The chemistry and biological function of natural marine toxins

Chemical Record - Tập 1 Số 3 - Trang 228-242 - 2001
Takeshi Yasumoto1
1Tama Laboratory, Japan Food Research Laboratories, Tokyo.

Tóm tắt

AbstractStudies on ciguatera fish poisoning led to clarification of the absolute stereochemistry of ciguatoxin, gambierol, gambieric acids, and maitotoxin. Anisotropic NMR reagents and fluorometric chiral HPLC reagents were effectively used together with synthesis of partial structures. Structures of 16 ciguatoxin congeners were successfully elucidated by FAB/MS/MS using samples of 5 μg or less. Stereochemical assignments were also achieved on dinophysistoxin‐1, pectenotoxins, yessotoxins, polycavernoside‐A, azaspiracid, and prymnesins. The toxins possessed poly‐cyclic‐ether structures and originated from unicellular algae. Biological functions are briefly described. © 2000 John Wiley & Sons, Inc. and The Japan Chemical Journal Forum Chem Rec 1:228–242, 2001

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Tài liệu tham khảo

10.1021/cr00021a011

10.3109/15569549609064079

10.1021/ja00206a032

10.1021/ja00167a040

10.1016/S0040-4039(00)91978-6

10.1271/bbb.60.2103

10.1016/S0040-4039(97)10808-5

10.1021/ja972482t

10.1002/rcm.1290070302

10.1021/ja00095a013

Morohashi A, 1995, Tetrahedron Lett, 49, 8995, 10.1016/0040-4039(95)01969-O

10.1002/(SICI)1522-7189(199903/04)7:2<45::AID-NT34>3.0.CO;2-H

10.1002/mas.1280090202

10.1021/ja9944204

10.2216/i0031-8884-35-4-350.1

10.1016/S0040-4020(00)00753-5

10.1021/ja00054a061

10.1016/S0040-4039(97)10441-5

10.1021/ja00058a075

10.1021/ja00131a032

10.1016/0040-4039(95)02413-1

10.1002/anie.199616721

10.1002/anie.199616751

10.1021/ja961230

10.1039/a901979k

10.1002/(SICI)1522-7189(199903/04)7:2<71::AID-NT40>3.0.CO;2-0

Gusovsky F, 1990, Biochem Pharmacol, 39, 1663, 10.1016/0006-2952(90)90105-T

Sasaki K, 1998, Enantiomer, 3, 59

10.1271/bbb.61.1783

10.1246/cl.1998.653

10.1016/0040-4039(96)01580-8

10.1271/bbb.64.1761

10.1021/ja981413r

10.1021/ja00056a048

10.1021/ja982431b

10.1021/ja9534112

10.1021/ja991740e

10.1002/(SICI)1522-7189(199802)6:1<35::AID-NT7>3.0.CO;2-7

10.1007/BF00003877

10.1021/ja00131a032

10.1016/S0041-0101(98)00142-1

10.1002/19970504NT7

10.1016/0041-0101(96)00014-1

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Chemical Record

Tập 1 Số 3

228-242

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