=Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities; citation_author=GG Yegutkin; citation_volume=49; citation_publication_date=2014; citation_pages=473-497; citation_doi=10.3109/10409238.2014.953627; citation_id=CR6
citation_journal_title=Adv Pharmacol; citation_title=Impact of ectoenzymes on p2 and p1 receptor signaling; citation_author=F Kukulski, SA Lévesque, J Sévigny; citation_volume=61; citation_publication_date=2011; citation_pages=263-299; citation_doi=10.1016/B978-0-12-385526-8.00009-6; citation_id=CR7
citation_journal_title=Biol Rep; citation_title=Adenosine receptors and fibrosis: a translational review. F1000; citation_author=BN Cronstein; citation_volume=3; citation_publication_date=2011; citation_pages=21; citation_id=CR8
citation_journal_title=J Mol Med (Berl); citation_title=Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system; citation_author=PE Lazzerini, M Natale, E Gianchecchi; citation_volume=90; citation_issue=3; citation_publication_date=2012; citation_pages=331-342; citation_doi=10.1007/s00109-011-0824-5; citation_id=CR9
citation_journal_title=Pharmacol Rev; citation_title=Receptors for purines and pyrimidines; citation_author=V Ralevic, G Burnstock; citation_volume=50; citation_publication_date=1998; citation_pages=413-492; citation_id=CR10
citation_journal_title=Eur J Neurosci; citation_title=P2X receptors: an emerging channel family; citation_author=G Buell, G Collo, F Rassendren; citation_volume=8; citation_issue=10; citation_publication_date=1996; citation_pages=2221-2228; citation_doi=10.1111/j.1460-9568.1996.tb00745.x; citation_id=CR11
citation_journal_title=J Physiol; citation_title=Ionic permeability of, and divalent cation effects on, two ATP- gated cation channels (P2X receptors) expressed in mammalian cells; citation_author=RJ Evans, C Lewis, C Virginio; citation_volume=497; citation_issue=Pt 2; citation_publication_date=1996; citation_pages=413-422; citation_doi=10.1113/jphysiol.1996.sp021777; citation_id=CR12
citation_journal_title=Cell Mol Life Sci; citation_title=Purine and pyrimidine receptors; citation_author=G Burnstock; citation_volume=64; citation_publication_date=2007; citation_pages=1471-1483; citation_doi=10.1007/s00018-007-6497-0; citation_id=CR13
citation_journal_title=Int Rev Cytol; citation_title=Cellular distribution and functions of P2 receptor subtypes in different systems; citation_author=G Burnstock, GE Knight; citation_volume=240; citation_publication_date=2004; citation_pages=31-304; citation_doi=10.1016/S0074-7696(04)40002-3; citation_id=CR14
citation_journal_title=Pharmacol Rev; citation_title=Pathophysiology and therapeutic potential of purinergic signaling; citation_author=G Burnstock; citation_volume=58; citation_issue=1; citation_publication_date=2006; citation_pages=58-86; citation_doi=10.1124/pr.58.1.5; citation_id=CR15
citation_journal_title=J Immunol; citation_title=The P2X7 receptor: a key player in IL-1 processing and release; citation_author=D Ferrari, C Pizzirani, E Adinolfi; citation_volume=176; citation_issue=7; citation_publication_date=2006; citation_pages=3877-3883; citation_doi=10.4049/jimmunol.176.7.3877; citation_id=CR16
citation_journal_title=Purinergic Signal; citation_title=Regulation of P2X7 gene transcription; citation_author=L Zhou, L Luo, X Qi, X Li, GI Gorodeski; citation_volume=5; citation_issue=3; citation_publication_date=2009; citation_pages=409-426; citation_doi=10.1007/s11302-009-9167-x; citation_id=CR17
citation_journal_title=Receptors Channels; citation_title=Gene structure and chromosomal localization of the human P2X7 receptor; citation_author=GN Buell, F Talabot, A Gos, J Lorenz, E Lai, MA Morris, SE Antonarakis; citation_volume=5; citation_issue=6; citation_publication_date=1998; citation_pages=347-354; citation_id=CR18
citation_journal_title=Physiol Rev; citation_title=Molecular physiology of P2X receptors; citation_author=RA North; citation_volume=82; citation_issue=4; citation_publication_date=2002; citation_pages=1013-1067; citation_doi=10.1152/physrev.00015.2002; citation_id=CR19
citation_journal_title=Blood; citation_title=Blockade of human P2X7 receptor function with a monoclonal anti body; citation_author=G Buell, IP Chessell, AD Michel; citation_volume=92; citation_issue=10; citation_publication_date=1998; citation_pages=3521-3528; citation_id=CR20
citation_journal_title=J Immunol; citation_title=Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide; citation_author=LC Denlinger, PL Fisette, JA Sommer; citation_volume=167; citation_issue=4; citation_publication_date=2001; citation_pages=1871-1876; citation_doi=10.4049/jimmunol.167.4.1871; citation_id=CR21
citation_journal_title=J Biol Chem; citation_title=P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region; citation_author=ML Smart, B Gu, RG Panchal, J Wiley, B Cromer, DA Williams, S Petrou; citation_volume=278; citation_issue=10; citation_publication_date=2003; citation_pages=8853-8860; citation_doi=10.1074/jbc.M211094200; citation_id=CR22
citation_journal_title=Biochem Bio phys Res Commun 19;; citation_title=Homotrimeric complexes are the dominant assembly state of native P2X7 subunits; citation_author=A Nicke; citation_volume=377; citation_issue=3; citation_publication_date=2008; citation_pages=803-808; citation_doi=10.1016/j.bbrc.2008.10.042; citation_id=CR23
citation_journal_title=Eur J Immunol; citation_title=The purinergic P2 × 7 receptor is expressed on monocytes in Behçet’s disease and is modulated by TNF-α; citation_author=M Castrichini, PE Lazzerini, A Gamberucci; citation_volume=44; citation_issue=1; citation_publication_date=2014; citation_pages=227-238; citation_doi=10.1002/eji.201343353; citation_id=CR24
citation_journal_title=Neuropharmacology; citation_title=Tissue distribution of the P2X7 receptor; citation_author=G Collo, S Neidhart, E Kawashima, M Kosco-Vilbois, RA North, G Buell; citation_volume=36; citation_issue=9; citation_publication_date=1997; citation_pages=1277-1283; citation_doi=10.1016/S0028-3908(97)00140-8; citation_id=CR25
citation_journal_title=J Neurosci; citation_title=Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems; citation_author=SA Deuchars, L Atkinson, RE Brooke; citation_volume=21; citation_issue=18; citation_publication_date=2001; citation_pages=7143-7152; citation_id=CR26
citation_journal_title=J Bone Miner Res; citation_title=Expression of a P2X7 receptor by a subpopulation of human osteoblasts; citation_author=A Gartland, RA Hipskind, JA Gallagher, WB Bowler; citation_volume=16; citation_issue=5; citation_publication_date=2001; citation_pages=846-856; citation_doi=10.1359/jbmr.2001.16.5.846; citation_id=CR27
citation_journal_title=Cell Tissue Res; citation_title=Localization of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia; citation_author=U Gröschel-Stewart, M Bardini, T Robson, G Burnstock; citation_volume=296; citation_issue=3; citation_publication_date=1999; citation_pages=599-605; citation_doi=10.1007/s004410051321; citation_id=CR28
citation_journal_title=J Cell Sci; citation_title=Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fuxes, microvesicle formation and IL-6 release; citation_author=A Solini, P Chiozzi, A Morelli, R Fellin, F Virgilio; citation_volume=112; citation_publication_date=1999; citation_pages=297-305; citation_id=CR29
citation_journal_title=J Mol Med; citation_title=Human rheumatoid synoviocytes express functional P2X7 receptors; citation_author=F Caporali, PL Capecchi, A Gamberucci; citation_volume=86; citation_issue=8; citation_publication_date=2008; citation_pages=937-949; citation_doi=10.1007/s00109-008-0365-8; citation_id=CR30
citation_journal_title=Expert Opin Investig Drugs; citation_title=A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases; citation_author=N Arulkumaran, RJ Unwin, FW Tam; citation_volume=20; citation_issue=7; citation_publication_date=2011; citation_pages=897-915; citation_doi=10.1517/13543784.2011.578068; citation_id=CR31
citation_journal_title=Science; citation_title=The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7); citation_author=A Surprenant, F Rassendren, E Kawashima, RA North, G Buell; citation_volume=272; citation_issue=5262; citation_publication_date=1996; citation_pages=735-738; citation_doi=10.1126/science.272.5262.735; citation_id=CR32
citation_journal_title=Immunol Today; citation_title=The P2z purino receptor: an intriguing role in immunity, inflammation and cell death; citation_author=F Virgilio; citation_volume=16; citation_issue=11; citation_publication_date=1995; citation_pages=524-528; citation_doi=10.1016/0167-5699(95)80045-X; citation_id=CR33
citation_journal_title=Drug Dev Res; citation_title=Purinergic P2X7 receptor: a pivotal role in inflammation and immunomodulation; citation_author=F Virgilio, S Falzoni, C Mutini, JM Sanz, P Chiozzi; citation_volume=145; citation_publication_date=1998; citation_pages=207-213; citation_doi=10.1002/(SICI)1098-2299(199811/12)45:3/4<207::AID-DDR18>3.0.CO;2-N; citation_id=CR34
citation_journal_title=J Inflamm (Lond); citation_title=The role of the purinergic P2X7 receptor in inflammation; citation_author=MF Lister, J Sharkey, DA Sawatzky, JP Hodgkiss, DJ Davidson, AG Rossi, K Finlayson; citation_volume=16; citation_publication_date=2007; citation_pages=4-5; citation_id=CR35
citation_journal_title=Nature; citation_title=Points of control in inflammation; citation_author=C Nathan; citation_volume=420; citation_issue=6917; citation_publication_date=2002; citation_pages=846-852; citation_doi=10.1038/nature01320; citation_id=CR36
citation_journal_title=Front Cell Infect Microbiol; citation_title=Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination; citation_author=N Jounai, K Kobiyama, F Takeshita, KJ Ishii; citation_volume=2; citation_publication_date=2013; citation_pages=168; citation_doi=10.3389/fcimb.2012.00168; citation_id=CR37
citation_journal_title=J Exp Med; citation_title=Purinergic modulation of interleukin-1β release from microglial cells stimulated with bacterial endotoxin; citation_author=D Ferrari, P Chiozzi, S Falzoni, S Hanau, F Virgilio; citation_volume=185; citation_issue=3; citation_publication_date=1997; citation_pages=579-582; citation_doi=10.1084/jem.185.3.579; citation_id=CR38
citation_journal_title=Nature; citation_title=Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf; citation_author=S Mariathasan, K Newton, DM Monack, D Vucic; citation_volume=430; citation_issue=6996; citation_publication_date=2004; citation_pages=213-218; citation_doi=10.1038/nature02664; citation_id=CR39
citation_journal_title=Trends Immunol; citation_title=Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs); citation_author=A Rubartelli, MT Lotze; citation_volume=28; citation_issue=10; citation_publication_date=2007; citation_pages=429-436; citation_doi=10.1016/j.it.2007.08.004; citation_id=CR40
citation_journal_title=J Immunol; citation_title=Kinetics and mechanism of ATP-dependent IL-1β release from microglial cells; citation_author=JM Sanz, F Virgilio; citation_volume=164; citation_issue=9; citation_publication_date=2000; citation_pages=4893-4898; citation_doi=10.4049/jimmunol.164.9.4893; citation_id=CR41
citation_journal_title=Nat Rev Immunol; citation_title=Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation; citation_author=S Mariathasan, DM Monack; citation_volume=7; citation_issue=1; citation_publication_date=2007; citation_pages=31-40; citation_doi=10.1038/nri1997; citation_id=CR42
citation_journal_title=Eur Cytokine Netw; citation_title=Cytokines and human fibrosis; citation_author=EC LeRoy, MI Trojanowska, EA Smith; citation_volume=1; citation_issue=4; citation_publication_date=1990; citation_pages=215-219; citation_id=CR43
citation_journal_title=J Pathol; citation_title=Cellular and molecular mechanisms of fibrosis; citation_author=TA Wynn; citation_volume=214; citation_issue=2; citation_publication_date=2008; citation_pages=199-210; citation_doi=10.1002/path.2277; citation_id=CR44
citation_journal_title=Matrix Biol; citation_title=Fibroblast-matrix interactions in wound healing and fibrosis; citation_author=B Eckes, P Zigrino, D Kessler, O Holtkotter, P Shephard, C Mauch, T Krieg; citation_volume=19; citation_issue=4; citation_publication_date=2000; citation_pages=325-332; citation_doi=10.1016/S0945-053X(00)00077-9; citation_id=CR45
citation_journal_title=J Pathol; citation_title=The myofibroblast in wound healing and fibrocontractive diseases; citation_author=G Gabbiani; citation_volume=200; citation_issue=4; citation_publication_date=2003; citation_pages=500-503; citation_doi=10.1002/path.1427; citation_id=CR46
citation_journal_title=Nat Rev Mol Cell Biol; citation_title=Myofibroblasts and mechano-regulation of connective tissue remodelling; citation_author=JJ Tomasek, G Gabbiani, B Hinz, C Chaponnier, RA Brown; citation_volume=3; citation_issue=5; citation_publication_date=2002; citation_pages=349-363; citation_doi=10.1038/nrm809; citation_id=CR47
citation_journal_title=J Cell Biol; citation_title=Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta; citation_author=AE Postlethwaite, R Raghow, GP Stricklin, H Poppleton, JM Seyer, AH Kang; citation_volume=106; citation_issue=2; citation_publication_date=1998; citation_pages=311-318; citation_doi=10.1083/jcb.106.2.311; citation_id=CR48
citation_journal_title=Open Rheumatol J; citation_title=The role of NLRP3 inflammasome in fibrosis; citation_author=CM Artlett; citation_volume=6; citation_publication_date=2012; citation_pages=8086; citation_doi=10.2174/1874312901206010080; citation_id=CR49
citation_journal_title=N Engl J Med; citation_title=Idiopathic pulmonary fibrosis; citation_author=TJ Gross, GW Hunninghake; citation_volume=345; citation_issue=7; citation_publication_date=2001; citation_pages=517-525; citation_doi=10.1056/NEJMra003200; citation_id=CR50
citation_journal_title=Biochem Biophys Res Commun; citation_title=Identification of two novel markers for alveolar epithelial type I and II cells; citation_author=Z Chen, N Jin, T Narasaraju, J Chen, LR McFarland, M Scott, L Liu; citation_volume=319; citation_issue=3; citation_publication_date=2004; citation_pages=774-780; citation_doi=10.1016/j.bbrc.2004.05.048; citation_id=CR51
citation_journal_title=FEBS J; citation_title=Membrane compartments and purinergic signalling: occurrence and function of P2X receptors in lung; citation_author=K Barth, M Kasper; citation_volume=276; citation_issue=2; citation_publication_date=2009; citation_pages=341-353; citation_doi=10.1111/j.1742-4658.2008.06795.x; citation_id=CR52
citation_journal_title=PLoS One; citation_title=The role of purinergic signaling on deformation induced injury and repair responses of alveolar epithelial cells; citation_author=HA Belete, RD Hubmayr, S Wang, RD Singh; citation_volume=6; citation_issue=11; citation_publication_date=2011; citation_doi=10.1371/journal.pone.0027469; citation_id=CR53
citation_journal_title=Am J Respir Crit Car Med; citation_title=Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis; citation_author=N Riteau, P Gasse, L Fauconnier; citation_volume=182; citation_issue=6; citation_publication_date=2010; citation_pages=774-783; citation_doi=10.1164/rccm.201003-0359OC; citation_id=CR54
citation_journal_title=PLoS One; citation_title=P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica; citation_author=LC Monção-Ribeiro, DS Faffe, PT Santana; citation_volume=9; citation_issue=10; citation_publication_date=2014; citation_pages=e110185; citation_doi=10.1371/journal.pone.0110185; citation_id=CR55
citation_journal_title=Glia; citation_title=ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors; citation_author=WC Chen, CC Chen; citation_volume=22; citation_issue=4; citation_publication_date=1998; citation_pages=360-370; citation_doi=10.1002/(SICI)1098-1136(199804)22:4<360::AID-GLIA5>3.0.CO;2-7; citation_id=CR56
citation_journal_title=News Physiol Sci; citation_title=Purinergic signaling along the renal tubule: the current state of play; citation_author=RJ Unwin, MA Bailey, G Burnstock; citation_volume=18; citation_publication_date=2003; citation_pages=237-241; citation_id=CR57
citation_journal_title=Nephron Physiol; citation_title=P2Y receptors present in the native and isolated rat glomerulus; citation_author=MA Bailey, CM Turner, A Hus-Citharel; citation_volume=96; citation_issue=3; citation_publication_date=2004; citation_pages=p79-p90; citation_doi=10.1159/000076753; citation_id=CR58
citation_journal_title=Am J Physiol; citation_title=In vivo stimulation of apical P2 receptors in collecting ducts: evidence for inhibition of sodium reabsorption; citation_author=DG Shirley, MA Bailey, RJ Unwin; citation_volume=288; citation_publication_date=2005; citation_pages=F1243-F1248; citation_id=CR59
citation_journal_title=Kidney Int; citation_title=Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models; citation_author=O Vonend, CM Turner, CM Chan; citation_volume=66; citation_issue=1; citation_publication_date=2004; citation_pages=157-166; citation_doi=10.1111/j.1523-1755.2004.00717.x; citation_id=CR60
citation_journal_title=Kidney Int; citation_title=Purinergic modulation of mesangial extracellular matrix production: role in diabetic and other glomerular diseases; citation_author=A Solini, C Iacobini, C Ricci; citation_volume=67; citation_issue=3; citation_publication_date=2005; citation_pages=875-885; citation_doi=10.1111/j.1523-1755.2005.00152.x; citation_id=CR61
citation_journal_title=Kidney Int; citation_title=The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice; citation_author=RG Gonçalves, L Gabrich, A Rosário; citation_volume=70; citation_issue=9; citation_publication_date=2006; citation_pages=1599-1606; citation_doi=10.1038/sj.ki.5001804; citation_id=CR62
citation_journal_title=J Clin Invest; citation_title=Liver fibrosis; citation_author=R Bataller, DA Brenner; citation_volume=115; citation_issue=2; citation_publication_date=2005; citation_pages=209-218; citation_doi=10.1172/JCI24282; citation_id=CR63
citation_journal_title=Gut; citation_title=Is liver fibrosis reversible?; citation_author=RC Benyon, JP Iredale; citation_volume=46; citation_issue=4; citation_publication_date=2000; citation_pages=443-446; citation_doi=10.1136/gut.46.4.443; citation_id=CR64
citation_journal_title=Hepatology; citation_title=Apoptosis: the nexus of liver injury and fibrosis; citation_author=A Canbay, S Friedman, GJ Gores; citation_volume=39; citation_issue=2; citation_publication_date=2004; citation_pages=273-278; citation_doi=10.1002/hep.20051; citation_id=CR65
citation_journal_title=J Gastroenterol Hepatol; citation_title=Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy; citation_author=D Li, SL Friedman; citation_volume=14; citation_issue=7; citation_publication_date=1999; citation_pages=618-633; citation_doi=10.1046/j.1440-1746.1999.01928.x; citation_id=CR66
citation_journal_title=Hepatology; citation_title=Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cell: role of nitric oxide; citation_author=A Casini, E Ceni, R Salzano; citation_volume=25; citation_issue=2; citation_publication_date=1997; citation_pages=361-367; citation_doi=10.1002/hep.510250218; citation_id=CR67
citation_journal_title=Hepatology; citation_title=Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation; citation_author=O Viñas, R Bataller, P Sancho-Bru; citation_volume=38; citation_issue=4; citation_publication_date=2003; citation_pages=919-929; citation_doi=10.1002/hep.1840380418; citation_id=CR68
citation_journal_title=J Hepatol; citation_title=Liver fibrosis—from bench to bedside; citation_author=SL Friedman; citation_volume=38; citation_issue=Suppl 1; citation_publication_date=2003; citation_pages=S38-S53; citation_doi=10.1016/S0168-8278(02)00429-4; citation_id=CR69
citation_journal_title=Hepatology; citation_title=Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal; citation_author=R Bataller, KE North, DA Brenner; citation_volume=37; citation_issue=3; citation_publication_date=2003; citation_pages=493-503; citation_doi=10.1053/jhep.2003.50127; citation_id=CR70
citation_journal_title=Mol Med Rep; citation_title=P2X7 blockade attenuates mouse liver fibrosis; citation_author=C Huang, W Yu, H Cui, Y Wang, L Zhang, F Han, T Huang; citation_volume=9; citation_issue=1; citation_publication_date=2014; citation_pages=57-62; citation_id=CR71
citation_journal_title=PLoS One; citation_title=The beneficial effects of P2X7 antagonism in rats with bile duct ligation-induced cirrhosis; citation_author=H-C Tung, F-Y Lee, S-S Wang; citation_volume=10; citation_issue=5; citation_publication_date=2015; citation_pages=e0124654; citation_doi=10.1371/journal.pone.0124654; citation_id=CR72
citation_journal_title=J Endocrinol; citation_title=Purinergic signalling in the pancreas in health and disease; citation_author=G Burnstock, I Novak; citation_volume=213; citation_issue=2; citation_publication_date=2012; citation_pages=123-141; citation_doi=10.1530/JOE-11-0434; citation_id=CR73
citation_journal_title=N Engl J Med; citation_title=Chronic pancreatitis; citation_author=ML Steer, I Waxman, S Freedman; citation_volume=332; citation_issue=22; citation_publication_date=1995; citation_pages=1482-1490; citation_doi=10.1056/NEJM199506013322206; citation_id=CR74
citation_journal_title=J Gastroenterol; citation_title=Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis; citation_author=K Shimizu; citation_volume=43; citation_issue=11; citation_publication_date=2008; citation_pages=823-832; citation_doi=10.1007/s00535-008-2249-7; citation_id=CR75
citation_journal_title=Gut; citation_title=Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis; citation_author=MV Apte, PS Haber, SJ Darby, SC Rodgers, GW McCaughan, MA Korsten; citation_volume=44; citation_issue=4; citation_publication_date=1999; citation_pages=534-541; citation_doi=10.1136/gut.44.4.534; citation_id=CR76
citation_journal_title=Biochem Pharmacol; citation_title=Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase (PI3-kinase) pathway; citation_author=JA McCarroll, PA Phillips, RK Kumar, S Park, RC Pirola, JS Wilson, MV Apte; citation_volume=67; citation_publication_date=2004; citation_pages=1215-1225; citation_doi=10.1016/j.bcp.2003.11.013; citation_id=CR77
citation_journal_title=Gastroenterology; citation_title=Identification, culture and characterization of pancreatic stellate cells in rats and humans; citation_author=MG Bachem, E Schneider, H Gross, G Adler; citation_volume=115; citation_issue=2; citation_publication_date=1998; citation_pages=421-432; citation_doi=10.1016/S0016-5085(98)70209-4; citation_id=CR78
citation_journal_title=PLoS One; citation_title=The P2X7 receptor support both life and death in fibrogenic pancreatic stellate cells; citation_author=KA Haanes, A Schwab, I Novak; citation_volume=7; citation_issue=12; citation_publication_date=2012; citation_doi=10.1371/journal.pone.0051164; citation_id=CR79
citation_journal_title=Am J Physiol Gastrointest Liver Physiol; citation_title=Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease; citation_author=BM Künzli, PO Berberat, T Giese; citation_volume=292; citation_issue=1; citation_publication_date=2007; citation_pages=G223-G230; citation_doi=10.1152/ajpgi.00259.2006; citation_id=CR80
citation_journal_title=Gastroenterology; citation_title=Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice; citation_author=BM Künzli, P Nuhn, K Enjyoji; citation_volume=134; citation_issue=1; citation_publication_date=2008; citation_pages=292-305; citation_doi=10.1053/j.gastro.2007.10.030; citation_id=CR81
citation_journal_title=J Cell Physiol; citation_title=The origin of fibroblast and mechanism of cardiac fibrosis; citation_author=G Krenning, EM Zeisberg, R Kalluri; citation_volume=225; citation_issue=3; citation_publication_date=2011; citation_pages=611-637; citation_id=CR82
citation_journal_title=Circulation; citation_title=Monitoring tissue repair and fibrosis from a distance; citation_author=KT Weber; citation_volume=96; citation_issue=8; citation_publication_date=1997; citation_pages=2488-2492; citation_id=CR83
citation_journal_title=Cardiovasc Res; citation_title=Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts; citation_author=MO Gray, CS Long, JE Kalinyak, HT Li, JS Karliner; citation_volume=40; citation_issue=2; citation_publication_date=1998; citation_pages=352-363; citation_doi=10.1016/S0008-6363(98)00121-7; citation_id=CR84
citation_journal_title=J Mol Cell Cardiol; citation_title=High- but not low-molecular weight FGF-2 causes cardiac hypertrophy in vivo; possible involvement of cardiotrophin-1; citation_author=ZS Jiang, M Jeyaraman, GB Wen, RR Fandrich, IMC Dixon, PA Cattini, E Kardami; citation_volume=42; citation_issue=1; citation_publication_date=2007; citation_pages=222-233; citation_doi=10.1016/j.yjmcc.2006.09.002; citation_id=CR85
citation_journal_title=Proc Natl Acad Sci U S A; citation_title=The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse; citation_author=E Mezzaroma, S Toldo, D Farkas; citation_volume=108; citation_issue=49; citation_publication_date=2011; citation_pages=19725-19730; citation_doi=10.1073/pnas.1108586108; citation_id=CR86
citation_journal_title=Cardiovasc Res; citation_title=The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury; citation_author=Ø Sandanger, T Ranheim, LE Vinge; citation_volume=99; citation_issue=1; citation_publication_date=2013; citation_pages=164-174; citation_doi=10.1093/cvr/cvt091; citation_id=CR87