The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Current Opinion in Pharmacology - Tập 7 Số 6 - Trang 648-652 - 2007
Xin‐Yun Lu1
1Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA

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Berton, 2006, New approaches to antidepressant drug discovery: beyond monoamines, Nat Rev Neurosci, 7, 137, 10.1038/nrn1846

Frazer, 1997, Pharmacology of antidepressants, J Clin Psychopharmacol, 17, 2S, 10.1097/00004714-199704001-00002

Elmquist, 1998, Distributions of leptin receptor mRNA isoforms in the rat brain, J Comp Neurol, 395, 535, 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2

Ahima, 2004, Leptin signaling, Physiol Behav, 81, 223, 10.1016/j.physbeh.2004.02.014

Chehab, 2000, Leptin as a regulator of adipose mass and reproduction, Trends Pharmacol Sci, 21, 309, 10.1016/S0165-6147(00)01514-5

Farr, 2006, Effects of leptin on memory processing, Peptides, 27, 1420, 10.1016/j.peptides.2005.10.006

Lu, 2006, Leptin: a potential novel antidepressant, Proc Natl Acad Sci U S A, 103, 1593, 10.1073/pnas.0508901103

Plotsky, 1998, Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis, Psychiatr Clin North Am, 21, 293, 10.1016/S0193-953X(05)70006-X

Dagogo-Jack, 1997, Robust leptin secretory responses to dexamethasone in obese subjects, J Clin Endocrinol Metab, 82, 3230

Larsson, 1996, Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women, J Clin Endocrinol Metab, 81, 4428

Miell, 1996, Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects, Horm Metab Res, 28, 704, 10.1055/s-2007-979882

Katz, 1982, Animal model of depression: pharmacological sensitivity of a hedonic deficit, Pharmacol Biochem Behav, 16, 965, 10.1016/0091-3057(82)90053-3

Willner, 2005, Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS, Neuropsychobiology, 52, 90, 10.1159/000087097

Cryan, 2005, The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice, Neurosci Biobehav Rev, 29, 571, 10.1016/j.neubiorev.2005.03.009

Cryan, 2005, Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test, Neurosci Biobehav Rev, 29, 547, 10.1016/j.neubiorev.2005.03.008

Kim, 2006, Leptin induces antidepressant-like behavioral effects and activates specific signal transduction pathways in the hippocampus and amygdala of mice, Neuropsychopharmacology, 31, S237

Hirano, 2007, Antidepressant-like effect of leptin in streptozotocin-induced diabetic mice, Pharmacol Biochem Behav, 86, 27, 10.1016/j.pbb.2006.12.003

Deuschle, 1996, Plasma leptin in depressed patients and healthy controls, Horm Metab Res, 28, 714, 10.1055/s-2007-979885

Antonijevic, 1998, Elevated nocturnal profiles of serum leptin in patients with depression, J Psychiatr Res, 32, 403, 10.1016/S0022-3956(98)00032-6

Rubin, 2002, Sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin in major depressives and matched controls, Psychiatry Res, 113, 255, 10.1016/S0165-1781(02)00263-9

Jow, 2006, Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia, J Affect Disord, 90, 21, 10.1016/j.jad.2005.09.015

Kraus, 2001, Low leptin levels but normal body mass indices in patients with depression or schizophrenia, Neuroendocrinology, 73, 243, 10.1159/000054641

Atmaca, 2002, Serum leptin and cholesterol values in suicide attempters, Neuropsychobiology, 45, 124, 10.1159/000054950

Westling, 2004, Low CSF leptin in female suicide attempters with major depression, J Affect Disord, 81, 41, 10.1016/j.jad.2003.07.002

Atmaca, 2002, Serum leptin and cholesterol levels in patients with bipolar disorder, Neuropsychobiology, 46, 176, 10.1159/000067809

Emul, 2007, Ghrelin and leptin levels in patients with obsessive-compulsive disorder, Prog Neuropsychopharmacol Biol Psychiatry, 31, 1270, 10.1016/j.pnpbp.2007.05.007

Faith, 2002, Obesity-depression associations in the population, J Psychosom Res, 53, 935, 10.1016/S0022-3999(02)00308-2

McElroy, 2004, Are mood disorders and obesity related? A review for the mental health professional, J Clin Psychiatry, 65, 634, 10.4088/JCP.v65n0507

Simon, 2006, Association between obesity and psychiatric disorders in the US adult population, Arch Gen Psychiatry, 63, 824, 10.1001/archpsyc.63.7.824

Stunkard, 2003, Depression and obesity, Biol Psychiatry, 54, 330, 10.1016/S0006-3223(03)00608-5

Heymsfield, 1999, Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial, JAMA, 282, 1568, 10.1001/jama.282.16.1568

Munzberg, 2005, Molecular and anatomical determinants of central leptin resistance, Nat Neurosci, 8, 566, 10.1038/nn1454

Finn, 2001, Serotonergic neurons are targets for leptin in the monkey, J Clin Endocrinol Metab, 86, 422

Figlewicz, 2003, Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat, Brain Res, 964, 107, 10.1016/S0006-8993(02)04087-8

Shioda, 1998, Immunohistochemical localization of leptin receptor in the rat brain, Neurosci Lett, 243, 41, 10.1016/S0304-3940(98)00082-2

Charnay, 2000, Intracerebroventricular infusion of leptin decreases serotonin transporter binding sites in the frontal cortex of the rat, Neurosci Lett, 283, 89, 10.1016/S0304-3940(00)00951-4

Collin, 2000, Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse, Brain Res Mol Brain Res, 81, 51, 10.1016/S0169-328X(00)00167-4

Calapai, 1999, Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis, J Clin Invest, 104, 975, 10.1172/JCI5867

Hastings, 2002, Influence of leptin on neurotransmitter overflow from the rat brain in vitro, Regul Pept, 103, 67, 10.1016/S0167-0115(01)00332-9

Fulton, 2006, Leptin regulation of the mesoaccumbens dopamine pathway, Neuron, 51, 811, 10.1016/j.neuron.2006.09.006

Hommel, 2006, Leptin receptor signaling in midbrain dopamine neurons regulates feeding, Neuron, 51, 801, 10.1016/j.neuron.2006.08.023

Chen, 1996, Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice, Cell, 84, 491, 10.1016/S0092-8674(00)81294-5

Chua, 1996, Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor, Science, 271, 994, 10.1126/science.271.5251.994

Stephens, 1995, The role of neuropeptide Y in the antiobesity action of the obese gene product, Nature, 377, 530, 10.1038/377530a0

Licinio, 1997, Human leptin levels are pulsatile and inversely related to pituitary-adrenal function, Nat Med, 3, 575, 10.1038/nm0597-575

Heiman, 1997, Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress, Endocrinology, 138, 3859, 10.1210/endo.138.9.5366

Oates, 2000, Chronic leptin administration in developing rats reduces stress responsiveness partly through changes in maternal behavior, Horm Behav, 37, 366, 10.1006/hbeh.2000.1578

Arvaniti, 2001, Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse, Neuroendocrinology, 73, 227, 10.1159/000054639

Huang, 1998, Effects of leptin on corticotropin-releasing factor (CRF) synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese (ob/ob) mice, Endocrinology, 139, 1524, 10.1210/endo.139.4.5889

Ahima, 1996, Role of leptin in the neuroendocrine response to fasting, Nature, 382, 250, 10.1038/382250a0

Proulx, 2001, High neonatal leptin exposure enhances brain GR expression and feedback efficacy on the adrenocortical axis of developing rats, Endocrinology, 142, 4607, 10.1210/endo.142.11.8512

Bornstein, 1997, Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly, Diabetes, 46, 1235, 10.2337/diab.46.7.1235

Glasow, 1998, Expression of Ob receptor in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptin, J Clin Endocrinol Metab, 83, 4459

Duman, 2006, A neurotrophic model for stress-related mood disorders, Biol Psychiatry, 59, 1116, 10.1016/j.biopsych.2006.02.013

Ahima, 1999, Regulation of neuronal and glial proteins by leptin: implications for brain development, Endocrinology, 140, 2755, 10.1210/endo.140.6.6774

Steppan, 1999, A role for leptin in brain development, Biochem Biophys Res Commun, 256, 600, 10.1006/bbrc.1999.0382

Vannucci, 1997, Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice, Am J Physiol, 272, E267

Matochik, 2005, Effect of leptin replacement on brain structure in genetically leptin-deficient adults, J Clin Endocrinol Metab, 90, 2851, 10.1210/jc.2004-1979

Bouret, 2004, Trophic action of leptin on hypothalamic neurons that regulate feeding, Science, 304, 108, 10.1126/science.1095004

O’Malley, 2007, Leptin promotes rapid dynamic changes in hippocampal dendritic morphology, Mol Cell Neurosci, 35, 559, 10.1016/j.mcn.2007.05.001