The effect of culture conditions and toxicity on the ames salmonella/microsome agar incorporation mutagenicity assay

Wiley - Tập 5 Số 4 - Trang 541-551 - 1983
Sonja Kazmer1, Morris Katz2, David S. Weinstein2
1Department of Toxicology and Pathology, Hoffmann‐La Roche Inc, Nutley, New Jersey
2Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, New Jersey

Tóm tắt

AbstractVarious methods were used to reconstruct an environment similar to a chemically bactericidal or bacteriostatic effect in the Ames mutagenicity assay in order to determine whether a false‐positive result could occur. Neither population reduction, sonication, nor increased histidine produced an increase of spurious revertant colonies.

Từ khóa


Tài liệu tham khảo

10.1016/0378-4274(80)90163-0

10.1016/0165-1161(75)90046-1

10.1002/em.2860010116

Fumero S, 1981, Relationship between mutagenic effect and toxic effect in the Ames test, Farmaco [Sci], 36, 867

10.1002/em.2860030406

10.1016/0165-1218(79)90085-5

10.1080/15287397809529655

10.1016/0027-5107(78)90132-X

10.1002/em.2860030102

10.1073/pnas.74.8.3555

Thông tin
Thông tin xuất bản

Wiley

Tập 5 Số 4

541-551

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