The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c

Pharmacogenetics and Genomics - Tập 21 Số 12 - Trang 837-850 - 2011
Mette Marie Hougaard Christensen1,2,3,4, Charlotte Brasch‐Andersen1, Henrik Gréen1, Flemming Nielsen1, Per Damkier1, Henning Beck‐Nielsen1, Kim Brixen1
1Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.pharmacogeneticsandgenomics.com).
2e-mail: [email protected]
3fax: +45 65 91 60 89
4to Mette M.H. Christensen, MD, Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, J.B. Winsloews Vej 19, 2, Odense C DK-5000, Denmark Tel: +45 6550 3678

Tóm tắt

Từ khóa


Tài liệu tham khảo

Kahn, 2006, Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy., N Engl J Med, 355, 2427, 10.1056/NEJMoa066224

Bolen, 2007, Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus., Ann Intern Med, 147, 386, 10.7326/0003-4819-147-6-200709180-00178

Shaw, 2005, The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin., Science, 310, 1642, 10.1126/science.1120781

Shu, 2007, Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action., J Clin Invest, 117, 1422, 10.1172/JCI30558

Cusi, 1996, Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus., J Clin Endocrinol Metab, 81, 4059

Graham, 2011, Clinical pharmacokinetics of metformin., Clin Pharmacokinet, 50, 81, 10.2165/11534750-000000000-00000

Pentikainen, 1979, Pharmacokinetics of metformin after intravenous and oral administration to man., Eur J Clin Pharmacol, 16, 195, 10.1007/BF00562061

Xia, 2007, Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells., Am J Physiol Renal Physiol, 292, F682, 10.1152/ajprenal.00302.2006

Zhou, 2007, Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 family., J Biol Chem, 282, 3188, 10.1074/jbc.M609421200

Zhou, 2007, Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine., Drug Metab Dispos, 35, 1956, 10.1124/dmd.107.015495

Koepsell, 2004, Polyspecific organic cation transporters: their functions and interactions with drugs., Trends Pharmacol Sci, 25, 375, 10.1016/j.tips.2004.05.005

Koepsell, 2004, The SLC22 drug transporter family., Pflugers Arch, 447, 666, 10.1007/s00424-003-1089-9

Muller, 2005, Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)., Biochem Pharmacol, 70, 1851, 10.1016/j.bcp.2005.09.011

Koepsell, 2007, Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications., Pharm Res, 24, 1227, 10.1007/s11095-007-9254-z

Leabman, 2003, Estimating the contribution of genes and environment to variation in renal drug clearance., Pharmacogenetics, 13, 581, 10.1097/00008571-200309000-00007

Shu, 2008, Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics., Clin Pharmacol Ther, 83, 273, 10.1038/sj.clpt.6100275

Tzvetkov, 2009, The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin., Clin Pharmacol Ther, 86, 299, 10.1038/clpt.2009.92

Becker, 2009, Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus., Pharmacogenomics J, 9, 242, 10.1038/tpj.2009.15

Becker, 2009, Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study., Diabetes, 58, 745, 10.2337/db08-1028

Chen, 2009, Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin., Pharmacogenet Genomics, 19, 497, 10.1097/FPC.0b013e32832cc7e9

Song, 2008, Genetic variants of the organic cation transporter 2 influence the disposition of metformin., Clin Pharmacol Ther, 84, 559, 10.1038/clpt.2008.61

Wang, 2008, OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine., Pharmacogenet Genomics, 18, 637, 10.1097/FPC.0b013e328302cd41

Choi, 2009, Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1., Pharmacogenet Genomics, 19, 770, 10.1097/FPC.0b013e328330eeca

Kajiwara, 2009, Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity., J Hum Genet, 54, 40, 10.1038/jhg.2008.1

Ronaghi, 1998, A sequencing method based on real-time pyrophosphate., Science, 281, 363, 10.1126/science.281.5375.363

Cockcroft, 1976, Prediction of creatinine clearance from serum creatinine., Nephron, 16, 31, 10.1159/000180580

Nies, 2009, Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver., Hepatology, 50, 1227, 10.1002/hep.23103

Cho, 2011, Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants., Clin Pharmacol Ther, 89, 416, 10.1038/clpt.2010.266

Barrett, 2005, Haploview: analysis and visualization of LD and haplotype maps., Bioinformatics, 21, 263, 10.1093/bioinformatics/bth457

Stephens, 2001, A new statistical method for haplotype reconstruction from population data., Am J Hum Genet, 68, 978, 10.1086/319501

Stephens, 2005, Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation., Am J Hum Genet, 76, 449, 10.1086/428594

Shu, 2003, Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1., Proc Natl Acad Sci USA, 100, 5902, 10.1073/pnas.0730858100

Kerb, 2002, Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences., Pharmacogenetics, 12, 591, 10.1097/00008571-200211000-00002

Leabman, 2002, Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function., Pharmacogenetics, 12, 395, 10.1097/00008571-200207000-00007

Sambol, 1996, Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus., J Clin Pharmacol, 36, 1012, 10.1177/009127009603601105

Sirtori, 1978, Disposition of metformin (N,N-dimethylbiguanide) in man., Clin Pharmacol Ther, 24, 683, 10.1002/cpt1978246683

Timmins, 2005, Steady-state pharmacokinetics of a novel extended-release metformin formulation., Clin Pharmacokinet, 44, 721, 10.2165/00003088-200544070-00004

Wang, 2002, Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin., J Pharmacol Exp Ther, 302, 510, 10.1124/jpet.102.034140

Zhou, 2009, Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study., Diabetes, 58, 1434, 10.2337/db08-0896

Zolk, 2009, Current understanding of the pharmacogenomics of metformin., Clin Pharmacol Ther, 86, 595, 10.1038/clpt.2009.144

Zhou, 2011, Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes., Nat Genet, 43, 117, 10.1038/ng.735