The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

Bioorganic & Medicinal Chemistry Letters - Tập 9 Số 13 - Trang 1773-1778 - 1999
Petpiboon Prasit1, Z Wang1, Christine Brideau1, Chi‐Chung Chan1, S. Charleson1, Wanda Cromlish1, Diane Ethier1, Jilly F. Evans1, A W Ford‐Hutchinson1, J. Y. GAUTHIER1, Robert J. Gordon1, Jocelyne Guay1, Michael J. Gresser1, Stacia Kargman1, Brian P. Kennedy1, Y. LEBLANC1, Serge Léger1, Joseph A. Mancini1, Gary P. O’Neill1, Marc Ouellet1, M. David Percival1, H. Perrier1, Denis Riendeau1, Ian W. Rodger1, Philip Tagari1, Michel Thérien1, Philip J. Vickers1, Elizabeth Wong1, Li-Jing Xu1, Robert N. Young1, Robert Zamboni1, S. Boyce2, N.M.J. Rupniak2, M J Forrest3, Denise M. Visco3, D Patrick4
1Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, Quebec H9R 4P8, Canada
2Merck Research Laboratories, Harlow, Essex, UK
3Merck Research Laboratories, Rahway, NJ 07065, U.S.A.
4merck Research Laboratories, West Point, PA 19486, U.S.A.

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