The role of NF-κB in the regulation of cell stress responses

Sen, 1986, Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism, Cell, 47, 921, 10.1016/0092-8674(86)90807-X

Baeuerle, 1996, NF-κB: ten years after, Cell, 87, 13, 10.1016/S0092-8674(00)81318-5

Rossi, 2000, Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase, Nature, 403, 103, 10.1038/47520

Chu, 2000, DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA, Cell, 103, 909, 10.1016/S0092-8674(00)00194-X

Nolan, 1992, The inhibitory ankyrin and activator Rel proteins, Curr. Opin. Genet. Dev., 2, 211, 10.1016/S0959-437X(05)80276-X

Kuriyan, 1995, Structure of the NF-kappa B transcription factor: a holistic interaction with DNA, Structure, 3, 135, 10.1016/S0969-2126(01)00143-5

Ghosh, 1995, Structure of NF-kappa B p50 homodimer bound to a kappa B site, Nature, 373, 303, 10.1038/373303a0

Gossen, 1995, Transcriptional activation by tetracycline in mammalian cells, Science, 268, 1766, 10.1126/science.7792603

Verma, 1995, Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation, Genes Dev., 9, 2723, 10.1101/gad.9.22.2723

Chen, 1995, RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation, EMBO J., 14, 1187, 10.1002/j.1460-2075.1995.tb07102.x

Traenckner, 1995, Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli, EMBO J., 14, 2876, 10.1002/j.1460-2075.1995.tb07287.x

Baeuerle, 1996, Reactive oxygen intermediates as second messengers of a general pathogen response, Pathol. Biol. (Paris), 44, 29

Baeuerle, 1994, Function and activation of NF-kappa B in the immune system, Annu. Rev. Immunol., 12, 141, 10.1146/annurev.iy.12.040194.001041

Nabel, 1993, Proposed NF-kappa B/I kappa B family nomenclature, Genes Dev., 7, 2063, 10.1101/gad.7.11.2063

Piette, 1997, Multiple redox regulation in NF-kappaB transcription factor activation, Biol. Chem., 378, 1237

Wang, 1998, Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NFkappaB activation, Int. J. Cancer, 75, 900, 10.1002/(SICI)1097-0215(19980316)75:6<900::AID-IJC13>3.0.CO;2-6

Yasumoto, 1992, Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-κB-like binding sites of the interleukin 8 gene, J. Biol. Chem., 267, 22506, 10.1016/S0021-9258(18)41701-2

Mercurio, 1999, Multiple signals converging on NF-kappaB, Curr. Opin. Cell Biol., 11, 226, 10.1016/S0955-0674(99)80030-1

Brown, 1997, Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin, Cell, 91, 845, 10.1016/S0092-8674(00)80472-9

Fried, 1996, The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction, Proc. Natl. Acad. Sci. U. S. A., 93, 13825, 10.1073/pnas.93.24.13825

DiDonato, 1997, A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB, Nature, 388, 548, 10.1038/41493

Wilson, 1999, Protein kinase C-dependent activation of NF-kappaB in enterocytes is independent of IkappaB degradation, Gastroenterology, 117, 106, 10.1016/S0016-5085(99)70556-1

Imbert, 1996, Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha, Cell, 86, 787, 10.1016/S0092-8674(00)80153-1

Osborn, 1989, Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B, Proc. Natl. Acad. Sci. U. S. A., 86, 2336, 10.1073/pnas.86.7.2336

Inoue, 2000, Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling, Exp. Cell Res., 254, 14, 10.1006/excr.1999.4733

Lee, 1997, TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation, J. Exp. Med., 185, 1275, 10.1084/jem.185.7.1275

Yin, 2001, Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice, Science, 291, 2162, 10.1126/science.1058453

Birbach, 2002, Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus, J. Biol. Chem., 277, 10842, 10.1074/jbc.M112475200

Wang, 1996, TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB, Science, 274, 784, 10.1126/science.274.5288.784

Liu, 1996, Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death, Cell, 87, 565, 10.1016/S0092-8674(00)81375-6

Beg, 1995, Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice, Genes Dev., 9, 2736, 10.1101/gad.9.22.2736

Ryan, 2000, Role of NF-kappaB in p53-mediated programmed cell death, Nature, 404, 892, 10.1038/35009130

Ravi, 2001, Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB, Nat. Cell Biol., 3, 409, 10.1038/35070096

Wiegmann, 1994, Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling, Cell, 78, 1005, 10.1016/0092-8674(94)90275-5

Hannun, 1996, Functions of ceramide in coordinating cellular responses to stress, Science, 274, 1855, 10.1126/science.274.5294.1855

Javelaud, 2001, NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B, Oncogene, 20, 4365, 10.1038/sj.onc.1204570

De Smaele, 2001, Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling, Nature, 414, 308, 10.1038/35104560

Tang, 2001, Inhibition of JNK activation through NF-kappaB target genes, Nature, 414, 313, 10.1038/35104568

Regnier, 1997, Identification and characterization of an IkappaB kinase, Cell, 90, 373, 10.1016/S0092-8674(00)80344-X

Woronicz, 1997, IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK, Science, 278, 866, 10.1126/science.278.5339.866

Mercurio, 1997, IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation, Science, 278, 860, 10.1126/science.278.5339.860

Frantz, 1994, Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B, EMBO J., 13, 861, 10.1002/j.1460-2075.1994.tb06329.x

Schreck, 1992, Dithiocarbamates as potent inhibitors of nuclear factor kappa-B activation in intact cells, J. Exp. Med., 175, 1181, 10.1084/jem.175.5.1181

Lee, 2001, Protective effects of Debo on zinc-induced apoptosis of C6 glial cells via modulation of intracellular antioxidant, reduced glutathione, Immunopharmacol. Immunotoxicol., 23, 383, 10.1081/IPH-100107338

Majumdar, 2002, Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester, J. Immunol., 168, 2644, 10.4049/jimmunol.168.6.2644

Hinz, 1999, NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition, Mol. Cell. Biol., 19, 2690, 10.1128/MCB.19.4.2690

Finco, 1997, Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation, J. Biol. Chem., 272, 24113, 10.1074/jbc.272.39.24113

Finkel, 1998, Oxygen radicals and signaling, Curr. Opin. Cell Biol., 10, 248, 10.1016/S0955-0674(98)80147-6

Rhee, 1999, A family of novel peroxidases, peroxiredoxins, BioFactors, 10, 207, 10.1002/biof.5520100218

Lander, 1997, An essential role for free radicals and derived species in signal transduction, FASEB J., 11, 118, 10.1096/fasebj.11.2.9039953

Sundaresan, 1995, Requirement for generation of H2O2 for platelet-derived growth factor signal transduction, Science, 270, 296, 10.1126/science.270.5234.296

Schreck, 1991, Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1, EMBO J., 10, 2247, 10.1002/j.1460-2075.1991.tb07761.x

Yamamoto, 1999, Sulindac inhibits activation of the NF-kappaB pathway, J. Biol. Chem., 274, 27307, 10.1074/jbc.274.38.27307

Palayoor, 1999, Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen, Oncogene, 18, 7389, 10.1038/sj.onc.1203160

Acarin, 2000, Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-kappaB in the postnatal rat brain, Neurosci. Lett., 288, 41, 10.1016/S0304-3940(00)01202-7

Staal, 1990, Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus, Proc. Natl. Acad. Sci. U. S. A., 87, 9943, 10.1073/pnas.87.24.9943

Schulze-Osthoff, 1997, Oxidative stress and signal transduction, Int. J. Vitam. Nutr. Res., 67, 336

Straus, 2000, 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway, Proc. Natl. Acad. Sci. U. S. A., 97, 4844, 10.1073/pnas.97.9.4844

Zhang, 2001, Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2, J. Immunol., 166, 7104, 10.4049/jimmunol.166.12.7104

Mohan, 1994, Induction of nuclear factor kappa B after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway, Radiat. Res., 140, 97, 10.2307/3578574

Schulze-Osthoff, 1995, Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes, Biochem. Pharmacol., 50, 735, 10.1016/0006-2952(95)02011-Z

Devary, 1993, NF-kappa B activation by ultraviolet light not dependent on a nuclear signal, Science, 261, 1442, 10.1126/science.8367725

DiDonato, 1996, Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation, Mol. Cell. Biol., 16, 1295, 10.1128/MCB.16.4.1295

Chen, 1998, Protein kinase C eta mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes, J. Biol. Chem., 273, 19424, 10.1074/jbc.273.31.19424

Chakraborti, 1998, Oxidant-mediated activation of mitogen-activated protein kinases and nuclear transcription factors in the cardiovascular system: a brief overview, Cell. Signal., 10, 675, 10.1016/S0898-6568(98)00014-X

Bradbury, 2001, Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-kappaB activation in HeLa cells occur via a mechanism involving p38 MAP kinase, Cancer Res., 61, 7689

Mansat-de Mas, 1999, Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin, Mol. Pharmacol., 56, 867, 10.1124/mol.56.5.867

Nardini, 2001, Modulation of ceramide-induced NF-kappaB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidants, Free Radic. Biol. Med., 30, 722, 10.1016/S0891-5849(00)00515-3

Li, 1998, Inhibition of AP-1 and NF-kappaB by manganese-containing superoxide dismutase in human breast cancer cells, FASEB J., 12, 1713, 10.1096/fasebj.12.15.1713

Manna, 1998, Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-B and activated protein-1, J. Biol. Chem., 273, 13245, 10.1074/jbc.273.21.13245

Xu, 1999, An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1beta, DNA Cell Biol., 18, 709, 10.1089/104454999314999

Oberley, 1986, Free radicals, cancer, and aging, 325

Oberley, 1989, Manganese superoxide dismutase in normal and transformed human embryonic lung fibroblasts, Free Radic. Biol. Med., 6, 379, 10.1016/0891-5849(89)90083-X

St Clair, 1994, Expression of manganese superoxide dismutase promotes cellular differentiation, Free Radic. Biol. Med., 16, 275, 10.1016/0891-5849(94)90153-8

Li, 1995, Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase cDNA, Oncogene, 10, 1989

Zhong, 1996, Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells, Cell Growth Differ., 7, 1175

Yan, 1996, Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV-40 transformed human lung fibroblasts, Cancer Res., 56, 2864

Epperly, 1998, Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy, Gene Ther., 5, 196, 10.1038/sj.gt.3300580

Epperly, 2000, Decreased pulmonary radiation resistance of manganese superoxide dismutase (MnSOD)-deficient mice is corrected by human manganese superoxide dismutase-plasmid/liposome (SOD2-PL) intratracheal gene therapy, Radiat. Res., 154, 365, 10.1667/0033-7587(2000)154[0365:DPRROM]2.0.CO;2

Oberley, 2001, Anticancer therapy by overexpression of superoxide dismutase, Antioxid. Redox. Signal., 3, 461, 10.1089/15230860152409095

Russell, 1995, A radioresistant variant derived from a human neuroblastoma cell line is less prone to radiation-induced apoptosis, Cancer Res., 55, 4915

Eichholtz-Wirth, 1997, Reduced expression of the ICE-related protease CPP32 is associated with radiation-induced cisplatin resistance in HeLa cells, Br. J. Cancer, 76, 1322, 10.1038/bjc.1997.555

Li, 2001, Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiation, Radiat. Res., 155, 543, 10.1667/0033-7587(2001)155[0543:EGAIMH]2.0.CO;2

Chen, 2002, Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes, Cancer Res., 62, 1213

Thanos, 1995, NF-kappa B: a lesson in family values, Cell, 80, 529, 10.1016/0092-8674(95)90506-5

Hallahan, 1998, Nuclear factor kappaB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium, Cancer Res., 58, 5484

Li, 1998, Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms, Proc. Natl. Acad. Sci. U. S. A., 95, 13012, 10.1073/pnas.95.22.13012

Beetz, 2000, NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells, Int. J. Radiat. Biol., 76, 1443, 10.1080/09553000050176207

Miyakoshi, 2000, Inhibition of I kappaB-alpha phosphorylation at serine and tyrosine acts independently on sensitization to DNA damaging agents in human glioma cells, Br. J. Cancer, 82, 28, 10.1054/bjoc.1999.0872

Lee, 1998, A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-kappaB, Oncogene, 17, 1821, 10.1038/sj.onc.1202088

Shao, 1997, Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis, J. Biol. Chem., 272, 32739, 10.1074/jbc.272.52.32739

Kato, 2000, Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB, Head Neck, 22, 748, 10.1002/1097-0347(200012)22:8<748::AID-HED2>3.0.CO;2-6

Yang, 1999, NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2, Oncogene, 18, 5177, 10.1038/sj.onc.1202904

Herscher, 1999, Principles of chemoradiation: theoretical and practical considerations, Oncology (Huntington), 13, 11

Pajonk, 1999, Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells, J. Natl. Cancer Inst., 91, 1956, 10.1093/jnci/91.22.1956

Bentires-Alj, 1999, Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs, Cancer Res., 59, 811

Keyse, 1993, The induction of gene expression in mammalian cells by radiation, Semin. Cancer Biol., 4, 119

Fornace, 1999, The complexity of radiation stress responses: analysis by informatics and functional genomics approaches, Gene Expr., 7, 387

Amundson, 1999, Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses, Oncogene, 18, 3666, 10.1038/sj.onc.1202676

Liu, 1998, Activation of Stat3 by v-Src is through a Ras-independent pathway, J. Biomed. Sci., 5, 446

Raju, 1999, NF kappa B activity and target gene expression in the rat brain after one and two exposures to ionizing radiation, Radiat. Oncol. Investig., 7, 145, 10.1002/(SICI)1520-6823(1999)7:3<145::AID-ROI2>3.0.CO;2-R

Baeuml, 1997, Ionizing radiation induces, via generation of reactive oxygen intermediates, intercellular adhesion molecule-1 (ICAM-1) gene transcription and NF kappa B-like binding activity in the ICAM-1 transcriptional regulatory region, Free Radic. Res., 27, 127, 10.3109/10715769709097846

Lin, 1993, Cytotoxicity and manganese superoxide dismutase induction by tumor necrosis factor-alpha and ionizing radiation in MCF-7 human breast carcinoma cells, Lymphokine Cytokine Res., 12, 303

Kiningham, 2001, Nuclear factor kappaB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2, Biochem. J., 353, 147, 10.1042/0264-6021:3530147

Dumic, 2000, Expression of galectin-3 in cells exposed to stress—roles of jun and NF-kappaB, Cell. Physiol. Biochem., 10, 149, 10.1159/000016345

Hallahan, 1998, X-ray-induced P-selectin localization to the lumen of tumor blood vessels, Cancer Res., 58, 5216

Iwanaga, 1998, Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells, Free Radic. Biol. Med., 24, 1256, 10.1016/S0891-5849(97)00443-7

Maity, 1994, The molecular basis for cell cycle delays following ionizing radiation: a review, Radiother. Oncol., 31, 1, 10.1016/0167-8140(94)90408-1

Almasan, 2000, Cellular commitment to radiation-induced apoptosis, Radiat. Res., 153, 347, 10.1667/0033-7587(2000)153[0347:CCTRIA]2.0.CO;2

Amundson, 1999, Induction of stress genes by low doses of gamma rays, Radiat. Res., 152, 225, 10.2307/3580321