The quinolone, flumequine, has no effect on theophylline pharmacokinetics
Tóm tắt
The kinetics of a single i. v. dose of theophylline given either alone or with flumequine was studied in eight healthy volunteers. No statistically significant differences were observed in the pharmacokinetic parameters of theophylline (volume of distribution, elimination half-life, AUC, plasma clearance) following the two treatments. Pretreatment for 5 days with oral flumequine (400 mg, three times daily) had no significant effect on the disposition of a single i. v. dose of theophylline in healthy volunteers.
Tài liệu tham khảo
Gomeni C, Gomeni R (1987) SIPHAR: an integrated computer system for statistical and pharmacokinetic data analysis. In: Serio A, O'Moore R, Tardini A, Roger FH (ed) Proceedings of the 7th international congress of medical informatics Europe 87, Rome. European Federation for Medical Informatics, Rome, pp 507–516
Jackson JE, Plachetka JR (1981) More on cimetidine-theophylline interaction. Drug Intell Clin Pharm 15: 809–810
Manfredi RL, Vesell ES (1981) Inhibition of theophylline metabolism by long-term allopurinol. Clin Pharmacol Ther 29: 224–229
Reitberg DP, Bernhard H, Schentag JJ (1981) Alteration of theophylline clearance and half-life by cimetidine in normal volunteers. Ann Intern Med 95: 582–585
Rouveix B, Pangon B (1988) Les quinolones. In: Giroud JP, Mathé G, Meyniel G (eds) Pharmacologie. Bases de la thérapeutique. Expansion Scientifique Française, Paris
Sano M, Yamamoto I, Ueda J, Yoshikawa E, Yamashina H, Goto M (1987) Comparative pharmacokinetics of theophylline following two fluoroquinolone co-administration. Eur J Clin Pharmacol 32: 431–432
Schuppan D, Harrison LI, Rohlfing SR, Miller HL, Funk ML, Hansen CS, Ober RE (1985) Plasma and urine levels of flumequine and 7-hydroxy flumequine following single and multiple oral dosing. J Antimicrob Chemother 15: 337–343
Starkey BJ, Mould GP (1984) Evaluation of a rapid high-performance liquid chromatographic method for plasma theophylline analysis and its use in therapeutic drug monitoring. Ther Drug Monit 6: 322–327
Upton RA (1991) Pharmacokinetic interactions between theophylline and other medication (part I). Clin Pharmacokinet 20: 66–80
Wijnands WJA, Vree TB, Van Herwaarden CLA (1985) Enoxacin decreases the clearance of theophylline in man. Br J Clin Pharmacol 20: 583–588
Wijnands WJA, Vree TB, Van Herwaarden CLA (1986) The influence of quinolone derivatives on theophylline clearance. Br J Clin Pharmacol 22: 677–683