The autoimmune basis of alopecia areata: A comprehensive review

Autoimmunity Reviews - Tập 14 Số 2 - Trang 81-89 - 2015
Naseeha Islam1, Patrick S.C. Leung1, Arthur C. Huntley2, M. Eric Gershwin1
1Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, CA 95616, United States
2Department of Dermatology, University of California, Davis, CA 95616, United States

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Parks, 2014, Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease, Int J Mol Sci, 15, 14269, 10.3390/ijms150814269

Pengo, 2013, Correct laboratory approach to APS diagnosis and monitoring, Autoimmun Rev, 12, 832, 10.1016/j.autrev.2012.11.008

Ruiz-Irastorza, 2014, Prednisone in lupus nephritis: how much is enough?, Autoimmun Rev, 13, 206, 10.1016/j.autrev.2013.10.013

Doria, 2014, Optimizing outcome in SLE: treating-to-target and definition of treatment goals, Autoimmun Rev, 13, 770, 10.1016/j.autrev.2014.01.055

Fairweather, 2004, Women and autoimmune diseases, Emerg Infect Dis, 10, 2005, 10.3201/eid1011.040367

Alkhalifah, 2010, Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis, J Am Acad Dermatol, 62, 177, 10.1016/j.jaad.2009.10.032

Madani, 2000, Alopecia areata update, J Am Acad Dermatol, 42, 549, 10.1067/mjd.2000.103909

Wade, 2002, Persistent depigmented regrowth after alopecia areata, J Am Acad Dermatol, 46, 619, 10.1067/mjd.2002.120604

Goh, 2006, Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history, J Eur Acad Dermatol Venereol, 20, 1055, 10.1111/j.1468-3083.2006.01676.x

Sperling, 1995, Histopathology of non-scarring alopecia, J Cutan Pathol, 22, 97, 10.1111/j.1600-0560.1995.tb01391.x

Gilhar, 2007, Lymphocytes, neuropeptides, and genes involved in alopecia areata, J Clin Invest, 117, 2019, 10.1172/JCI31942

MacLean, 2013, Alopecia areata: more than skin deep, Practitioner, 257, 29

Mounsey, 2009, Diagnosing and treating hair loss, Am Fam Physician, 80, 356

Vary, 2014, Common dermatologic conditions, Med Clin North Am, 98, 445, 10.1016/j.mcna.2014.01.005

Jabbari, 2013, Genetic basis of alopecia areata: a roadmap for translational research, Dermatol Clin, 31, 109, 10.1016/j.det.2012.08.014

Gregoriou, 2010, Cytokines and other mediators in alopecia areata, Mediators Inflamm, 2010, 928030, 10.1155/2010/928030

Alzolibani, 2011, Epidemiologic and genetic characteristics of alopecia areata (part 1), Acta Dermatovenerol Alp Panonica Adriat, 20, 191

Petukhova, 2010, Genome-wide association study in alopecia areata implicates both innate and adaptive immunity, Nature, 466, 113, 10.1038/nature09114

Ito, 2013, Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata, Clin Dev Immunol, 2013, 348546, 10.1155/2013/348546

Alexis, 2004, Alopecia areata: autoimmune basis of hair loss, Eur J Dermatol, 14, 364

Gilhar, 2006, Alopecia areata: a tissue specific autoimmune disease of the hair follicle, Autoimmun Rev, 5, 64, 10.1016/j.autrev.2005.07.001

Dombrowski, 2005, Alopecia areata: what to expect from current treatments, Cleve Clin J Med, 72, 758, 10.3949/ccjm.72.9.758

Tan, 2002, The pattern and profile of alopecia areata in Singapore—a study of 219 Asians, Int J Dermatol, 41, 748, 10.1046/j.1365-4362.2002.01357.x

Dudda-Subramanya, 2007, Alopecia areata: genetic complexity underlies clinical heterogeneity, Eur J Dermatol, 17, 367

Scerri, 1992, Identical twins with identical alopecia areata, J Am Acad Dermatol, 27, 766, 10.1016/S0190-9622(08)80226-5

Martinez-Mir, 2007, Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata, Am J Hum Genet, 80, 316, 10.1086/511442

McElwee, 2013, What causes alopecia areata?, Exp Dermatol, 22, 609, 10.1111/exd.12209

Megiorni, 2011, Genetic association of HLA-DQB1 and HLA-DRB1 polymorphisms with alopecia areata in the Italian population, Br J Dermatol, 165, 823, 10.1111/j.1365-2133.2011.10466.x

Jagielska, 2012, Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance, J Invest Dermatol, 132, 2192, 10.1038/jid.2012.129

Forstbauer, 2012, Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata, Eur J Hum Genet, 20, 326, 10.1038/ejhg.2011.185

Conteduca, 2014, Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata, Clin Exp Med, 14, 91, 10.1007/s10238-012-0224-3

Kalkan, 2013, The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population, Gene, 527, 565, 10.1016/j.gene.2013.05.086

Perricone, 2013, Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: Unveiling the pathogenic, clinical and diagnostic aspects, J Autoimmun, 47, 1, 10.1016/j.jaut.2013.10.004

Pillai, 2013, Rethinking mechanisms of autoimmune pathogenesis, J Autoimmun, 45, 97, 10.1016/j.jaut.2013.05.003

Selmi, 2012, Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop, J Autoimmun, 39, 272, 10.1016/j.jaut.2012.05.007

Costenbader, 2012, Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?, Autoimmun Rev, 11, 604, 10.1016/j.autrev.2011.10.022

Ito, 2005, Human hair follicles display a functional equivalent of the hypothalamicpituitaryadrenal axis and synthesize cortisol, FASEB J, 19, 1332, 10.1096/fj.04-1968fje

Arck, 2003, Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways, Am J Pathol, 162, 803, 10.1016/S0002-9440(10)63877-1

Katsarou-Katsari, 2001, Alopecia areata and affected skin CRH receptor upregulation induced by acute emotional stress, Dermatology, 203, 157, 10.1159/000051732

Kim, 2006, Immunoreactivity of corticotropin-releasing hormone, adrenocorticotropic hormone and alpha-melanocyte-stimulating hormone in alopecia areata, Exp Dermatol, 15, 515, 10.1111/j.1600-0625.2006.00003.x

Harbuz, 2006, Stress in autoimmune disease models, Ann N Y Acad Sci, 1069, 51, 10.1196/annals.1351.005

Skinner, 1995, Alopecia areata and presence of cytomegalovirus DNA, JAMA, 273, 1419, 10.1001/jama.1995.03520420031025

Garcia-Hernandez, 1998, No evidence of cytomegalovirus DNA in alopecia areata, J Invest Dermatol, 110, 185, 10.1046/j.1523-1747.1998.00115.x

Gamal, 2014, Alopecia universalis after discontinuation of pegylated interferon and ribavirin combination therapy for hepatitis C: a case report, Ann Hepatol, 13, 293, 10.1016/S1665-2681(19)30894-4

Geier, 2005, A casecontrol study of serious autoimmune adverse events following hepatitis B immunization, Autoimmunity, 38, 295, 10.1080/08916930500144484

Ito, 2012, Advances in the management of alopecia areata, J Dermatol, 39, 11, 10.1111/j.1346-8138.2011.01476.x

Rodriguez, 2008, Onset of alopecia areata after EpsteinBarr virus infectious mononucleosis, J Am Acad Dermatol, 59, 137, 10.1016/j.jaad.2008.02.005

Shellow, 1992, Profile of alopecia areata: a questionnaire analysis of patient and family, Int J Dermatol, 31, 186, 10.1111/j.1365-4362.1992.tb03932.x

Fenoglio, 2012, Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases, Autoimmun Rev, 12, 300, 10.1016/j.autrev.2012.05.004

Gianchecchi, 2013, Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity, Autoimmun Rev, 12, 1091, 10.1016/j.autrev.2013.05.003

Romo-Tena, 2013, CTLA-4 and autoimmunity: new insights into the dual regulator of tolerance, Autoimmun Rev, 12, 1171, 10.1016/j.autrev.2013.07.002

Chen, 2013, Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis, Hepatology, 57, 1498, 10.1002/hep.26157

Kawata, 2013, Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis, PLoS One, 8, e74225, 10.1371/journal.pone.0074225

Lleo, 2014, Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells, Hepatology, 60, 1314, 10.1002/hep.27230

Tsuda, 2013, Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFbeta receptor type II mice, Hepatology, 57, 806, 10.1002/hep.25829

Wang, 2013, Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex, J Immunol, 191, 2126, 10.4049/jimmunol.1301092

Wang, 2014, Animal models of primary biliary cirrhosis, Semin Liver Dis, 34, 285, 10.1055/s-0034-1383728

Yang, 2012, Epitope-specific anti-nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine-dependent, Clin Exp Immunol, 168, 261, 10.1111/j.1365-2249.2012.04577.x

Yang, 2014, IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy, Hepatology, 59, 1944, 10.1002/hep.26979

Bowlus, 2014, The diagnosis of primary biliary cirrhosis, Autoimmun Rev, 13, 441, 10.1016/j.autrev.2014.01.041

Zhang, 2014, Ongoing activation of autoantigen-specific b cells in primary biliary cirrhosis, Hepatology, 10.1002/hep.27313

Ando, 2013, Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-beta receptor type II mouse, J Autoimmun, 41, 111, 10.1016/j.jaut.2012.12.013

Chang, 2014, Innate immunity drives xenobiotic-induced murine autoimmune cholangitis, Clin Exp Immunol, 177, 373, 10.1111/cei.12298

Leung, 2013, Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA, J Autoimmun, 41, 79, 10.1016/j.jaut.2012.12.007

Lleo, 2012, Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis, Hepatology, 55, 153, 10.1002/hep.24630

Lleo, 2013, Y chromosome loss in male patients with primary biliary cirrhosis, J Autoimmun, 41, 87, 10.1016/j.jaut.2012.12.008

Rong, 2013, Human intrahepatic biliary epithelial cells engulf blebs from their apoptotic peers, Clin Exp Immunol, 172, 95, 10.1111/cei.12046

Wang, 2013, Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis, J Autoimmun, 41, 140, 10.1016/j.jaut.2012.10.004

Dhirapong, 2013, Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis, Hepatology, 57, 708, 10.1002/hep.26067

Tanaka, 2013, Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis, Clin Exp Immunol, 174, 364, 10.1111/cei.12193

Tsuda, 2012, Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid, Hepatology, 55, 512, 10.1002/hep.24748

Tanaka, 2014, Successful immunotherapy of autoimmune cholangitis by adoptive transfer of Foxp3 regulatory T cells, Clin Exp Immunol, 178, 253, 10.1111/cei.12415

Sipetic, 2002, Family history and risk of type 1 diabetes mellitus, Acta Diabetol, 39, 111, 10.1007/s005920200028

Seetharam, 2013, Alopecia areata: an update, Indian J Dermatol Venereol Leprol, 79, 563, 10.4103/0378-6323.116725

Avidan, 2014, Genetic basis of myasthenia gravis—a comprehensive review, J Autoimmun, 52C, 146, 10.1016/j.jaut.2013.12.001

Hasham, 2013, Genetic analysis of interferon induced thyroiditis (IIT): evidence for a key role for MHC and apoptosis related genes and pathways, J Autoimmun, 44, 61, 10.1016/j.jaut.2013.04.002

Carter, 1976, Alopecia areata and Down syndrome, Arch Dermatol, 112, 1397, 10.1001/archderm.1976.01630340015003

Paus, 1993, Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?, Yale J Biol Med, 66, 541

Gilhar, 2001, Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice, J Invest Dermatol, 117, 1357, 10.1046/j.0022-202x.2001.01583.x

Alzolibani, 2012, Epidemiologic and genetic characteristics of alopecia areata (part 2), Acta Dermatovenerol Alp Panonica Adriat, 21, 15

Todes-Taylor, 1984, T cell subpopulations in alopecia areata, J Am Acad Dermatol, 11, 216, 10.1016/S0190-9622(84)70152-6

Ito, 2008, Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack, J Invest Dermatol, 128, 1196, 10.1038/sj.jid.5701183

Arca, 2004, Interferon-gamma in alopecia areata, Eur J Dermatol, 14, 33

Antonelli, 2014, Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases, Autoimmun Rev, 13, 272, 10.1016/j.autrev.2013.10.010

Cordiglieri, 2014, Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity, J Autoimmun, 52, 74, 10.1016/j.jaut.2013.12.013

Cufi, 2014, Central role of interferon-beta in thymic events leading to myasthenia gravis, J Autoimmun, 52, 44, 10.1016/j.jaut.2013.12.016

Lee, 2013, The interaction between CXCL10 and cytokines in chronic inflammatory arthritis, Autoimmun Rev, 12, 554, 10.1016/j.autrev.2012.10.001

Benoit, 2003, Selective expression of chemokine monokine induced by interferon-gamma in alopecia areata, J Invest Dermatol, 121, 933, 10.1046/j.1523-1747.2003.12524.x

Subramanya, 2010, Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures, Genomics, 96, 146, 10.1016/j.ygeno.2010.05.002

Ito, 2013, CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase, J Dermatol Sci, 69, 140, 10.1016/j.jdermsci.2012.12.003

Hudspeth, 2013, The role of natural killer cells in autoimmune liver disease: a comprehensive review, J Autoimmun, 46, 55, 10.1016/j.jaut.2013.07.003

Rival, 2014, The unique neonatal NK cells: a critical component required for neonatal autoimmune disease induction by maternal autoantibody, Front Immunol, 5, 242, 10.3389/fimmu.2014.00242

Tian, 2012, Regulatory NK cells in autoimmune disease, J Autoimmun, 39, 206, 10.1016/j.jaut.2012.05.006

Bauer, 1999, Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA, Science, 285, 727, 10.1126/science.285.5428.727

Sundberg, 1994, Alopecia areata in aging C3H/HeJ mice, J Invest Dermatol, 102, 847, 10.1111/1523-1747.ep12382416

Xing, 2014, Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition, Nat Med, 20, 1043, 10.1038/nm.3645

Wasserman, 2007, Alopecia areata, Int J Dermatol, 46, 121, 10.1111/j.1365-4632.2007.03193.x

Weise, 1996, Topical immunotherapy in alopecia areata: anamnestic and clinical criteria of prognostic significance, Dermatology, 192, 129, 10.1159/000246337

Invernizzi, 2014, New therapeutics in primary biliary cirrhosis: will there ever be light?, Liver Int, 34, 167, 10.1111/liv.12354

Berrih-Aknin, 2014, Myasthenia gravis: paradox versus paradigm in autoimmunity, J Autoimmun, 52, 1, 10.1016/j.jaut.2014.05.001

Cornec, 2014, Sjogren's syndrome: where do we stand, and where shall we go?, J Autoimmun, 51, 109, 10.1016/j.jaut.2014.02.006

Huang, 2014, Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells, J Autoimmun, 50, 123, 10.1016/j.jaut.2014.01.034

Kivity, 2014, Infection and autoimmunity in Sjogren's syndrome: a clinical study and comprehensive review, J Autoimmun, 51, 17, 10.1016/j.jaut.2014.02.008

Messenger, 2012, British Association of Dermatologists' guidelines for the management of alopecia areata 2012, Br J Dermatol, 166, 916, 10.1111/j.1365-2133.2012.10955.x

Delamere, 2008, Interventions for alopecia areata, Cochrane Database Syst Rev, Cd004413

McMichael, 2007, Alopecia in the United States: outpatient utilization and common prescribing patterns, J Am Acad Dermatol, 57, S49, 10.1016/j.jaad.2006.02.045

Sharma, 1996, Profile of alopecia areata in Northern India, Int J Dermatol, 35, 22, 10.1111/j.1365-4362.1996.tb01610.x

Safavi, 1995, Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989, Mayo Clin Proc, 70, 628, 10.4065/70.7.628

Al-Mutairi, 2011, Clinical profile and impact on quality of life: seven years experience with patients of alopecia areata, Indian J Dermatol Venereol Leprol, 77, 489, 10.4103/0378-6323.82411

Bhat, 2009, Trace element levels in alopecia areata, Indian J Dermatol Venereol Leprol, 75, 29, 10.4103/0378-6323.45216

Muller, 1963, Alopecia areata. An evaluation of 736 patients, Arch Dermatol, 88, 290, 10.1001/archderm.1963.01590210048007

Dhirapong, 2011, B cell depletion therapy exacerbates murine primary biliary cirrhosis, Hepatology, 53, 527, 10.1002/hep.24044

Safavi, 1992, Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey, Arch Dermatol, 128, 702, 10.1001/archderm.1992.01680150136027

Schwartz, 1997, Alopecia areata, Cutis, 59, 238

Tazi-Ahnini, 2000, Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region, Hum Genet, 106, 639

Price, 1991, Alopecia areata: clinical aspects, J Invest Dermatol, 96, 68s, 10.1111/1523-1747.ep12471869

Sawaya, 1992, Advances in alopecia areata and androgenetic alopecia, Adv Dermatol, 7, 211

Price, 1996, Heritable factors distinguish two types of alopecia areata, Dermatol Clin, 14, 679, 10.1016/S0733-8635(05)70394-6

Blaumeiser, 2006, Familial aggregation of alopecia areata, J Am Acad Dermatol, 54, 627, 10.1016/j.jaad.2005.12.007

Jackow, 1998, Alopecia areata and cytomegalovirus infection in twins: genes versus environment?, J Am Acad Dermatol, 38, 418, 10.1016/S0190-9622(98)70499-2

Cooper, 2009, Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases, J Autoimmun, 33, 197, 10.1016/j.jaut.2009.09.008

Price, 1999, Treatment of hair loss, N Engl J Med, 341, 964, 10.1056/NEJM199909233411307

McDonagh, 1996, The pathogenesis of alopecia areata, Dermatol Clin, 14, 661, 10.1016/S0733-8635(05)70392-2

Crowder, 2002, Alopecia areata in infants and newborns, Pediatr Dermatol, 19, 155, 10.1046/j.1525-1470.2002.00034.x

Norris, 2004, Alopecia areata: current state of knowledge, J Am Acad Dermatol, 51, S16, 10.1016/j.jaad.2004.01.013

Barahmani, 2002, Interleukin-1 receptor antagonist allele 2 and familial alopecia areata, J Invest Dermatol, 118, 335, 10.1046/j.0022-202x.2001.01676.x

Hordinsky, 2004, Autoimmunity: alopecia areata, J Investig Dermatol Symp Proc, 9, 73, 10.1111/j.1087-0024.2004.00835.x

Xiao, 2005, Association of HLA-DQA1 and DQB1 alleles with alolpecia areata in Chinese Hans, Arch Dermatol Res, 297, 201, 10.1007/s00403-005-0608-2

Morling, 1991, DNA polymorphism of HLA class II genes in alopecia areata, Dis Markers, 9, 35

Kianto, 1977, HLA-B12 in alopecia areata, Arch Dermatol, 113, 1716, 10.1001/archderm.1977.01640120084017

Hacham-Zadeh, 1981, HLA and alopecia areata in Jerusalem, Tissue Antigens, 18, 71, 10.1111/j.1399-0039.1981.tb01366.x

Averbakh, 1986, HLA antigens of patients with alopecia areata, Vestn Dermatol Venerol, 24

Kavak, 2000, HLA in alopecia areata, Int J Dermatol, 39, 589, 10.1046/j.1365-4362.2000.00921.x

Colombe, 1999, The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis, J Investig Dermatol Symp Proc, 4, 216, 10.1038/sj.jidsp.5640214