The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery

Journal of Surgical Oncology - Tập 104 Số 3 - Trang 323-332 - 2011
Boudewijn E. Schaafsma1, J. Sven D. Mieog1, Merlijn Hutteman1, Joost R. van der Vorst1, Peter J.K. Kuppen1, Clemens W.G.M. Löwik2, John V. Frangioni3,4, Cornelis J.�H. van de Velde1, Alexander L. Vahrmeijer1
1Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
2Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
3Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
4Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts

Tóm tắt

AbstractOptical imaging using near‐infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer‐related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non‐targeted and non‐conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence‐guided surgery. J. Surg. Oncol. 2011; 104:323–332. © 2011 Wiley‐Liss, Inc.

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